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This is due to barriers across the care continuum, including individual-, provider-, and system-level obstacles within the health system. A critical issue is the lack of contextualized mechanistic research to understand the mechanisms, phenotypes, and treatment responses in native SSA populations. Current treatment approaches are often based on data from diaspora Africans, particularly African Americans. Consequently, most guidelines do not recommend angiotensin system drugs as first-line agents for Black patients, a stance that should be reconsidered given some evidence of their effectiveness in native SSA populations. Addressing these barriers requires a comprehensive, multisectoral strategy that includes both preventative and clinical measures at the population and individual levels. Preventative approaches should encompass health and nutrition education, improving food supply quality, and implementing comprehensive transportation and environmental policies. In addition, strategies should be developed to increase the detection of undiagnosed cases through enhanced screening and treatment access to those not receiving care, and revisit current treatment approaches to ensure that they are more tailored to the specific populations and settings. In conclusion, innovative strategies are needed to identify and overcome barriers to hypertension diagnosis and management. A coordinated, multisectoral approach that includes a contextualized mechanistic research agenda, as well as task shifting and task sharing, will help prevent and reduce hypertension in SSA.<\/jats:p>","DOI":"10.1161\/circresaha.124.323889","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T14:00:20Z","timestamp":1750341620000},"page":"106-118","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Hypertension in Sub-Saharan Africa: Burden, Barriers and Priorities for Improving Treatment Outcomes"],"prefix":"10.1161","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5309-5611","authenticated-orcid":true,"given":"Modou","family":"Jobe","sequence":"first","affiliation":[{"name":"Nutrition &amp; Planetary Health Theme, Medical Research Council Unit The Gambia at London School of Hygiene &amp; Tropical Medicine, Banjul (M.J., A.M.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3949-7507","authenticated-orcid":true,"given":"Serigne Mor","family":"Beye","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Formation et de Recherche (UFR) des Sciences de la Sant\u00e9, Universit\u00e9 Gaston Berger de Saint Louis, Senegal (S.M.B., A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4758-9225","authenticated-orcid":true,"given":"Ngone Diaba","family":"Gaye","sequence":"additional","affiliation":[{"name":"Department of Cardiac Rehabilitation, Ibra Mamadou Wane Medical Center, Dakar, Senegal (N.D.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2681-9706","authenticated-orcid":true,"given":"Mame Madjiguene","family":"Ka","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Principal Hospital of Dakar, Senegal (M.M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-301X","authenticated-orcid":true,"given":"Pablo","family":"Perel","sequence":"additional","affiliation":[{"name":"Department of Non-Communicable Disease Epidemiology, London School of Hygiene &amp; 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