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This review focuses on the ASCVD implications of immune dysregulation due to disorders with varying global prevalence by sex: autoimmune disorders (female predominant), HIV (male-female equivalent), and hepatitis C virus (male predominant). Factors contributing to ASCVD in women with immune disorders, including traditional risk factors, dysregulated innate and adaptive immunity, sex hormones, and treatment modalities, are discussed. Finally, the need to develop new ASCVD risk stratification tools that incorporate variables specific to populations with chronic immune disorders, particularly in women, is emphasized.<\/jats:p>","DOI":"10.1161\/circresaha.121.319877","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T19:00:20Z","timestamp":1645124420000},"page":"593-610","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["Cardiovascular Implications of Immune Disorders in Women"],"prefix":"10.1161","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8436-0465","authenticated-orcid":true,"given":"Caitlin A.","family":"Moran","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases (C.A.M., L.F.C., I.O., C.D.L.), Emory University School of Medicine, Atlanta, 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