{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:03:22Z","timestamp":1787069002818,"version":"build-2736575974"},"reference-count":63,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2021,7,23]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale:<\/jats:title>\n                    <jats:p>\n                      Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare disease, manifested by syncope or sudden death in children or young adults under stress conditions. Mutations in the Ca\n                      <jats:sup>2+<\/jats:sup>\n                      release channel\/RyR2 (type 2 ryanodine receptor) gene account for about 60% of the identified mutations. Recently, we found and described a mutation in RyR2 N-terminal domain, RyR2\n                      <jats:sup>R420Q<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the arrhythmogenic mechanisms of this mutation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      Ventricular tachycardias under stress conditions were observed in both patients with catecholaminergic polymorphic ventricular tachycardia and knock-in mice. During action potential recording (by patch-clamp in knock-in mouse cardiomyocytes and by microelectrodes in mutant human induced pluripotent stem cell-derived cardiomyocytes), we observed an increased occurrence of delayed afterdepolarizations under isoproterenol stimulation, associated with increased Ca\n                      <jats:sup>2+<\/jats:sup>\n                      waves during confocal Ca\n                      <jats:sup>2+<\/jats:sup>\n                      recording in both mouse and human RyR2\n                      <jats:sup>R420Q<\/jats:sup>\n                      cardiomyocytes. In addition, Ca\n                      <jats:sup>2+<\/jats:sup>\n                      -induced Ca\n                      <jats:sup>2+<\/jats:sup>\n                      -release, as well as a rough indicator of fractional Ca\n                      <jats:sup>2+<\/jats:sup>\n                      release, were higher and Ca\n                      <jats:sup>2+<\/jats:sup>\n                      sparks longer in the RyR2\n                      <jats:sup>R420Q<\/jats:sup>\n                      -expressing cells. At the ultrastructural nanodomain level, we observed smaller RyR2 clusters and widened junctional sarcoplasmic reticulum measured by gated stimulated emission depletion super-resolution and electron microscopy, respectively. The increase in junctional sarcoplasmic reticulum width might be due to the impairment of RyR2\n                      <jats:sup>R420Q<\/jats:sup>\n                      binding to JPH2 (junctophilin-2), as there were less junctophilin-2 coimmunoprecipitated with RyR2\n                      <jats:sup>R420Q<\/jats:sup>\n                      . At the single current level, the RyR2\n                      <jats:sup>R420Q<\/jats:sup>\n                      channel dwells longer in the open state at low intracellular Ca\n                      <jats:sup>2+<\/jats:sup>\n                      ([Ca\n                      <jats:sup>2+<\/jats:sup>\n                      ]\n                      <jats:sub>i<\/jats:sub>\n                      ), but there is predominance of a subconductance state. The latter might be correlated with an enhanced interaction between the N terminus and the core solenoid, a RyR2 interdomain association that has not been previously implicated in the pathogenesis of arrhythmias and sudden cardiac death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      The RyR2\n                      <jats:sup>R420Q<\/jats:sup>\n                      catecholaminergic polymorphic ventricular tachycardia mutation modifies the interdomain interaction of the channel and weakens its association with JPH2. These defects may underlie both nanoscale disarrangement of the dyad and channel dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circresaha.121.319094","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T05:02:07Z","timestamp":1623387727000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":37,"title":["Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation"],"prefix":"10.1161","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2341-7090","authenticated-orcid":true,"given":"Liheng","family":"Yin","sequence":"first","affiliation":[{"name":"Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Universit\u00e9 Paris-Saclay 92296 Ch\u00e2tenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5170-118X","authenticated-orcid":true,"suffix":"Jr","given":"Alexandra","family":"Zahradnikova","sequence":"additional","affiliation":[{"name":"Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Universit\u00e9 Paris-Saclay 92296 Ch\u00e2tenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Rizzetto","sequence":"additional","affiliation":[{"name":"Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Universit\u00e9 Paris-Saclay 92296 Ch\u00e2tenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Boncompagni","sequence":"additional","affiliation":[{"name":"CAST, Department of Neuroscience, Imaging and Clinical Sciences (DNICS), Medicine and Ageing Sciences (DMSI), University Gabriele d\u2019Annunzio, Chieti, Italy (S.B., F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Rabesahala de Meritens","sequence":"additional","affiliation":[{"name":"Swansea University Medical School, Institute of Life Science, Swansea, SA2 8PP, UK (C.R.d.M., Y.Z., S.