{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:34:07Z","timestamp":1787884447397,"version":"build-2784847793"},"reference-count":115,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2025,2,14]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Calcific aortic valve disease is the pathological remodeling of valve leaflets. The initial steps in valve leaflet osteogenic reprogramming are not fully understood. As TERT (telomerase reverse transcriptase) overexpression primes mesenchymal stem cells to differentiate into osteoblasts, we investigated whether TERT contributes to the osteogenic reprogramming of valve interstitial cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      Human control and calcific aortic valve disease aortic valve leaflets and patient-specific human aortic valve interstitial cells were used in in vivo and in vitro calcification assays. Loss of function experiments in human aortic valve interstitial cells and cells isolated from\n                      <jats:italic>Tert<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      and\n                      <jats:italic>Terc<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      mice were used for mechanistic studies. Calcification was assessed in\n                      <jats:italic>Tert<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>+\/+<\/jats:italic>\n                      <\/jats:sup>\n                      and\n                      <jats:italic>Tert<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      mice ex vivo and in vivo. In silico modeling, proximity ligation, and coimmunoprecipitation assays defined novel TERT interacting partners. Chromatin immunoprecipitation and cleavage under targets and tagmentation sequencing defined protein-DNA interactions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      TERT protein was highly expressed in calcified valve leaflets without changes in telomere length, DNA damage, or senescence markers, and these features were retained in isolated primary human aortic valve interstitial cells.\n                      <jats:italic>TERT<\/jats:italic>\n                      expression increased with osteogenic or inflammatory stimuli, and knockdown or genetic deletion of\n                      <jats:italic>TERT<\/jats:italic>\n                      prevented calcification in vitro and in vivo. Mechanistically, TERT was upregulated via NF-\u03baB (nuclear factor-kappa B) and required to initiate osteogenic reprogramming, independent of its canonical reverse transcriptase activity and the long noncoding RNA\n                      <jats:italic>TERC<\/jats:italic>\n                      . TERT exerts non-canonical osteogenic functions via binding with STAT5 (signal transducer and activator of transcription 5). Depletion or inhibition of STAT5 prevented calcification. STAT5 was found to bind the promoter region of RUNX2 (runt-related transcription factor 2), the master regulator of osteogenic reprogramming. Finally, we demonstrate that TERT and STAT5 are upregulated and colocalized in calcific aortic valve disease tissue compared with control tissue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>TERT\u2019s non-canonical activity is required to initiate calcification. TERT is upregulated via inflammatory signaling pathways and partners with STAT5 to bind the RUNX2 gene promoter. These data identify a novel mechanism and potential therapeutic target to decrease vascular calcification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circresaha.122.321889","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T05:00:16Z","timestamp":1737435616000},"page":"403-421","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Non-Canonical TERT Activity Initiates Osteogenesis in Calcific Aortic Valve Disease"],"prefix":"10.1161","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3571-5845","authenticated-orcid":true,"given":"Rolando A.","family":"Cuevas","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA (R.A.C., C.C.C., R.W., A.C., C.K.B., C.R., W.J.M., M.J. Bashline, A.P., A.M.P., P.B., M.J.B., C.S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Hortells","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Group, Department of Medical Biology, Faculty of Health Science, UiT-The Arctic University of Norway, 9019 Troms\u00f8, Norway (L.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1735-5137","authenticated-orcid":true,"given":"Claire C.","family":"Chu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA (R.A.C., C.C.C., R.W., A.C., C.K.B., C.R., W.J.M., M.J. Bashline, A.P., A.M.P., P.B., M.J.B., C.S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1251-758X","authenticated-orcid":true,"given":"Ryan","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA (R.A.C., C.C.C., R.W., A.C., C.K.B., C.R., W.J.M., M.J. Bashline, A.P., A.M.P., P.B., M.J.B., C.S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Crane","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA (R.A.C., C.C.C., R.W., A.C., C.K.B., C.R., W.J.M., M.J. Bashline, A.P., A.M.P., P.B., M.J.B., C.S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1019-9431","authenticated-orcid":true,"given":"Camille K.","family":"Boufford","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA (R.A.C., C.C.C., R.W., A.C., C.K.B., C.R., W.J.M., M.J. Bashline, A.P., A.M.P., P.B., M.J.B., C.S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cailyn","family":"Regan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA (R.A.C., C.C.C., R.W., A.C., C.K.B., C.R., W.J.M., M.J. Bashline, A.P., A.M.P., P.B., M.J.B., C.S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"William J.","family":"Moorhead","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA (R.A.C., C.C.C., R.W., A.C., C.K.B., C.R., W.J.M., M.J. Bashline, A.P., A.M.P., P.B., M.J.B., C.S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6686-8978","authenticated-orcid":true,"given":"Michael J.","family":"Bashline","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA (R.A.C., C.C.C., R.W., A.C., C.K.B., C.R., W.J.M., M.J. Bashline, A.P., A.M.P., P.B., M.J.B., C.S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4256-9345","authenticated-orcid":true,"given":"Aneesha","family":"Parwal","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA (R.A.C., C.C.C., R.W., A.C., C.K.B., C.R., W.J.M., M.J. Bashline, A.P., A.M.P., P.B., M.J.B., C.S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0207-2510","authenticated-orcid":true,"given":"Angelina M.","family":"Parise","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA (R.A.C., C.C.C., R.W., A.C., C.K.B., C.R., W.J.M., M.J. Bashline, A.P., A.M.P., P.B., M.J.B., C.S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3807-1109","authenticated-orcid":true,"given":"Parya","family":"Behzadi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA (R.A.C., C.C.C., R.W., A.C., C.K.B., C.R., W.J.M., M.J. Bashline, A.P., A.M.P., P.B., M.J.B., C.S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3874-1352","authenticated-orcid":true,"given":"Mark J.","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA (R.A.C., C.C.C., R.W., A.C., C.K.B., C.R., W.J.M., M.J. Bashline, A.P., A.M.P., P.B., M.J.B., C.S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4338-0624","authenticated-orcid":true,"given":"Aditi U.","family":"Gurkar","sequence":"additional","affiliation":[{"name":"Aging Institute, Division of Geriatrics, Department of Medicine, University of Pittsburgh, Pittsburgh, PA (A.U.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Bruemmer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH (D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4108-803X","authenticated-orcid":true,"given":"John","family":"Sembrat","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA (J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1737-4012","authenticated-orcid":true,"given":"Ibrahim","family":"Sultan","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Cardiothoracic Surgery, Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA (I.S., T.G.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5858-6073","authenticated-orcid":true,"given":"Thomas G.","family":"Gleason","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Cardiothoracic Surgery, Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA (I.S., T.G.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7591-0362","authenticated-orcid":true,"given":"Marie","family":"Billaud","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Cardiac Surgery, Brigham and Women's Hospital &amp; Harvard Medical School, Boston, MA (M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1871-6915","authenticated-orcid":true,"given":"Cynthia","family":"St. Hilaire","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA (R.A.C., C.C.C., R.W., A.C., C.K.B., C.R., W.J.M., M.J. Bashline, A.P., A.M.P., P.B., M.J.B., C.S.H.)