{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:56:30Z","timestamp":1793087790577,"version":"4.5.0"},"reference-count":102,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2026,1,16]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Stroke remains a leading cause of mortality and disability, driven by complex, time-dependent mechanisms that aggravate ischemic injury. Collateral perfusion dictates infarct size, expansion rate, and penumbral preservation, yet its regulation is poorly understood. Beyond structural\/genetic factors such as aging or cardiovascular risk, functional influences like circadian immune activity may also affect vascular patency. Neutrophils, key mediators of ischemic injury, exhibit circadian oscillations in phenotype and function that could modulate collateral flow and stroke outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      We combined permanent and transient middle cerebral artery occlusion models in mice with flow cytometry, single-cell RNA sequencing, confocal microscopy, and laser speckle imaging to investigate time-of-day\u2013dependent neutrophil mechanisms in stroke. Pharmacological (chloramidine, DNase-I) and genetic (Pad4 [peptidyl arginine deiminase 4]\n                      <jats:sup>\u2212\/<\/jats:sup>\n                      <jats:sup>\u2212<\/jats:sup>\n                      , Bmal1 [brain and muscle ARNT (aryl hydrocarbon receptor nuclear translocator)-like 1]\n                      <jats:sup>Neu<\/jats:sup>\n                      , Cxcr4 [C-X-C chemokine receptor type 4]\n                      <jats:sup>Neu<\/jats:sup>\n                      ) interventions were used to define how time-of-day regulation shapes neutrophil function, neutrophil extracellular traps (NETs) formation, and stroke severity. A cohort of 540 patients with ischemic stroke was analyzed for diurnal patterns of NET-related biomarkers and their association with collateral circulation and clinical outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Infarct volume and neurological deficits exhibited clear circadian oscillations, with worse outcomes when stroke occurred during the murine inactive phase (Zeitgeber time 5) versus the active phase (Zeitgeber time 13). These fluctuations disappeared after neutrophil depletion or clock disruption. During the inactive phase, neutrophils displayed an activated, NET-prone phenotype, causing microvascular stalling and reduced collateral perfusion. Inhibiting NET formation pharmacologically or through Pad4 deletion restored perfusion and abolished time-of-day effects. In patients, neutrophil and NET-related biomarkers (MPO [myeloperoxidase], elastase, sCD40L [soluble CD40 ligand]) showed diurnal oscillations, peaking during the human inactive phase (evening\/night), coinciding with reduced collateral flow and poorer outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Time-of-day regulation of neutrophil function critically determines collateral perfusion and stroke severity. Neutrophil-driven NETosis during the inactive phase promotes microvascular obstruction and worsens outcomes. Targeting NET formation or timing therapy could enhance collateral efficacy and offer novel chronotherapeutic opportunities for stroke treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circresaha.125.326438","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:00:14Z","timestamp":1764151214000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Circadian Control of Neutrophils Drives Collateral Perfusion and Stroke Outcome"],"prefix":"10.1161","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7365-975X","authenticated-orcid":true,"given":"Sandra","family":"V\u00e1zquez-Reyes","sequence":"first","affiliation":[{"name":"Cardiovascular Risk Factors and Brain Function Programme (S.V.-R., A.G.-C., F.J.D.C.-M., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.R.-P., A.A.-C., I.B., M.I.C., M.A.M.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."},{"name":"Unidad de Investigaci\u00f3n Neurovascular, Departamento de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, (S.V.-R., A.G.-C., G.D., F.J.D.C.-M., B.D.-B., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.M., M.I.C., I.L., M.A.M.), Universidad Complutense de Madrid (UCM), Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2362-0117","authenticated-orcid":true,"given":"Alicia","family":"Garc\u00eda-Culebras","sequence":"additional","affiliation":[{"name":"Cardiovascular Risk Factors and Brain Function Programme (S.V.-R., A.G.-C., F.J.D.C.-M., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.R.-P., A.A.-C., I.B., M.I.C., M.A.M.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."},{"name":"Unidad de Investigaci\u00f3n Neurovascular, Departamento de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, (S.V.-R., A.G.-C., G.D., F.J.D.C.-M., B.D.-B., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.M., M.I.C., I.L., M.A.M.), Universidad Complutense de Madrid (UCM), Spain."},{"name":"Departamento de Biolog\u00eda Celular e Histolog\u00eda, Facultad de Medicina (A.G.-C., A.M.), Universidad Complutense de Madrid (UCM), Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaohong","family":"Di","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Neurovascular, Departamento de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, (S.V.-R., A.G.-C., G.D., F.J.D.C.-M., B.D.-B., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.M., M.I.C., I.L., M.A.M.), Universidad Complutense de Madrid (UCM), Spain."},{"name":"Now with Anesthesiology Department, Sixth Hospital Wuhan, Jianghan University, China (G.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"De Castro-Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Cardiovascular Risk Factors and Brain Function Programme (S.V.-R., A.G.-C., F.J.D.C.-M., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.R.-P., A.A.-C., I.B., M.I.C., M.A.M.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."},{"name":"Unidad de Investigaci\u00f3n Neurovascular, Departamento de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, (S.V.-R., A.G.-C., G.D., F.J.D.C.-M., B.D.-B., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.M., M.I.C., I.L., M.A.M.), Universidad Complutense de Madrid (UCM), Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9491-0616","authenticated-orcid":true,"given":"Blanca","family":"D\u00edaz-Benito","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Neurovascular, Departamento de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, (S.V.-R., A.G.-C., G.D., F.J.D.C.-M., B.D.-B., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.M., M.I.C., I.L., M.A.M.), Universidad Complutense de Madrid (UCM), Spain."},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12, i+12), Madrid, Spain (B.D.-B., A.M., P.C., I.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1653-9943","authenticated-orcid":true,"given":"Carmen","family":"Nieto-Vaquero","sequence":"additional","affiliation":[{"name":"Cardiovascular Risk Factors and Brain Function Programme (S.V.-R., A.G.-C., F.J.D.C.-M., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.R.