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However, more and more pieces of evidence point to the importance of PIEZO channels in cardiovascular activities and disease development. PIEZO channel-related cardiac functions include transducing hemodynamic forces in endothelial and vascular cells, red blood cell homeostasis, platelet aggregation, and arterial blood pressure regulation, among others. PIEZO channels contribute to pathological conditions including cardiac hypertrophy and pulmonary hypertension and congenital syndromes such as generalized lymphatic dysplasia and xerocytosis. In this review, we highlight recent advances in understanding the role of PIEZO channels in cardiovascular functions and diseases. Achievements in this quickly expanding field should open a new road for efficient control of PIEZO-related diseases in cardiovascular functions.<\/jats:p>","DOI":"10.1161\/circresaha.123.322798","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T14:00:46Z","timestamp":1709215246000},"page":"572-591","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":91,"title":["PIEZO Ion Channels in Cardiovascular Functions and Diseases"],"prefix":"10.1161","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0163-2494","authenticated-orcid":true,"given":"Bertrand","family":"Coste","sequence":"first","affiliation":[{"name":"Centre de Recherche en CardioVasculaire et Nutrition, Aix-Marseille Universit\u00e9 - INSERM 1263 - INRAE 1260, Marseille, 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