{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:42:50Z","timestamp":1790066570517,"version":"4.0.1"},"reference-count":77,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2024,1,19]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Diabetes is a major risk factor for atherosclerotic cardiovascular diseases with a 2-fold higher risk of cardiovascular events in people with diabetes compared with those without. Circulating monocytes are inflammatory effector cells involved in both type 2 diabetes (T2D) and atherogenesis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>We investigated the relationship between circulating monocytes and cardiovascular risk progression in people with T2D, using phenotypic, transcriptomic, and metabolomic analyses. cardiovascular risk progression was estimated with coronary artery calcium score in a cohort of 672 people with T2D.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>Coronary artery calcium score was positively correlated with blood monocyte count and frequency of the classical monocyte subtype. Unsupervised k-means clustering based on monocyte subtype profiles revealed 3 main endotypes of people with T2D at varying risk of cardiovascular events. These observations were confirmed in a validation cohort of 279 T2D participants. The predictive association between monocyte count and major adverse cardiovascular events was validated through an independent prospective cohort of 757 patients with T2D. Integration of monocyte transcriptome analyses and plasma metabolomes showed a disruption of mitochondrial pathways (tricarboxylic acid cycle, oxidative phosphorylation pathway) that underlined a proatherogenic phenotype.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>In this study, we provide evidence that frequency and monocyte phenotypic profile are closely linked to cardiovascular risk in patients with T2D. The assessment of monocyte frequency and count is a valuable predictive marker for risk of cardiovascular events in patients with T2D.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT04353869\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circresaha.123.322757","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T05:01:00Z","timestamp":1703739660000},"page":"189-202","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Blood Monocyte Phenotype Is A Marker of Cardiovascular Risk in Type 2 Diabetes"],"prefix":"10.1161","volume":"134","clinical-trial-number":[{"clinical-trial-number":"nct04353869","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4497-5710","authenticated-orcid":true,"given":"Jean-Baptiste","family":"Julla","sequence":"first","affiliation":[{"name":"INSERM, Necker Enfants Malades (INEM), INSERM U1151, CNRS UMR 8253, IMMEDIAB Laboratory (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., I.N., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Cordeliers Research Centre, INSERM, IMMEDIAB Laboratory, Sorbonne Universit\u00e9 (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Diabetes Institute (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., T.V.-T., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Diabetology, Endocrinology and Nutrition Department, Lariboisi\u00e8re Hospital, F\u00e9d\u00e9ration de Diab\u00e9tologie, France (J.-B.J., T.V.-T., J.-P.R., J.-F.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Girard","sequence":"additional","affiliation":[{"name":"INSERM, Necker Enfants Malades (INEM), INSERM U1151, CNRS UMR 8253, IMMEDIAB Laboratory (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., I.N., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Cordeliers Research Centre, INSERM, IMMEDIAB Laboratory, Sorbonne Universit\u00e9 (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Diabetes Institute (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., T.V.-T., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Diedisheim","sequence":"additional","affiliation":[{"name":"INSERM, Necker Enfants Malades (INEM), INSERM U1151, CNRS UMR 8253, IMMEDIAB Laboratory (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., I.N., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Cordeliers Research Centre, INSERM, IMMEDIAB Laboratory, Sorbonne Universit\u00e9 (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Diabetes Institute (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., T.V.-T., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Clinique Saint Gatien Alliance (NCT+), Saint-Cyr-sur-Loire, France (M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1862-4252","authenticated-orcid":true,"given":"Pierre-Jean","family":"Saulnier","sequence":"additional","affiliation":[{"name":"Poitiers Universit\u00e9, CHU Poitiers, INSERM, Centre d\u2019Investigation Clinique CIC1402, Poitiers, France (P.-J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4036-9876","authenticated-orcid":true,"given":"Bao","family":"Tran Vuong","sequence":"additional","affiliation":[{"name":"INSERM, Necker Enfants Malades (INEM), INSERM U1151, CNRS UMR 8253, IMMEDIAB Laboratory (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., I.N., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Cordeliers Research Centre, INSERM, IMMEDIAB Laboratory, Sorbonne Universit\u00e9 (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Diabetes Institute (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., T.V.-T., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4298-2888","authenticated-orcid":true,"given":"Camille","family":"Bl\u00e9riot","sequence":"additional","affiliation":[{"name":"INSERM, Necker Enfants Malades (INEM), INSERM U1151, CNRS UMR 8253, IMMEDIAB Laboratory (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., I.N., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Cordeliers Research Centre, INSERM, IMMEDIAB Laboratory, Sorbonne Universit\u00e9 (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Diabetes Institute (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., T.V.