-P., A.A.-C., I.B., M.I.C., M.A.M.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."},{"name":"Unidad de Investigaci\u00f3n Neurovascular, Departamento de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, (S.V.-R., A.G.-C., G.D., F.J.D.C.-M., B.D.-B., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.M., M.I.C., I.L., M.A.M.), Universidad Complutense de Madrid (UCM), Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4867-690X","authenticated-orcid":true,"given":"Alessandra","family":"Ruiz-Sanchez","sequence":"additional","affiliation":[{"name":"Cardiovascular Risk Factors and Brain Function Programme (S.V.-R., A.G.-C., F.J.D.C.-M., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.R.-P., A.A.-C., I.B., M.I.C., M.A.M.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."},{"name":"Unidad de Investigaci\u00f3n Neurovascular, Departamento de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, (S.V.-R., A.G.-C., G.D., F.J.D.C.-M., B.D.-B., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.M., M.I.C., I.L., M.A.M.), Universidad Complutense de Madrid (UCM), Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8629-9949","authenticated-orcid":true,"given":"Eneko","family":"Merino-Casamayor","sequence":"additional","affiliation":[{"name":"Cardiovascular Risk Factors and Brain Function Programme (S.V.-R., A.G.-C., F.J.D.C.-M., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.R.-P., A.A.-C., I.B., M.I.C., M.A.M.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."},{"name":"Unidad de Investigaci\u00f3n Neurovascular, Departamento de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, (S.V.-R., A.G.-C., G.D., F.J.D.C.-M., B.D.-B., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.M., M.I.C., I.L., M.A.M.), Universidad Complutense de Madrid (UCM), Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3817-1445","authenticated-orcid":true,"given":"Carlos","family":"Parra-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Cardiovascular Risk Factors and Brain Function Programme (S.V.-R., A.G.-C., F.J.D.C.-M., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.R.-P., A.A.-C., I.B., M.I.C., M.A.M.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."},{"name":"Unidad de Investigaci\u00f3n Neurovascular, Departamento de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, (S.V.-R., A.G.-C., G.D., F.J.D.C.-M., B.D.-B., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.M., M.I.C., I.L., M.A.M.), Universidad Complutense de Madrid (UCM), Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6695-557X","authenticated-orcid":true,"given":"Ana","family":"Moraga","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Neurovascular, Departamento de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, (S.V.-R., A.G.-C., G.D., F.J.D.C.-M., B.D.-B., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.M., M.I.C., I.L., M.A.M.), Universidad Complutense de Madrid (UCM), Spain."},{"name":"Departamento de Biolog\u00eda Celular e Histolog\u00eda, Facultad de Medicina (A.G.-C., A.M.), Universidad Complutense de Madrid (UCM), Spain."},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12, i+12), Madrid, Spain (B.D.-B., A.M., P.C., I.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Core-Barrera","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Universitario El Escorial, Madrid, Spain (C.C.-B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4858-1927","authenticated-orcid":true,"given":"Patricia","family":"Calleja","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12, i+12), Madrid, Spain (B.D.-B., A.M., P.C., I.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4910-1684","authenticated-orcid":true,"given":"Ana","family":"Dopazo","sequence":"additional","affiliation":[{"name":"Genomics Unit (A.D., S.C.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."},{"name":"CIBER de Enfermedades Cardiovasculares, Madrid, Spain (A.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3351-4940","authenticated-orcid":true,"given":"Sergio","family":"Callejas","sequence":"additional","affiliation":[{"name":"Genomics Unit (A.D., S.C.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4275-8835","authenticated-orcid":true,"given":"Andrea","family":"Rubio-Ponce","sequence":"additional","affiliation":[{"name":"Cardiovascular Risk Factors and Brain Function Programme (S.V.-R., A.G.-C., F.J.D.C.-M., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.R.-P., A.A.-C., I.B., M.I.C., M.A.M.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2481-0863","authenticated-orcid":true,"given":"Alejandra","family":"Aroca-Crevill\u00e9n","sequence":"additional","affiliation":[{"name":"Cardiovascular Risk Factors and Brain Function Programme (S.V.-R., A.G.-C., F.J.D.C.-M., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.R.-P., A.A.-C., I.B., M.I.C., M.A.M.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."},{"name":"Cardiovascular Regeneration Programme (A.A.-C., A.H.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1881-1664","authenticated-orcid":true,"given":"F\u00e1tima","family":"S\u00e1nchez-Cabo","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit (F.S.-C., S.P.E.B., C.T.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1938-3236","authenticated-orcid":true,"given":"Sara","family":"Pascual El Bobakry","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit (F.S.-C., S.P.E.B., C.T.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8914-3400","authenticated-orcid":true,"given":"Carlos","family":"Torroja","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit (F.S.-C., S.P.E.B., C.T.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8287-2747","authenticated-orcid":true,"given":"Elga","family":"Esposito","sequence":"additional","affiliation":[{"name":"Radiology Department, Massachusetts General Hospital, Harvard Medical School, Boston (E.E., E.H.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9327-2915","authenticated-orcid":true,"given":"Eng H.","family":"Lo","sequence":"additional","affiliation":[{"name":"Radiology Department, Massachusetts General Hospital, Harvard Medical School, Boston (E.E., E.H.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Ballesteros","sequence":"additional","affiliation":[{"name":"Cardiovascular Risk Factors and Brain Function Programme (S.V.-R., A.G.-C., F.J.D.C.-M., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.R.-P., A.A.-C., I.B., M.I.C., M.A.M.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."},{"name":"Department of Neuroscience and Biomedical Sciences, Universidad Carlos III de Madrid, Spain (I.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5513-555X","authenticated-orcid":true,"given":"Andr\u00e9s","family":"Hidalgo","sequence":"additional","affiliation":[{"name":"Cardiovascular Regeneration Programme (A.A.-C., A.H.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."},{"name":"Vascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, CT (A.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4728-068X","authenticated-orcid":true,"given":"Mar\u00eda Isabel","family":"Cuartero","sequence":"additional","affiliation":[{"name":"Cardiovascular Risk Factors and Brain Function Programme (S.V.