{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:04:35Z","timestamp":1790417075941,"version":"4.1.0"},"reference-count":67,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL136373"],"award-info":[{"award-number":["R01HL136373"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2020,10,23]]},"abstract":"<jats:sec>\n            <jats:title>Rationale:<\/jats:title>\n            <jats:p>Prospective cohort studies question the value of HDL-C (high-density lipoprotein cholesterol) for stroke risk prediction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>Investigate the relationship between long-term functional recovery and HDL proteome and function.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>\n              Changes in HDL protein composition and function (cholesterol efflux capacity) in patients after acute ischemic stroke at 2 time points (24 hours, 35 patients; 96 hours, 20 patients) and in 35 control subjects were measured. The recovery from stroke was assessed by 3 months, the National Institutes of Health Stroke Scale and modified Rankin scale scores. When compared with control subject after adjustments for sex and HDL-C levels, 12 proteins some of which participate in acute phase response and platelet activation (APMAP [adipocyte plasma membrane-associated protein], GPLD1 [phosphate inositol-glycan specific phospholipase D], APOE [apolipoprotein E], IHH [Indian hedgehog protein], ITIH4 [inter-alpha-trypsin inhibitor chain H4], SAA2 [serum amyloid A2], APOA4 [apolipoprotein A-IV], CLU [clusterin], ANTRX2 [anthrax toxin receptor 2], PON1 [serum paraoxonase\/arylesterase], SERPINA1 [alpha-1-antitrypsin], and APOF [apolipoprotein F]) were significantly (adjusted\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) altered in stroke HDL at 96 hours. The first 8 of these proteins were also significantly altered at 24 hours. Consistent with inflammatory remodeling, cholesterol efflux capacity was reduced by 32% (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) at both time points. Baseline stroke severity adjusted regression model showed that changes within 96-hour poststroke in APOF, APOL1, APMAP, APOC4 (apolipoprotein C4), APOM (apolipoprotein M), PCYOX1 (prenylcysteine oxidase 1), PON1, and APOE correlate with stroke recovery scores (\n              <jats:italic>R<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =0.38\u20130.73, adjusted\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). APOF (\n              <jats:italic>R<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =0.73) and APOL1 (\n              <jats:italic>R<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =0.60) continued to significantly correlate with recovery scores after accounting for tPA (tissue-type plasminogen activator) treatment.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Changes in HDL proteins during early acute phase of stroke associate with recovery. Monitoring HDL proteins may provide clinical biomarkers that inform on stroke recuperation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circresaha.120.316526","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T09:00:19Z","timestamp":1598432419000},"page":"1274-1287","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["High-Density Lipoprotein Carries Markers That Track With Recovery From Stroke"],"prefix":"10.1161","volume":"127","author":[{"given":"Deanna L.","family":"Plubell","sequence":"first","affiliation":[{"name":"Knight Cardiovascular Institute, Department of Medicine (D.L.P., A.M.F., S.R., P.B., J.M., N.J.A., S.F., N.P.), Oregon Health &amp; Science University, Portland, OR."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex M.","family":"Fenton","sequence":"additional","affiliation":[{"name":"Knight Cardiovascular Institute, Department of Medicine (D.L.P., A.M.F., S.R., P.B., J.M., N.J.A., S.F., N.P.), Oregon Health &amp; 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Science University, Portland, OR."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8824-4410","authenticated-orcid":true,"given":"Neil A.","family":"Zakai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Larner College of Medicine, University of Vermont, Burlington (N.A.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Department of Neurology (W.M.C., J.F.Q.), Oregon Health &amp; Science University, Portland, OR."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3527-2757","authenticated-orcid":true,"given":"Jessica","family":"Minnier","sequence":"additional","affiliation":[{"name":"School of Public Health (J.M.), Oregon Health &amp; Science University, Portland, OR."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil J.","family":"Alkayed","sequence":"additional","affiliation":[{"name":"Knight Cardiovascular Institute, Department of Medicine (D.L.P., A.M.F., S.R., P.B., J.M., N.J.A., S.F., N.P.), Oregon Health &amp; 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