{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T01:51:00Z","timestamp":1793670660351,"version":"4.5.1"},"reference-count":230,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2021,6,11]]},"abstract":"<jats:p>The association between inflammation, infection, and venous thrombosis has long been recognized; yet, only in the last decades have we begun to understand the mechanisms through which the immune and coagulation systems interact and reciprocally regulate one another. These interconnected networks mount an effective response to injury and pathogen invasion, but if unregulated can result in pathological thrombosis and organ damage. Neutrophils, monocytes, and platelets interact with each other and the endothelium in host defense and also play critical roles in the formation of venous thromboembolism. This knowledge has advanced our understanding of both human physiology and pathophysiology, as well as identified mechanisms of anticoagulant resistance and novel therapeutic targets for the prevention and treatment of thrombosis. In this review, we discuss the contributions of inflammation and infection to venous thromboembolism.<\/jats:p>","DOI":"10.1161\/circresaha.121.318225","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T14:00:32Z","timestamp":1623333632000},"page":"2017-2036","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":299,"title":["Inflammation, Infection and Venous Thromboembolism"],"prefix":"10.1161","volume":"128","author":[{"given":"Meaghan E.","family":"Colling","sequence":"first","affiliation":[{"name":"Division of Intramural Research (M.E.C.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD."},{"name":"Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Austria (M.E.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1701-4041","authenticated-orcid":true,"given":"Benjamin E.","family":"Tourdot","sequence":"additional","affiliation":[{"name":"Experimental Hematology and Cancer Biology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH (B.E.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5660-5194","authenticated-orcid":true,"given":"Yogendra","family":"Kanthi","sequence":"additional","affiliation":[{"name":"Laboratory of Vascular Thrombosis and Inflammation, Intramural Research Program (Y.K.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304488"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.016784"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.6"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X18770529"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2021.101661"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60229"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.306853"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-012110-142305"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3345"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0952-7915(01)00302-8"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1101245"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201031109"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.185785"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-014-0425-1"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.023301"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.110.2.139"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1998.275.1.L47"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-015-0124-z"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311102"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-012419-032847"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI79514"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.02.06.db05-1103"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783x-14-12-526"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-011-0284-6"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V73.5.1109.1109"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.95.1.355"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14322"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000209501.56852.6c"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311185"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-142422"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/1076029611405032"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304457"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.04.045"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611770"},{"key":"e_1_3_5_36_2","unstructured":"Lowenstein CJ. Crizanlizumab for treating COVID-19 vasculopathy."},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-04-0323"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12279"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-287623"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-276311"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314690"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-315473"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0519-3"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30216-7"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314860"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.310367"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1996.0205"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1101\/2021.01.18.21250041"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00085"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402800101"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03204.x"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2033369"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.228999"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000255691.76142.4a"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1434429100"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-209981"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124791"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20112322"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2002.6552"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.93897"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-05-850859"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-330878"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001758"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.12.2641.2641"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.312407"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.04.003"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092239"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0004-8"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.5.1860.h81702001860_1860_1868"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-457671"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39938"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2012.719952"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI137866"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04544.x"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3MA0916-411R"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09801-x"},{"key":"e_1_3_5_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1959"},{"key":"e_1_3_5_79_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-412197"},{"key":"e_1_3_5_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09160-7"},{"key":"e_1_3_5_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2005.11.003"},{"key":"e_1_3_5_82_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-020-02324-z"},{"key":"e_1_3_5_83_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.138999"},{"key":"e_1_3_5_84_2","article-title":"Understanding ChAdOx1 nCov-19 vaccine-induced immune thrombotic thrombocytopenia (VITT).","author":"Greinacher ASK","year":"2021","unstructured":"Greinacher, ASK, Wesche, J, Handtke, S, Palankar, R, Aurich, K, Lalk, M, Methling, K, V\u00f6lker, U, Hentschker, C, Michalik, S, et al. Understanding ChAdOx1 nCov-19 vaccine-induced immune thrombotic thrombocytopenia (VITT). Preprint Available Res Square. 