{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:20:23Z","timestamp":1792491623465,"version":"4.5.0"},"reference-count":77,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2025,5,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Heart failure with preserved ejection fraction (HFpEF) has overtaken heart failure with reduced ejection fraction as the leading type of heart failure globally and is marked by high morbidity and mortality rates, yet with only a single approved pharmacotherapy: SGLT2i (sodium-glucose co-transporter 2 inhibitor). A prevailing theory for the mechanism underlying SGLT2i is nutrient deprivation signaling, of which ketogenesis is a hallmark. However, it is unclear whether the canonical ketogenic enzyme, HMGCS2 (3-hydroxy-3-methylglutaryl-coenzyme A synthase 2), plays any cardiac role in HFpEF pathogenesis or therapeutic response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We used human myocardium, human HFpEF and heart failure with reduced ejection fraction transcardiac blood sampling, an established murine model of HFpEF, ex vivo Langendorff perfusion, stable isotope tracing in isolated cardiomyocytes, targeted metabolomics, proteomics, lipidomics, and a novel cardiomyocyte-specific conditional HMGCS2-deficient model that we generated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>We demonstrate, for the first time, the intrinsic capacity of the human heart to produce ketones via HMGCS2. We found that increased acetylation of HMGCS2 led to a decrease in the enzyme\u2019s specific activity. However, this was overcome by an increase in the steady-state levels of protein. Oxidized form of nicotinamide adenine dinucleotide repletion restored HMGCS2 function via deacetylation, increased fatty acid oxidation, and rescued cardiac function in HFpEF. Critically, using a conditional, cardiomyocyte-specific HMGCS2 knockdown murine model, we revealed that the oxidized form of nicotinamide adenine dinucleotide is unable to rescue HFpEF in the absence of cardiomyocyte HMGCS2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The canonical ketogenic enzyme, HMGCS2, mediates the therapeutic effects of the oxidized form of nicotinamide adenine dinucleotide repletion in HFpEF by restoring normal lipid metabolism and mitochondrial function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circresaha.124.325550","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T05:01:11Z","timestamp":1744347671000},"page":"1113-1130","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["The Heart Has Intrinsic Ketogenic Capacity that Mediates NAD\n                    <sup>+<\/sup>\n                    Therapy in HFpEF"],"prefix":"10.1161","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6704-5495","authenticated-orcid":true,"given":"Yen Chin","family":"Koay","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences (Y.C.K., B.M., Y.H.N., X.W., Y.H., S.T., A.Y.B., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Cardiometabolic Medicine (Y.C.K., B.M., Y.H.N., X.W., Y.H., P.G.B., S.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Charles Perkins Centre (Y.C.K., B.M., Y.H.N., X.W., Y.H., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9948-0242","authenticated-orcid":true,"given":"Bailey","family":"McIntosh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences (Y.C.K., B.M., Y.H.N., X.W., Y.H., S.T., A.Y.B., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Cardiometabolic Medicine (Y.C.K., B.M., Y.H.N., X.W., Y.H., P.G.B., S.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Charles Perkins Centre (Y.C.K., B.M., Y.H.N., X.W., Y.H., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3913-6429","authenticated-orcid":true,"given":"Yann Huey","family":"Ng","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences (Y.C.K., B.M., Y.H.N., X.W., Y.H., S.T., A.Y.B., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Cardiometabolic Medicine (Y.C.K., B.M., Y.H.N., X.W., Y.H., P.G.B., S.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Charles Perkins Centre (Y.C.K., B.M., Y.H.N., X.W., Y.H., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Medicine, Department of Cardiology, The First Affiliated Hospital of USTC (Y.C.), University of Science and Technology of China (USTC), Hefei."},{"name":"Division of Life Sciences and Medicine, School of Basic Medical Sciences (Y.C.), University of Science and Technology of China (USTC), Hefei."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3487-4614","authenticated-orcid":true,"given":"Xiao Suo","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences (Y.C.K., B.M., Y.H.N., X.W., Y.H., S.T., A.Y.B., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Cardiometabolic Medicine (Y.C.K., B.M., Y.H.N., X.W., Y.H., P.G.B., S.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Charles Perkins Centre (Y.C.K., B.M., Y.H.N., X.W., Y.H., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9841-8189","authenticated-orcid":true,"given":"Yanchuang","family":"Han","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences (Y.C.K., B.M., Y.H.N., X.W., Y.H., S.T., A.Y.B., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Cardiometabolic Medicine (Y.C.K., B.M., Y.H.N., X.W., Y.H., P.G.B., S.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Charles Perkins Centre (Y.C.K., B.M., Y.H.N., X.W., Y.H., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0107-0778","authenticated-orcid":true,"given":"Saki","family":"Tomita","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences (Y.C.K., B.M., Y.H.N., X.W., Y.H., S.T., A.Y.B., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1117-3735","authenticated-orcid":true,"given":"Angela Yu","family":"Bai","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences (Y.C.K., B.M., Y.H.N., X.W., Y.H., S.T., A.Y.B., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6100-9760","authenticated-orcid":true,"given":"Benjamin","family":"Hunter","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences (Y.C.K., B.M., Y.H.N., X.W., Y.H., S.T., A.Y.B., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Charles Perkins Centre (Y.C.K., B.M., Y.H.N., X.W., Y.H., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Precision Cardiovascular Laboratory (B.H., S.L.), The University of Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8901-4788","authenticated-orcid":true,"given":"Ashish","family":"Misra","sequence":"additional","affiliation":[{"name":"Heart Research Institute (A.M.), The University of Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1297-9159","authenticated-orcid":true,"given":"Christopher M.","family":"Loughrey","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Health and School of Biodiversity, One Health and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, United Kingdom (C.M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3117-7250","authenticated-orcid":true,"given":"Paul G.","family":"Bannon","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences (Y.C.K., B.M., Y.H.N., X.W., Y.H., S.T., A.Y.B., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Cardiometabolic Medicine (Y.C.K., B.M., Y.H.N., X.W., Y.H., P.G.B., S.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Charles Perkins Centre (Y.C.K., B.M., Y.H.N., X.W., Y.H., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Department of Cardiothoracic Surgery (P.G.B., J.F.O.), Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia."},{"name":"The Baird Institute for Applied Heart and Lung Surgical Research, Sydney, New South Wales, Australia (P.G.B., S.L., J.F.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5841-560X","authenticated-orcid":true,"given":"Sean","family":"Lal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences (Y.C.K., B.M., Y.H.N., X.W., Y.H., S.T., A.Y.B., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Cardiometabolic Medicine (Y.C.K., B.M., Y.H.N., X.W., Y.H., P.G.B., S.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Charles Perkins Centre (Y.C.K., B.M., Y.H.N., X.W., Y.H., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Precision Cardiovascular Laboratory (B.H., S.L.), The University of Sydney, New South Wales, Australia."