{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:16:36Z","timestamp":1789035396418,"version":"build-2803163510"},"reference-count":223,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2023,6,9]]},"abstract":"<jats:p>The growing epidemics of obesity, hypertension, and diabetes, in addition to worsening environmental factors such as air pollution, water scarcity, and climate change, have fueled the continuously increasing prevalence of cardiovascular diseases (CVDs). This has caused a markedly increasing burden of CVDs that includes mortality and morbidity worldwide. Identification of subclinical CVD before overt symptoms can lead to earlier deployment of preventative pharmacological and nonpharmacologic strategies. In this regard, noninvasive imaging techniques play a significant role in identifying early CVD phenotypes. An armamentarium of imaging techniques including vascular ultrasound, echocardiography, magnetic resonance imaging, computed tomography, noninvasive computed tomography angiography, positron emission tomography, and nuclear imaging, with intrinsic strengths and limitations can be utilized to delineate incipient CVD for both clinical and research purposes. In this article, we review the various imaging modalities used for the evaluation, characterization, and quantification of early subclinical cardiovascular diseases.<\/jats:p>","DOI":"10.1161\/circresaha.123.322054","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T18:00:33Z","timestamp":1686247233000},"page":"1607-1627","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Imaging Early Life Cardiovascular Phenotype"],"prefix":"10.1161","volume":"132","author":[{"given":"Vinithra","family":"Varadarajan","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine Johns Hopkins University, Baltimore, MD (V.V., J.A.C.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8557-7225","authenticated-orcid":true,"given":"Samuel S.","family":"Gidding","sequence":"additional","affiliation":[{"name":"Department of Genomic Health, Geisinger, Danville, PA (S.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Heart, Lung and Blood Institute, Bethesda, MD (C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4398-8237","authenticated-orcid":true,"given":"J. Jeffrey","family":"Carr","sequence":"additional","affiliation":[{"name":"Department Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN (J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8756-6995","authenticated-orcid":true,"given":"Joao A.C.","family":"Lima","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Johns Hopkins University, Baltimore, MD (V.V., J.A.C.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2016.10.005"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.053"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001052"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp048024"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198601163140302"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009778"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00032.2006"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci117980"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn153"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024534"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.AAU7779\/ASSET\/5EC65A18-D123-47B7-91ED-45C618AA0229\/ASSETS\/GRAPHIC\/361_552_F1.JPEG"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCMG.2016.02.027"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.628875"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.07.053"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1148\/RADIOL.220122"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61177-6"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.717033"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.7555\/JBR.29.20140087"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024503"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199806043382302"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.8.727"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.8.883"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-117"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043430"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.537878"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116963"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACC.2008.09.061"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.966465"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.12.017"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.17.2277"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1995.tb03476.x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.98.23.2580"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.17.2271"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9150(99)00479-7"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000178991.71605.18"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.94.5.1175"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.743161"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017205"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/S41598-018-22292-Y"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.0000258865.44774.41"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.97.23.2307"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.20.5.1262"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306247"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.023511"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.210122"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2020.11.001"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.92.8.2157"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(97)00443-9"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.05.027"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.049"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.01.022"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs230"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.5493"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.02.051"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.21.5.852"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.03.009"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.285122"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.05.039"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000148322.89911.44"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.1.48"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-013-0652-x"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.10.041"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.119.009228"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.115.018042"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.21.2341"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