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In this review, we explore circadian molecular mechanisms and novel therapies, including (1) intense light, (2) small molecules modulating the circadian mechanism, and (3) chronotherapies such as cardiovascular drugs and meal timings. These promise significant clinical translation in circadian medicine for cardiovascular disease. (4) Additionally, we address the differential functioning of the circadian mechanism in males versus females, emphasizing the consideration of biological sex, gender, and aging in circadian therapies for cardiovascular disease.<\/jats:p>","DOI":"10.1161\/circresaha.123.323522","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T18:00:28Z","timestamp":1710439228000},"page":"675-694","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Circadian Influences on Myocardial Ischemia-Reperfusion Injury and Heart Failure"],"prefix":"10.1161","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-4669","authenticated-orcid":true,"given":"Tobias","family":"Eckle","sequence":"first","affiliation":[{"name":"Department of Anesthesiology (T.E., J.B.), University of Colorado Anschutz Medical Campus, Aurora."},{"name":"Division of Cardiology, Department of Medicine (T.E., L.A.W.), 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