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In this review, we provide an overview of the primary types of genetic analyses performed for peripheral artery disease, including heritability and linkage studies, and more recently biobank-based genome-wide association studies. Looking forward, we highlight areas of future study including efforts to identify causal peripheral artery disease genes, rare variant and structural variant analyses using whole-exome and whole-genome sequencing data, and the need to include individuals of diverse genetic ancestries.<\/jats:p>","DOI":"10.1161\/circresaha.121.318327","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T18:00:32Z","timestamp":1623348032000},"page":"1805-1817","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["Genetic Determinants of Peripheral Artery Disease"],"prefix":"10.1161","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4636-5780","authenticated-orcid":true,"given":"Derek","family":"Klarin","sequence":"first","affiliation":[{"name":"Malcolm Randall VA Medical Center, Gainesville, FL (D.K.)."},{"name":"Division of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville (D.K.)."},{"name":"Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (D.K.)."},{"name":"Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (D.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7274-9318","authenticated-orcid":true,"given":"Philip S.","family":"Tsao","sequence":"additional","affiliation":[{"name":"VA Palo Alto Health Care System, CA (P.S.T.)."},{"name":"Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, CA (P.S.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8009-1632","authenticated-orcid":true,"given":"Scott M.","family":"Damrauer","sequence":"additional","affiliation":[{"name":"Corporal Michael J. 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