."},{"name":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA (C.S.H.)."},{"name":"Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA (C.S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab757"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001254"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.660797"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00570-z"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000757"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.006767"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.234237"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070251"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000070591.21548.69"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.237610"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.027776"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.302071"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0903373"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182407599"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0040010"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503095102"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08137"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2016.01.002"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.308717"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0602-587"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0602-592"},{"key":"e_1_3_3_24_2","first-page":"876","article-title":"Genetic determination of telomere size in humans: a twin study of three age groups.","volume":"55","author":"Slagboom PE","year":"1994","unstructured":"Slagboom PE, Droog S, Boomsma DI. Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet. 1994;55:876\u2013882.","journal-title":"Am J Hum Genet"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000067426.96344.32"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05633-1"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000222961.24912.69"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.217158"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00004.2022"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213250"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.16.1.293"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00791-1"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204807"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0117-x"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0422"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1380"},{"key":"e_1_3_3_37_2","first-page":"4006","article-title":"Stat5a promotes Col10a1 gene expression during chondrocyte hypertrophic differentiation.","volume":"15","author":"Wu X","year":"2023","unstructured":"Wu X, Chen C, Han T, Bian H, Chen J, Hei R, Meng Y, Wu C, Lu Y, Gu J, et al. Stat5a promotes Col10a1 gene expression during chondrocyte hypertrophic differentiation. Am J Transl Res. 2023;15:4006\u20134019.","journal-title":"Am J Transl Res"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.3791\/62439"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2011.04.004"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2014.07.005"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.3791\/62419"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.patbio.2008.06.004"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201266200"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.10.e47"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)80257-3"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)80259-7"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.267237"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.03.020"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311504"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.04.014"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232565"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaf9109"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.313765"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep32659"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.633465"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7605428"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.11.020"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.213074"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0872-9"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/6010"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/416036"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.34.21096"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2020.08.036"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000218271.93076.c3"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1348\/000712608X377117"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.16.7024-7031.2004"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02351-6"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7544491"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0234-z"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2621"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw549"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-108"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/24.1.238"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.03.008"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201904147"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201410672"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0502-473"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07283"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507682200"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0312-x"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab314"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10855-0"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.68"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.241505"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20471"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090502"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108294"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.9.8367"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac194"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00093-14"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015171108"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.186205"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.302523"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000032872.55215.05"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00027"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49016-0"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314789"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90249-z"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047477"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1184-7"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.36.25343"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.3.1723"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.11.8114"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2011.02.005"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-11-0850"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.07.002"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.2.609"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.302610"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/364310"},{"key":"e_1_3_3_112_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2009.0174"},{"key":"e_1_3_3_113_2","doi-asserted-by":"publisher","DOI":"10.1615\/jlongtermeffmedimplants.2015011748"},{"key":"e_1_3_3_114_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20210"},{"key":"e_1_3_3_115_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.687210"},{"key":"e_1_3_3_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.06.049"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.122.321889","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T14:00:49Z","timestamp":1739455249000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.122.321889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,14]]},"references-count":115,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,2,14]]}},"alternative-id":["10.1161\/CIRCRESAHA.122.321889"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.122.321889","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.08.23.504425","asserted-by":"object"}]},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,14]]},"assertion":[{"value":"2022-08-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-05","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}