{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:08:01Z","timestamp":1790024881577,"version":"4.0.1"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2020,3,13]]},"abstract":"<jats:sec>\n            <jats:title>Rationale:<\/jats:title>\n            <jats:p>Heart failure (HF) following heart damage leads to a decreased blood flow due to a reduced pump efficiency of the heart muscle. A consequence can be insufficient oxygen supply to the organism including the brain. While HF clearly shows neurological symptoms, such as fatigue, nausea, and dizziness, the implications for brain structure are not well understood. Few studies show regional gray matter decrease related to HF; however, the underlying mechanisms leading to the observed brain changes remain unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>To study the relationship between impaired heart function, hampered blood circulation, and structural brain change in a case-control study.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>Within a group of 80 patients of the Leipzig Heart Center, we investigated a potential correlation between HF biomarkers and the brain\u2019s gray matter density (GMD) obtained by magnetic resonance imaging. We observed a significant positive correlation between cardiac ejection fraction and GMD across the whole frontal and parietal medial cortex reflecting the consequence of HF onto the brain\u2019s gray matter. Moreover, we also obtained a relationship between GMD and the NT-proBNP (N-terminal prohormone of brain natriuretic peptide)\u2014a biomarker that is used for screening, diagnosis, and prognosis of HF. Here, we found a significant negative correlation between NT-proBNP and GMD in the medial and posterior cingulate cortex but also in precuneus and hippocampus, which are key regions implicated in structural brain changes in dementia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>We obtained significant correlations between brain structure and markers of heart failure including ejection fraction and NT-proBNP. A diminished GMD was found with decreased ejection fraction and increased NT-proBNP in wide brain regions including the whole frontomedian cortex as well as hippocampus and precuneus. Our observations might reflect structural brain damage in areas that are related to cognition; however, whether these structural changes facilitate the development of cognitive alterations has to be proven by further longitudinal studies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circresaha.119.315813","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T10:00:14Z","timestamp":1579773614000},"page":"750-764","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":95,"title":["Brain Damage With Heart Failure"],"prefix":"10.1161","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9613-0552","authenticated-orcid":false,"given":"Karsten","family":"Mueller","sequence":"first","affiliation":[{"name":"From the Max Planck Institute for Human Cognitive and Brain Sciences, Germany (K.M., F.T., S.F., T.B., H.E.M., K.I., A.V., M.L.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Thiel","sequence":"additional","affiliation":[{"name":"From the Max Planck Institute for Human Cognitive and Brain Sciences, Germany (K.M., F.T., S.F., T.B., H.E.M., K.I., A.V., M.L.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Beutner","sequence":"additional","affiliation":[{"name":"Leipzig Heart Center, Germany (F.B., A.T., G.S.)"},{"name":"Leipzig Research Centre for Civilization Diseases, Germany (F.B., A.T., J.T., A.V., M.L.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Teren","sequence":"additional","affiliation":[{"name":"Leipzig Heart Center, Germany (F.B., A.T., G.S.)"},{"name":"Leipzig Research Centre for Civilization Diseases, Germany (F.B., A.T., J.T., A.V., M.L.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Frisch","sequence":"additional","affiliation":[{"name":"From the Max Planck Institute for Human Cognitive and Brain Sciences, Germany (K.M., F.T., S.F., T.B., H.E.M., K.I., A.V., M.L.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Ballarini","sequence":"additional","affiliation":[{"name":"From the Max Planck Institute for Human Cognitive and Brain Sciences, Germany (K.M., F.T., S.F., T.B., H.E.M., K.I., A.V., M.L.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald E.","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"From the Max Planck Institute for Human Cognitive and Brain Sciences, Germany (K.M., F.T., S.F., T.B., H.E.M., K.I., A.V., M.L.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Ihle","sequence":"additional","affiliation":[{"name":"From the Max Planck Institute for Human Cognitive and Brain Sciences, Germany (K.M., F.T., S.F., T.B., H.E.M., K.I., A.V., M.L.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Thiery","sequence":"additional","affiliation":[{"name":"Leipzig Heart Center, Germany (F.B., A.T., G.S.)"},{"name":"Leipzig Research Centre for Civilization Diseases, Germany (F.B., A.T., J.T., A.V., M.L.S.)"},{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Germany (J.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Schuler","sequence":"additional","affiliation":[{"name":"Leipzig Heart Center, Germany (F.B., A.T., G.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"Villringer","sequence":"additional","affiliation":[{"name":"From the Max Planck Institute for Human Cognitive and Brain Sciences, Germany (K.M., F.T., S.F., T.B., H.E.M., K.I., A.V., 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