{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:06:43Z","timestamp":1792098403834,"version":"4.4.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","funder":[{"name":"National Key R&D program of China","award":["2016YFF0101504"],"award-info":[{"award-number":["2016YFF0101504"]}]},{"name":"National Key R&D program of China","award":["2020YFC0845500"],"award-info":[{"award-number":["2020YFC0845500"]}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["81630011; 81970364;81970070;81970011;81870171; 81700356"],"award-info":[{"award-number":["81630011; 81970364;81970070;81970011;81870171; 81700356"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Major Research Plan of the National Natural Science Foundation of China","award":["91639304"],"award-info":[{"award-number":["91639304"]}]},{"name":"Hubei Science and Technology Support Project","award":["2019BFC582; 2018BEC473; 2017BEC001"],"award-info":[{"award-number":["2019BFC582; 2018BEC473; 2017BEC001"]}]},{"name":"Medical flight plan of Wuhan University"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2020,6,5]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale:<\/jats:title>\n                    <jats:p>Use of ACEIs (angiotensin-converting enzyme inhibitors) and ARBs (angiotensin II receptor blockers) is a major concern for clinicians treating coronavirus disease 2019 (COVID-19) in patients with hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the association between in-hospital use of ACEI\/ARB and all-cause mortality in patients with hypertension and hospitalized due to COVID-19.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      This retrospective, multi-center study included 1128 adult patients with hypertension diagnosed with COVID-19, including 188 taking ACEI\/ARB (ACEI\/ARB group; median age 64 [interquartile range, 55\u201368] years; 53.2% men) and 940 without using ACEI\/ARB (non-ACEI\/ARB group; median age 64 [interquartile range 57\u201369]; 53.5% men), who were admitted to 9 hospitals in Hubei Province, China from December 31, 2019 to February 20, 2020. In mixed-effect Cox model treating site as a random effect, after adjusting for age, gender, comorbidities, and in-hospital medications, the detected risk for all-cause mortality was lower in the ACEI\/ARB group versus the non-ACEI\/ARB group (adjusted hazard ratio, 0.42 [95% CI, 0.19\u20130.92];\n                      <jats:italic>P<\/jats:italic>\n                      =0.03). In a propensity score-matched analysis followed by adjusting imbalanced variables in mixed-effect Cox model, the results consistently demonstrated lower risk of COVID-19 mortality in patients who received ACEI\/ARB versus those who did not receive ACEI\/ARB (adjusted hazard ratio, 0.37 [95% CI, 0.15\u20130.89];\n                      <jats:italic>P<\/jats:italic>\n                      =0.03). Further subgroup propensity score-matched analysis indicated that, compared with use of other antihypertensive drugs, ACEI\/ARB was also associated with decreased mortality (adjusted hazard ratio, 0.30 [95% CI, 0.12\u20130.70];\n                      <jats:italic>P<\/jats:italic>\n                      =0.01) in patients with COVID-19 and coexisting hypertension.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Among hospitalized patients with COVID-19 and coexisting hypertension, inpatient use of ACEI\/ARB was associated with lower risk of all-cause mortality compared with ACEI\/ARB nonusers. While study interpretation needs to consider the potential for residual confounders, it is unlikely that in-hospital use of ACEI\/ARB was associated with an increased mortality risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circresaha.120.317134","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T15:19:29Z","timestamp":1587136769000},"page":"1671-1681","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":798,"title":["Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19"],"prefix":"10.1161","volume":"126","author":[{"given":"Peng","family":"Zhang","sequence":"first","affiliation":[{"name":"From the Cardiology (P.Z., L.Z., J.-J.Q., J. Xie, Y.-M.L., Y.-C.Z., X. Huang, M.-M.C., X.C., Z.-G.S., X.-J.Z., H.L.), Renmin Hospital of Wuhan University"},{"name":"Medical Science Research Center (P.Z., Y.-X.J., H.L.), Zhongnan Hospital of Wuhan University"},{"name":"Institute of Model Animal of Wuhan University (P.Z., L.Z., F.L., J.-J.Q., Y.-M.L., Y.-C.Z., X. Huang, L. Lin, M.X., M.-M.C., X.C., Y.-X.J., J. Chen, Z.-G.S., X.-J.Z., H.L.)"},{"name":"Basic Medical School, Wuhan University (P.Z., L. Lin, H.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Zhu","sequence":"additional","affiliation":[{"name":"From the Cardiology (P.Z., L.Z., J.-J.Q., J. Xie, Y.-M.L., Y.-C.Z., X. Huang, M.-M.C., X.C., Z.-G.S., X.-J.Z., H.L.), Renmin Hospital of Wuhan University"},{"name":"Institute of Model Animal of Wuhan University (P.Z., L.Z., F.L., J.-J.Q., Y.-M.L., Y.-C.Z., X. Huang, L. Lin, M.X., M.-M.C., X.C., Y.-X.J., J. 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