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0955-3595","authenticated-orcid":true,"given":"Yadan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Swansea University Medical School, Institute of Life Science, Swansea, SA2 8PP, UK (C.R.d.M., Y.Z., S.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5873-7000","authenticated-orcid":true,"given":"Pierre","family":"Joanne","sequence":"additional","affiliation":[{"name":"Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Universit\u00e9 Paris-Saclay 92296 Ch\u00e2tenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Marqu\u00e9s-Sul\u00e9","sequence":"additional","affiliation":[{"name":"Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Universit\u00e9 Paris-Saclay 92296 Ch\u00e2tenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.)."},{"name":"Physiotherapy, University of Valencia, Valencia, Spain (E.M.-S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5516-8877","authenticated-orcid":true,"given":"Yuriana","family":"Aguilar-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Physiology and Biophysics, Rush University Medical Center, Chicago, IL, USA (Y.A.-S., J.R.-F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8835-6631","authenticated-orcid":true,"given":"Miguel","family":"Fern\u00e1ndez-Tenorio","sequence":"additional","affiliation":[{"name":"Physiology, University of Bern, Bern, Switzerland (M.F.-T., E.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Villejoubert","sequence":"additional","affiliation":[{"name":"Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Universit\u00e9 Paris-Saclay 92296 Ch\u00e2tenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linwei","family":"Li","sequence":"additional","affiliation":[{"name":"Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Universit\u00e9 Paris-Saclay 92296 Ch\u00e2tenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Universit\u00e9 Paris-Saclay 92296 Ch\u00e2tenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Mateo","sequence":"additional","affiliation":[{"name":"Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Universit\u00e9 Paris-Saclay 92296 Ch\u00e2tenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Nicolas","sequence":"additional","affiliation":[{"name":"IPSIT, 92296 Ch\u00e2tenay-Malabry, France (V.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Gerbaud","sequence":"additional","affiliation":[{"name":"Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Universit\u00e9 Paris-Saclay 92296 Ch\u00e2tenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2852-8547","authenticated-orcid":true,"given":"F. Anthony","family":"Lai","sequence":"additional","affiliation":[{"name":"College of Medicine, Biomedical &amp; Pharmaceutical Research Unit, QU Health, &amp; Biomedical Research Centre, Qatar University, Doha, Qatar (F.A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Perrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3389-7574","authenticated-orcid":true,"given":"Julio L.","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Universit\u00e9 Paris-Saclay 92296 Ch\u00e2tenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.)."},{"name":"Institute of Cardiology, Havana, Cuba (J.L.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4670-4903","authenticated-orcid":true,"given":"Ernst","family":"Niggli","sequence":"additional","affiliation":[{"name":"Physiology, University of Bern, Bern, Switzerland (M.F.-T., E.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor H.","family":"Valdivia","sequence":"additional","affiliation":[{"name":"Medicine and Cardiovascular Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin (H.H.V., C.R.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-3088","authenticated-orcid":true,"given":"Carmen R.","family":"Valdivia","sequence":"additional","affiliation":[{"name":"Medicine and Cardiovascular Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin (H.H.V., C.R.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3389-7574","authenticated-orcid":true,"given":"Josefina","family":"Ramos-Franco","sequence":"additional","affiliation":[{"name":"Physiology and Biophysics, Rush University Medical Center, Chicago, IL, USA (Y.A.-S., J.R.-F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3608-4210","authenticated-orcid":true,"given":"Esther","family":"Zorio","sequence":"additional","affiliation":[{"name":"Cardiology Department and Unidad de Cardiopat\u00edas Familiares, Muerte S\u00fabita y Mecanismos de Enfermedad (CaFaMuSMe), Hospital Universitario y Polit\u00e9cnico La Fe and Instituto de Investigaci\u00f3n Sanitaria La Fe, Valencia, Spain (E.Z.)."},{"name":"Center for Biomedical Network Research on Cardiovascular diseases (CIBERCV), Madrid, Spain (E.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyros","family":"Zissimopoulos","sequence":"additional","affiliation":[{"name":"Swansea University Medical School, Institute of Life Science, Swansea, SA2 8PP, UK (C.R.d.M., Y.Z., S.