2021.","journal-title":"Preprint Available Res Square"},{"key":"e_1_3_5_85_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay5691"},{"key":"e_1_3_5_86_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007008"},{"key":"e_1_3_5_87_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1301059110"},{"key":"e_1_3_5_88_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.242859"},{"key":"e_1_3_5_89_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405883200"},{"key":"e_1_3_5_90_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200606027"},{"key":"e_1_3_5_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1565"},{"key":"e_1_3_5_92_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abd3876"},{"key":"e_1_3_5_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06263-5"},{"key":"e_1_3_5_94_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1909546117"},{"key":"e_1_3_5_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33385-z"},{"key":"e_1_3_5_96_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-020520-111016"},{"key":"e_1_3_5_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4027"},{"key":"e_1_3_5_98_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000675"},{"key":"e_1_3_5_99_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-587709"},{"key":"e_1_3_5_100_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160530"},{"key":"e_1_3_5_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.01.019"},{"key":"e_1_3_5_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.01.019"},{"key":"e_1_3_5_103_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305259"},{"key":"e_1_3_5_104_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.53353"},{"key":"e_1_3_5_105_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14835"},{"key":"e_1_3_5_106_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008345"},{"key":"e_1_3_5_107_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005743107"},{"key":"e_1_3_5_108_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-339572"},{"key":"e_1_3_5_109_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-06-722298"},{"key":"e_1_3_5_110_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.41460"},{"key":"e_1_3_5_111_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-08-0669"},{"key":"e_1_3_5_112_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-741298"},{"key":"e_1_3_5_113_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v98.5.1440"},{"key":"e_1_3_5_114_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21062080"},{"key":"e_1_3_5_115_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04422.x"},{"key":"e_1_3_5_116_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-332676"},{"key":"e_1_3_5_117_2","doi-asserted-by":"publisher","DOI":"10.1101\/2021.03.31.21254692"},{"key":"e_1_3_5_118_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909927107"},{"key":"e_1_3_5_119_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208356"},{"key":"e_1_3_5_120_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15367"},{"key":"e_1_3_5_121_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100450"},{"key":"e_1_3_5_122_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-017-2751-4"},{"key":"e_1_3_5_123_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13464"},{"key":"e_1_3_5_124_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115828"},{"key":"e_1_3_5_125_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.91356"},{"key":"e_1_3_5_126_2","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3COVCRA0720-359R"},{"key":"e_1_3_5_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.002"},{"key":"e_1_3_5_128_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389201020666190111164145"},{"key":"e_1_3_5_129_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0381-3"},{"key":"e_1_3_5_130_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.140971"},{"key":"e_1_3_5_131_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa789"},{"key":"e_1_3_5_132_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309846"},{"key":"e_1_3_5_133_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-3400959"},{"key":"e_1_3_5_134_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.308925"},{"key":"e_1_3_5_135_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-460493"},{"key":"e_1_3_5_136_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.136333"},{"key":"e_1_3_5_137_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-019-0194-8"},{"key":"e_1_3_5_138_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00492a016"},{"key":"e_1_3_5_139_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007252"},{"key":"e_1_3_5_140_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.315547"},{"key":"e_1_3_5_141_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI141374"},{"key":"e_1_3_5_142_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124804"},{"key":"e_1_3_5_143_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa8064"},{"key":"e_1_3_5_144_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.11.005"},{"key":"e_1_3_5_145_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.58"},{"key":"e_1_3_5_146_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10555"},{"key":"e_1_3_5_147_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200105058"},{"key":"e_1_3_5_148_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018021709"},{"key":"e_1_3_5_149_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1620458114"},{"key":"e_1_3_5_150_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01322"},{"key":"e_1_3_5_151_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007878"},{"key":"e_1_3_5_152_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2956"},{"key":"e_1_3_5_153_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0110-0"},{"key":"e_1_3_5_154_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310795"},{"key":"e_1_3_5_155_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-462432"},{"key":"e_1_3_5_156_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314645"},{"key":"e_1_3_5_157_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.314008"},{"key":"e_1_3_5_158_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01687"},{"key":"e_1_3_5_159_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007214"},{"key":"e_1_3_5_160_