.08.038"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.003533"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.114.002179"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.055340"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.03.001"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60291-4"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.08.058"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS16023740"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.07.072"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1093\/EURHEARTJ\/EHT488"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2021.4406"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021203179"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2020.08.025"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-022-08619-4"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.8643"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100886"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2007.01597.x"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.12.1344"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.74.6.1399"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-128-4-199802150-00002"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.9.1310"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.96.5.1432"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.800235"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901073400103"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(02)02660-7"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.173609"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2013.12.015"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.566596"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.28.11.2201"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841850802438520"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1002\/CLC.22934"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(60)90318-0"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15394"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.21.2503"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000028591.44554.f9"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1081\/jcmr-100108587"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.8665"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311756"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2212001612"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.08.032"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000120708.59903.1B"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.003144"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018180562"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.05.011"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2341040439"},{"key":"e_1_3_3_112_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-047645"},{"key":"e_1_3_3_113_2","doi-asserted-by":"publisher","DOI":"10.4082\/kjfm.2013.34.3.213"},{"key":"e_1_3_3_114_2","doi-asserted-by":"publisher","DOI":"10.4082\/kjfm.17.0098"},{"key":"e_1_3_3_115_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023037"},{"key":"e_1_3_3_116_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487320919895"},{"key":"e_1_3_3_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.12.004"},{"key":"e_1_3_3_118_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra061889"},{"key":"e_1_3_3_119_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-010-9255-x"},{"key":"e_1_3_3_120_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023207"},{"key":"e_1_3_3_121_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq039"},{"key":"e_1_3_3_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2018.12.038"},{"key":"e_1_3_3_123_2","first-page":"184","article-title":"Coronary microvascular dysfunction in Takotsubo syndrome: cause or consequence.","volume":"11","author":"Y-Hassan S","year":"2021","unstructured":"Y-Hassan, S. Coronary microvascular dysfunction in Takotsubo syndrome: cause or consequence. Am J Cardiovasc Dis. 2021;11:184\u2013193.","journal-title":"Am J Cardiovasc Dis"},{"key":"e_1_3_3_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.042"},{"key":"e_1_3_3_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2014.12.008"},{"key":"e_1_3_3_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.05.051"},{"key":"e_1_3_3_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.07.106"},{"key":"e_1_3_3_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(96)00017-4"},{"key":"e_1_3_3_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(97)00029-6"},{"key":"e_1_3_3_130_2","doi-asserted-by":"publisher","DOI":"10.1148\/RADIOL.14140806"},{"key":"e_1_3_3_131_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew044"},{"key":"e_1_3_3_132_2","doi-asserted-by":"publisher","DOI":"10.21037\/cdt.2017.06.11"},{"key":"e_1_3_3_133_2","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e318124a884"},{"key":"e_1_3_3_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.05.004"},{"key":"e_1_3_3_135_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21020"},{"key":"e_1_3_3_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.01.005"},{"key":"e_1_3_3_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.02.061"},{"key":"e_1_3_3_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.053"},{"key":"e_1_3_3_139_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.114.002481"},{"key":"e_1_3_3_140_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.109.854893"},{"key":"e_1_3_3_141_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40336-014-0070-2"},{"key":"e_1_3_3_142_2","first-page":"1848","article-title":"Assessment of the reproducibility of baseline and hyperemic myocardial blood flow measurements with 15O-labeled water and PET.","volume":"40","author":"Kaufmann PA","year":"1999","unstructured":"Kaufmann, PA, Gnecchi-Ruscone, T, Yap, JT, Rimoldi, O, Camici, PG. Assessment of the reproducibility of baseline and hyperemic myocardial blood flow measurements with 15O-labeled water and PET. J Nucl Med. 1999;40:1848\u20131856. Accessed October 18, 2022. https:\/\/jnm.snmjournals.org\/content\/40\/11\/1848.","journal-title":"J Nucl