-T., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2812-1886","authenticated-orcid":true,"given":"Elena","family":"Carcarino","sequence":"additional","affiliation":[{"name":"INSERM, Necker Enfants Malades (INEM), INSERM U1151, CNRS UMR 8253, IMMEDIAB Laboratory (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., I.N., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Cordeliers Research Centre, INSERM, IMMEDIAB Laboratory, Sorbonne Universit\u00e9 (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Diabetes Institute (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., T.V.-T., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0821-4540","authenticated-orcid":true,"given":"Joe","family":"De Keizer","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax, Nantes, France (J.D.K., S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Orliaguet","sequence":"additional","affiliation":[{"name":"INSERM, Necker Enfants Malades (INEM), INSERM U1151, CNRS UMR 8253, IMMEDIAB Laboratory (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., I.N., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Cordeliers Research Centre, INSERM, IMMEDIAB Laboratory, Sorbonne Universit\u00e9 (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Diabetes Institute (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., T.V.-T., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8080-839X","authenticated-orcid":true,"given":"Ivan","family":"Nemazanyy","sequence":"additional","affiliation":[{"name":"INSERM, Necker Enfants Malades (INEM), INSERM U1151, CNRS UMR 8253, IMMEDIAB Laboratory (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., I.N., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charline","family":"Potier","sequence":"additional","affiliation":[{"name":"INSERM, Necker Enfants Malades (INEM), INSERM U1151, CNRS UMR 8253, IMMEDIAB Laboratory (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., I.N., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Cordeliers Research Centre, INSERM, IMMEDIAB Laboratory, Sorbonne Universit\u00e9 (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Diabetes Institute (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., T.V.-T., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7508-9172","authenticated-orcid":true,"given":"Kennan","family":"Khider","sequence":"additional","affiliation":[{"name":"INSERM, Necker Enfants Malades (INEM), INSERM U1151, CNRS UMR 8253, IMMEDIAB Laboratory (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., I.N., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Cordeliers Research Centre, INSERM, IMMEDIAB Laboratory, Sorbonne Universit\u00e9 (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Diabetes Institute (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., T.V.-T., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy Chepngenoh","family":"Tonui","sequence":"additional","affiliation":[{"name":"INSERM, Necker Enfants Malades (INEM), INSERM U1151, CNRS UMR 8253, IMMEDIAB Laboratory (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., I.N., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Cordeliers Research Centre, INSERM, IMMEDIAB Laboratory, Sorbonne Universit\u00e9 (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Diabetes Institute (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., T.V.-T., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Ejlalmanesh","sequence":"additional","affiliation":[{"name":"INSERM, Necker Enfants Malades (INEM), INSERM U1151, CNRS UMR 8253, IMMEDIAB Laboratory (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., I.N., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Cordeliers Research Centre, INSERM, IMMEDIAB Laboratory, Sorbonne Universit\u00e9 (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Diabetes Institute (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., T.V.-T., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphaelle","family":"Ballaire","sequence":"additional","affiliation":[{"name":"INSERM, Necker Enfants Malades (INEM), INSERM U1151, CNRS UMR 8253, IMMEDIAB Laboratory (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., I.N., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Cordeliers Research Centre, INSERM, IMMEDIAB Laboratory, Sorbonne Universit\u00e9 (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."},{"name":"Diabetes Institute (J.-B.J., D.G., M.D., B.T.V., C.B., E.C., L.O., C.P., K.K., D.C.T., T.E., R.B., T.V.-T., J.-P.R., L.P., R.R., C.V., F.A., J.-F.G., N.V.), Universit\u00e9 Paris Cit\u00e9, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1099-9028","authenticated-orcid":true,"given":"Hendrick","family":"Mambu Mambueni","sequence":"additional","affiliation":[{"name":"Genomics platform UFR Simone Veil 1173; U, University of Versailles Paris-Saclay; Inserm UMR 1173 (H.M.M., H.-J.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5992-1275","authenticated-orcid":true,"given":"St\u00e9phane","family":"Germain","sequence":"additional","affiliation":[{"name":"Center for Interdisciplinary Research in Biology (CIRB), College de France, CNRS, INSERM, Universit\u00e9 PSL, Paris, France (S.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4180-158X","authenticated-orcid":true,"given":"B\u00e9n\u00e9dicte","family":"Gaborit","sequence":"additional","affiliation":[{"name":"C2VN, INRAE, INSERM, Aix Marseille University, Marseille, 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