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0213-7591","authenticated-orcid":true,"given":"Feliciano","family":"Protasi","sequence":"additional","affiliation":[{"name":"CAST, Department of Neuroscience, Imaging and Clinical Sciences (DNICS), Medicine and Ageing Sciences (DMSI), University Gabriele d\u2019Annunzio, Chieti, Italy (S.B., F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9866-9081","authenticated-orcid":true,"given":"Jean-Pierre","family":"Benitah","sequence":"additional","affiliation":[{"name":"Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Universit\u00e9 Paris-Saclay 92296 Ch\u00e2tenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0009-2884","authenticated-orcid":true,"given":"Ana M.","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Universit\u00e9 Paris-Saclay 92296 Ch\u00e2tenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2007.06.023"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.91.5.1512"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah5324"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.08.115"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0419"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706573104"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1419795112"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.177493"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.075382"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000192146.85173.4b"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000132472.98675.EC"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303391"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.209312"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu240"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2014.04.023"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.08.022"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12024"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.70.1402"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(02)01946-0"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.4065\/79.11.1380"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.08.132"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1107\/S1399004714020343"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12581"},{"key":"e_1_3_7_25_2","doi-asserted-by":"crossref","unstructured":"Bates D M\u00e4chler M Bolker B Walker S. Fitting linear mixed-effects models using lme4. Journal of Statistical Software. 2015;67:48.","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1145\/1978942.1978963"},{"key":"e_1_3_7_27_2","article-title":"An aligned rank transform procedure for multifactor contrast tests.","author":"Elkin LA","unstructured":"Elkin, LA, Kay, M, Higgins, JJ, Wobbrock, JO. An aligned rank transform procedure for multifactor contrast tests. arXiv. Preprint posted online February 23, 2021.","journal-title":"arXiv"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.91872"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.70.3.445"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5313.800"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3201.092285"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0022"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2017.04.005"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.196873"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(03)00434-3"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29128"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt023"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200709907"},{"key":"e_1_3_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2013.03.058"},{"key":"e_1_3_7_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)80847-8"},{"key":"e_1_3_7_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.045791"},{"key":"e_1_3_7_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa043"},{"key":"e_1_3_7_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1097-2765(00)00003-4"},{"key":"e_1_3_7_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.10.021"},{"key":"e_1_3_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2013.06.012"},{"key":"e_1_3_7_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(04)74271-X"},{"key":"e_1_3_7_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.06.052"},{"key":"e_1_3_7_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.11.019"},{"key":"e_1_3_7_49_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.149609"},{"key":"e_1_3_7_50_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.274803"},{"key":"e_1_3_7_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)32455-4"},{"key":"e_1_3_7_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-010-0839-8"},{"key":"e_1_3_7_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(99)77000-1"},{"key":"e_1_3_7_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00712033"},{"key":"e_1_3_7_55_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.107.6.2587"},{"key":"e_1_3_7_56_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.66.1.31"},{"key":"e_1_3_7_57_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.15.3.481"},{"key":"e_1_3_7_58_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201511366"},{"key":"e_1_3_7_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020863"},{"key":"e_1_3_7_60_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019807"},{"key":"e_1_3_7_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2016.07.002"},{"key":"e_1_3_7_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv231"},{"key":"e_1_3_7_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.150"},{"key":"e_1_3_7_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471142905.hg2103s87"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.121.319094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:56:12Z","timestamp":1715561772000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.121.319094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,23]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,7,23]]}},"alternative-id":["10.1161\/CIRCRESAHA.121.319094"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.121.319094","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,23]]},"assertion":[{"value":"2021-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}