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In this review, we systemically summarized and updated the biological functions of arachidonic acid pathways in cardiometabolic diseases, mainly focusing on heart failure, hypertension, atherosclerosis, nonalcoholic fatty liver disease, obesity, and diabetes. We further discussed the cellular and molecular mechanisms of arachidonic acid pathway\u2013mediated regulation of cardiometabolic diseases and highlighted the emerging clinical advances to improve these pathological conditions by targeting arachidonic acid metabolites and pathway factors.<\/jats:p>","DOI":"10.1161\/circresaha.124.324383","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T14:00:44Z","timestamp":1718892044000},"page":"222-260","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":64,"title":["Emerging Roles and Therapeutic Applications of Arachidonic Acid Pathways in Cardiometabolic Diseases"],"prefix":"10.1161","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9416-262X","authenticated-orcid":true,"given":"Yufeng","family":"Hu","sequence":"first","affiliation":[{"name":"State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan 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