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Salt sensitivity of blood pressure is an important risk factor for cardiovascular events, but the phenotype remains unclear because of insufficient understanding of the underlying mechanisms and lack of feasible diagnostic tools. In honor of this centennial, we commemorate the initial discovery of salt sensitivity of blood pressure and chronicle the subsequent scientific discoveries and efforts to mitigate salt-induced cardiovascular disease with American Heart Association leading the way. We also highlight determinants of the pathophysiology of salt sensitivity of blood pressure in humans and recent developments in diagnostic methods and future prospects.<\/jats:p>","DOI":"10.1161\/circresaha.123.322982","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T14:00:46Z","timestamp":1715263246000},"page":"1234-1239","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Salt Sensitivity of Blood Pressure"],"prefix":"10.1161","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8935-5603","authenticated-orcid":true,"given":"Jeremiah","family":"Afolabi","sequence":"first","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (J.A., C.L.L., A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6453-6010","authenticated-orcid":true,"given":"Cheryl L.","family":"Laffer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (J.A., C.L.L., A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4636-2889","authenticated-orcid":true,"given":"Heather K.","family":"Beasley","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN (H.K.B., A.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7730-952X","authenticated-orcid":true,"given":"Antentor","family":"Hinton","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN (H.K.B., A.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4376-5831","authenticated-orcid":true,"given":"Sepiso K.","family":"Masenga","sequence":"additional","affiliation":[{"name":"HAND Research Group (Hypertension, HIV\/AIDS, Nutrition, Diabetes and Dyslipidemia Research Group), School of Medicine and Health Sciences, Mulungushi University, Livingstone, Zambia (S.K.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8580-9359","authenticated-orcid":true,"given":"Annet","family":"Kirabo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (J.A., C.L.L., A.K.)."},{"name":"Vanderbilt Center for Immunobiology, Nashville, TN (A.K.)."},{"name":"Vanderbilt Institute for Infection, Immunology and Inflammation, Nashville, TN (A.K.)."},{"name":"Vanderbilt Institute for Global Health, Nashville, TN (A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000047"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318279acbf"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07289"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2021.0212"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90045-1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.28.5.854"},{"key":"e_1_3_2_8_2","first-page":"179","article-title":"A comparison of two tests for the assessment of blood pressure responses to sodium.","volume":"6","author":"Weinberger MH","year":"1993","unstructured":"Weinberger, MH, Stegner, JE, Fineberg, NS. 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