{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:17:51Z","timestamp":1792516671880,"version":"4.5.0"},"reference-count":115,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2022,7,8]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Epigenetic dysregulation has been proposed as a key mechanism for arsenic-related cardiovascular disease (CVD). We evaluated differentially methylated positions (DMPs) as potential mediators on the association between arsenic and CVD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              Blood DNA methylation was measured in 2321 participants (mean age 56.2, 58.6% women) of the Strong Heart Study, a prospective cohort of American Indians. Urinary arsenic species were measured using high-performance liquid chromatography coupled to inductively coupled plasma mass spectrometry. We identified DMPs that are potential mediators between arsenic and CVD. In a cross-species analysis, we compared those DMPs with differential liver DNA methylation following early-life arsenic exposure in the apoE knockout (apoE\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              ) mouse model of atherosclerosis.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>A total of 20 and 13 DMPs were potential mediators for CVD incidence and mortality, respectively, several of them annotated to genes related to diabetes. Eleven of these DMPs were similarly associated with incident CVD in 3 diverse prospective cohorts (Framingham Heart Study, Women\u2019s Health Initiative, and Multi-Ethnic Study of Atherosclerosis). In the mouse model, differentially methylated regions in 20 of those genes and DMPs in 10 genes were associated with arsenic.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Differential DNA methylation might be part of the biological link between arsenic and CVD. The gene functions suggest that diabetes might represent a relevant mechanism for arsenic-related cardiovascular risk in populations with a high burden of diabetes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circresaha.122.320991","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T09:00:11Z","timestamp":1654506011000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":61,"title":["Arsenic Exposure, Blood DNA Methylation, and Cardiovascular Disease"],"prefix":"10.1161","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6928-8290","authenticated-orcid":true,"given":"Arce","family":"Domingo-Relloso","sequence":"first","affiliation":[{"name":"Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY (A.D.-R., R.A.G., K.S., M.G.-F., T.R.S., A.N.-A.)."},{"name":"Integrative Epidemiology Group, Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institute, Madrid, Spain (A.D.-R., M.T.-P., M.G.-F.)."},{"name":"Department of Statistics and Operations Research (A.D.-R.), University of Valencia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Makhani","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada (K.M., K.O.K., K.K.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6300-3338","authenticated-orcid":true,"given":"Angela L.","family":"Riffo-Campos","sequence":"additional","affiliation":[{"name":"Department of Computer Science, ETSE (A.L.R.-C.), University of Valencia, Spain."},{"name":"Millennium Nucleus on Sociomedicine (SocioMed) and Vicerrector\u00eda Acad\u00e9mica, Universidad de La Frontera, Temuco, Chile (A.L.R.-C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3850-1228","authenticated-orcid":true,"given":"Maria","family":"Tellez-Plaza","sequence":"additional","affiliation":[{"name":"Integrative Epidemiology Group, Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institute, Madrid, Spain (A.D.-R., M.T.-P., M.G.-F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen Oros","family":"Klein","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada (K.M., K.O.K., K.K.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Subedi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville (P.S., J.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville (P.S., J.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (K.A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-5767","authenticated-orcid":true,"given":"Anne K.","family":"Bozack","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, School of Public Health, University of California, Berkeley (A.K.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3067-3575","authenticated-orcid":true,"given":"Karin","family":"Haack","sequence":"additional","affiliation":[{"name":"Population Health Program, Texas Biomedical Research Institute, San Antonio\u201a TX (K.H., J.W.K., S.A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0142-9373","authenticated-orcid":true,"given":"Walter","family":"Goessler","sequence":"additional","affiliation":[{"name":"Institute of Chemistry - Analytical Chemistry for Health and Environment, University of Graz, Austria (W.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2746-3350","authenticated-orcid":true,"given":"Jason G.","family":"Umans","sequence":"additional","affiliation":[{"name":"MedStar Health Research Institute, Hyattsville, MD. 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