},{"name":"Department of Cardiology (S.L., J.F.O.), Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia."},{"name":"The Baird Institute for Applied Heart and Lung Surgical Research, Sydney, New South Wales, Australia (P.G.B., S.L., J.F.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9013-0228","authenticated-orcid":true,"given":"Aldons J.","family":"Lusis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Microbiology and Human Genetics, University of California, Los Angeles (A.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4058-0372","authenticated-orcid":true,"given":"David M.","family":"Kaye","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.M.K.)."},{"name":"Heart Failure Group, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia (D.M.K.)."},{"name":"Faculty of Medicine, Nursing, and Health Sciences, Central Clinical School, Monash University, Melbourne, Victoria, Australia (D.M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8579-2267","authenticated-orcid":true,"given":"Mark","family":"Larance","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences (Y.C.K., B.M., Y.H.N., X.W., Y.H., S.T., A.Y.B., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Charles Perkins Centre (Y.C.K., B.M., Y.H.N., X.W., Y.H., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8016-5128","authenticated-orcid":true,"given":"John F.","family":"O\u2019Sullivan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences (Y.C.K., B.M., Y.H.N., X.W., Y.H., S.T., A.Y.B., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Cardiometabolic Medicine (Y.C.K., B.M., Y.H.N., X.W., Y.H., P.G.B., S.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Charles Perkins Centre (Y.C.K., B.M., Y.H.N., X.W., Y.H., B.H., P.G.B., S.L., M.L., J.F.O.), The University of Sydney, New South Wales, Australia."},{"name":"Department of Cardiothoracic Surgery (P.G.B., J.F.O.), Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia."},{"name":"Department of Cardiology (S.L., J.F.O.), Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia."},{"name":"The Baird Institute for Applied Heart and Lung Surgical Research, Sydney, New South Wales, Australia (P.G.B., S.L., J.F.O.)."},{"name":"Faculty of Medicine, Technische Universit\u00e4t Dresden, Germany (J.F.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29885"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.702795"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0330"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2003.09.007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.9.8.7768357"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-00310-6"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036459"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-00288-1"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.317933"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI156309"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.11.003"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abd7064"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.317046"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.930701"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004750"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.969071"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1601507"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.003862"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1100-z"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.048"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201600135"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.9b00090"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1139\/o59-099"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa051"},{"key":"e_1_3_3_27_2","unstructured":"Kiyonami R Peake DA Liu X Huang Y. Large-scale lipid profiling of a human serum lipidome using a high-resolution accurate-mass LC\/MS\/MS approach. Paper\/Poster presented at: LIPID MAPS Annual Meeting 2015. https:\/\/api.semanticscholar.org\/CorpusID:35040241"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12121272"},{"key":"e_1_3_3_29_2","unstructured":"Peake DA Kiyonami R Yokoi Y Fukamachi Y Huang Y. Processing of a complex lipid dataset for the NIST inter-laboratory comparison exercise for lipidomics measurements in human serum and plasma. Paper\/Poster presented at: ASMS Annual Meeting Saint Louis MO 31st May\u20134th June 2015; 2015."},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.100651"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.2741\/1216"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2019.07.009"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.01.023"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.96.7.2190"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.05.012"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00022.2011"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.3109\/13813457809055968"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.12.022"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1237-6_18"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.192369"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00788500"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.281.6.E1205"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20021617"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02424552"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvae006"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-255901"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST20140135"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2015.02.003"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu059"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)81320-0"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1990.258.3.E519"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04469-z"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2016.11.012"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cophys.2018.03.011"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39162"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq250"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-015-0493-6"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc8861"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.118.004953"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-00296-1"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00068"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2017.10.006"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-015-0182-6"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1513843112"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004257"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.lab.0000074892.53211.a5"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1385\/cp:1:3-4:285"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.3465"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1511"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.031591"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900177R"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)41601-3"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-3247-5_3"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2016.06.007"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2022.05.012"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells11060963"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4304916"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.124.325550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T14:00:34Z","timestamp":1746712834000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.124.325550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,9]]},"references-count":77,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,5,9]]}},"alternative-id":["10.1161\/CIRCRESAHA.124.325550"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.124.325550","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,9]]},"assertion":[{"value":"2024-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-20","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}