Med"},{"key":"e_1_3_3_143_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.104.007831"},{"key":"e_1_3_3_144_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac013"},{"key":"e_1_3_3_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.08.048"},{"key":"e_1_3_3_146_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.83"},{"key":"e_1_3_3_147_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.09.002"},{"key":"e_1_3_3_148_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa052256"},{"key":"e_1_3_3_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2019.07.538"},{"key":"e_1_3_3_150_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002477"},{"key":"e_1_3_3_151_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.302922"},{"key":"e_1_3_3_152_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.313572"},{"key":"e_1_3_3_153_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.587519"},{"key":"e_1_3_3_154_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeab154"},{"key":"e_1_3_3_155_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/27.3.341"},{"key":"e_1_3_3_156_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1349-6"},{"key":"e_1_3_3_157_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306565"},{"key":"e_1_3_3_158_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14131971"},{"key":"e_1_3_3_159_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew332"},{"key":"e_1_3_3_160_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.114.002769"},{"key":"e_1_3_3_161_2","doi-asserted-by":"publisher","DOI":"10.1002\/EHF2.12559"},{"key":"e_1_3_3_162_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.006547"},{"key":"e_1_3_3_163_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCHF.2021.06.016"},{"key":"e_1_3_3_164_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-017-0367-1"},{"key":"e_1_3_3_165_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25135"},{"key":"e_1_3_3_166_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.093146"},{"key":"e_1_3_3_167_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03697"},{"key":"e_1_3_3_168_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.108.819938"},{"key":"e_1_3_3_169_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2011.08.011"},{"key":"e_1_3_3_170_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs341"},{"key":"e_1_3_3_171_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.154"},{"key":"e_1_3_3_172_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(02)01973-3"},{"key":"e_1_3_3_173_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.92.3.380"},{"key":"e_1_3_3_174_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2020.11.002"},{"key":"e_1_3_3_175_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.000450"},{"key":"e_1_3_3_176_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00118-j"},{"key":"e_1_3_3_177_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jey123"},{"key":"e_1_3_3_178_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.03.010"},{"key":"e_1_3_3_179_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.08.052"},{"key":"e_1_3_3_180_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.614532"},{"key":"e_1_3_3_181_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.04.042"},{"key":"e_1_3_3_182_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23763"},{"key":"e_1_3_3_183_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.92.3.380"},{"key":"e_1_3_3_184_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20865"},{"key":"e_1_3_3_185_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.004299"},{"key":"e_1_3_3_186_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2014.01.016"},{"key":"e_1_3_3_187_2","doi-asserted-by":"publisher","DOI":"10.1093\/EHJCI\/JEAB266"},{"key":"e_1_3_3_188_2","doi-asserted-by":"publisher","DOI":"10.1093\/EHJCI\/JEU018"},{"key":"e_1_3_3_189_2","doi-asserted-by":"publisher","DOI":"10.1186\/S12968-017-0327-9\/FIGURES\/5"},{"key":"e_1_3_3_190_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185114"},{"key":"e_1_3_3_191_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.110.208280"},{"key":"e_1_3_3_192_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02381-0"},{"key":"e_1_3_3_193_2","doi-asserted-by":"publisher","DOI":"10.1161\/hy0302.104674"},{"key":"e_1_3_3_194_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.013"},{"key":"e_1_3_3_195_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2012.158"},{"key":"e_1_3_3_196_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.02.006"},{"key":"e_1_3_3_197_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.159"},{"key":"e_1_3_3_198_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27454"},{"key":"e_1_3_3_199_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-015-0152-y"},{"key":"e_1_3_3_200_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpab018"},{"key":"e_1_3_3_201_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.210315"},{"key":"e_1_3_3_202_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17339"},{"key":"e_1_3_3_203_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.704611"},{"key":"e_1_3_3_204_2","doi-asserted-by":"publisher","DOI":"10.3389\/FCVM.2022.1066849"},{"key":"e_1_3_3_205_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.06.036"},{"key":"e_1_3_3_206_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.02.060"},{"key":"e_1_3_3_207_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2022.06.017"},{"key":"e_1_3_3_208_2","doi-asserted-by":"publisher","DOI":"10.1093\/EURHEARTJ\/EHAC544.095"},{"key":"e_1_3_3_209_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.001593"},{"key":"e_1_3_3_210_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311312"},{"key":"e_1_3_3_211_2","doi-asserted-by":"publisher","DOI":"10.1198\/jasa.2009.tm08622"},{"key":"e_1_3_3_212_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311312"},{"key":"e_1_3_3_213_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174944.t004"},{"key":"e_1_3_3_214_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-019-0575-y"},{"key":"e_1_3_3_215_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeab119"},{"key":"e_1_3_3_216_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.119.009214"},{"key":"e_1_3_3_217_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac700"},{"key":"e_1_3_3_218_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61350-5"},{"key":"e_1_3_3_219_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa054013"},{"key":"e_1_3_3_220_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.AMJMED.2019.10.020"},{"key":"e_1_3_3_221_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.06.030"},{"key":"e_1_3_3_222_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.045851"},{"key":"e_1_3_3_223_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2013.03.004"},{"key":"e_1_3_3_224_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.009"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.123.322054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T04:48:40Z","timestamp":1715575720000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.123.322054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,9]]},"references-count":223,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,6,9]]}},"alternative-id":["10.1161\/CIRCRESAHA.123.322054"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.123.322054","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,9]]},"assertion":[{"value":"2023-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}