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114238"},{"key":"e_1_3_5_161_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1712746"},{"key":"e_1_3_5_162_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-02-0162"},{"key":"e_1_3_5_163_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09607-x"},{"key":"e_1_3_5_164_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-10-672964"},{"key":"e_1_3_5_165_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000966"},{"key":"e_1_3_5_166_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-742999"},{"key":"e_1_3_5_167_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314180"},{"key":"e_1_3_5_168_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2012.719946"},{"key":"e_1_3_5_169_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-04-710632"},{"key":"e_1_3_5_170_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064631"},{"key":"e_1_3_5_171_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3A0415-161R"},{"key":"e_1_3_5_172_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-266791"},{"key":"e_1_3_5_173_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17639-x"},{"key":"e_1_3_5_174_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.11.001"},{"key":"e_1_3_5_175_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-306605"},{"key":"e_1_3_5_176_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507195103"},{"key":"e_1_3_5_177_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00076"},{"key":"e_1_3_5_178_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-515726"},{"key":"e_1_3_5_179_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002355"},{"key":"e_1_3_5_180_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008762"},{"key":"e_1_3_5_181_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-301424"},{"key":"e_1_3_5_182_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-342857"},{"key":"e_1_3_5_183_2","article-title":"SARS-CoV-2 receptor binding domain-specific antibodies activate platelets with features resembling the pathogenic antibodies in heparin-induced thrombocytopenia.","author":"Zhu WZY","year":"2021","unstructured":"Zhu, WZY, Mei, Y, Wei, J, Zhang, Y, Topchyan, P, Nguyen, C, Janecke, R, Kreuziger, LB, White, GC, Hari, P, et al. SARS-CoV-2 receptor binding domain-specific antibodies activate platelets with features resembling the pathogenic antibodies in heparin-induced thrombocytopenia. Preprint available at Research Square. 2021.","journal-title":"Preprint available at Research Square"},{"key":"e_1_3_5_184_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2104840"},{"key":"e_1_3_5_185_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2104882"},{"key":"e_1_3_5_186_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00131"},{"key":"e_1_3_5_187_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-11-749879"},{"key":"e_1_3_5_188_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.9.4786"},{"key":"e_1_3_5_189_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-5890(99)00048-6"},{"key":"e_1_3_5_190_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00067"},{"key":"e_1_3_5_191_2","doi-asserted-by":"publisher","DOI":"10.1080\/09537100802238494"},{"key":"e_1_3_5_192_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2797"},{"key":"e_1_3_5_193_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01212"},{"key":"e_1_3_5_194_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2029073"},{"key":"e_1_3_5_195_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2006348117"},{"key":"e_1_3_5_196_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2029834"},{"key":"e_1_3_5_197_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2015.251314"},{"key":"e_1_3_5_198_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.200964"},{"key":"e_1_3_5_199_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.315187"},{"key":"e_1_3_5_200_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.06.047"},{"key":"e_1_3_5_201_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309301"},{"key":"e_1_3_5_202_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051650"},{"key":"e_1_3_5_203_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4673"},{"key":"e_1_3_5_204_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan8292"},{"key":"e_1_3_5_205_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-017-0035-6"},{"key":"e_1_3_5_206_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12040934"},{"key":"e_1_3_5_207_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050664"},{"key":"e_1_3_5_208_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.02.008"},{"key":"e_1_3_5_209_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.140.3.797"},{"key":"e_1_3_5_210_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02011"},{"key":"e_1_3_5_211_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-499111"},{"key":"e_1_3_5_212_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.308595"},{"key":"e_1_3_5_213_2","doi-asserted-by":"publisher","DOI":"10.1086\/509899"},{"key":"e_1_3_5_214_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191865"},{"key":"e_1_3_5_215_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aao1617"},{"key":"e_1_3_5_216_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01731"},{"key":"e_1_3_5_217_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109761"},{"key":"e_1_3_5_218_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/141806"},{"key":"e_1_3_5_219_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.23026"},{"key":"e_1_3_5_220_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-334672"},{"key":"e_1_3_5_221_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008123"},{"key":"e_1_3_5_222_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.592121"},{"key":"e_1_3_5_223_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2636"},{"key":"e_1_3_5_224_2","doi-asserted-by":"publisher","DOI":"10.1101\/2020.12.28.20248807"},{"key":"e_1_3_5_225_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(85)90228-2"},{"key":"e_1_3_5_226_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.323287"},{"key":"e_1_3_5_227_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00310-15"},{"key":"e_1_3_5_228_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2018874859"},{"key":"e_1_3_5_229_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-04-639849"},{"key":"e_1_3_5_230_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81390-2"},{"key":"e_1_3_5_231_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab078"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.121.318225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:56:37Z","timestamp":1715561797000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.121.318225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,11]]},"references-count":230,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,6,11]]}},"alternative-id":["10.1161\/CIRCRESAHA.121.318225"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.121.318225","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,11]]},"assertion":[{"value":"2021-06-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}