-R., A.G.-C., F.J.D.C.-M., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.R.-P., A.A.-C., I.B., M.I.C., M.A.M.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."},{"name":"Unidad de Investigaci\u00f3n Neurovascular, Departamento de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, (S.V.-R., A.G.-C., G.D., F.J.D.C.-M., B.D.-B., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.M., M.I.C., I.L., M.A.M.), Universidad Complutense de Madrid (UCM), Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6028-7379","authenticated-orcid":true,"given":"Ignacio","family":"Lizasoain","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Neurovascular, Departamento de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, (S.V.-R., A.G.-C., G.D., F.J.D.C.-M., B.D.-B., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.M., M.I.C., I.L., M.A.M.), Universidad Complutense de Madrid (UCM), Spain."},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12, i+12), Madrid, Spain (B.D.-B., A.M., P.C., I.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-8237","authenticated-orcid":true,"given":"Mar\u00eda \u00c1ngeles","family":"Moro","sequence":"additional","affiliation":[{"name":"Cardiovascular Risk Factors and Brain Function Programme (S.V.-R., A.G.-C., F.J.D.C.-M., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.R.-P., A.A.-C., I.B., M.I.C., M.A.M.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain."},{"name":"Unidad de Investigaci\u00f3n Neurovascular, Departamento de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Medicina, (S.V.-R., A.G.-C., G.D., F.J.D.C.-M., B.D.-B., C.N.-V., A.R.-S., E.M.-C., C.P.-P., A.M., M.I.C., I.L., M.A.M.), Universidad Complutense de Madrid (UCM), Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20741"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031742"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.124.323508"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2348-z"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.040547"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.01.002"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103124"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2024.114796"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-023-01226-5"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.04.040"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0571-2"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-08-868067"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01614-8"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00302"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0326-7"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.026848"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci154225"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108260"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-051222-015009"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002470"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025085"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01505-1"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01711-x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjos-2020-100115"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06685"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3386"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15367"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041185"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10649"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.10.010"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130056"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3322"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201506083"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.10.007"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1381-0"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1355-2"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193970"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.45"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00183.2018"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118392"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1994.137"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.22.10.1276"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.23.5.712"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256478"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060925"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2156"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.10.008"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.12.001"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209038"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1785"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19412-6"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.11.055"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13525"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3133"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00491-3"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.150"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003093"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-0154-9_26"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9092079"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.041394"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.034947"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2020.11.007"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80590"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.313349"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.039932"},{"key":"e_1_3_3_69_2","first-page":"280","article-title":"Preclinical evaluation of circadian rhythm in ischemic stroke outcomes.","volume":"4","author":"Kamat PK","year":"2021","unstructured":"Kamat PK, Khan MB, Wood K, Siddiqui S, Rudic DR, Dhandapani K, Waller J, Hess DC. Preclinical evaluation of circadian rhythm in ischemic stroke outcomes. Cond Med. 2021;4:280\u2013284","journal-title":"Cond Med"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-326072"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003910"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200102000-00014"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.026743"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20914179"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04263-y"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1098-5"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000130592.71028.92"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.10.003"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0141-8"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0736-z"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22973-9"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1769510"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005861"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.321750"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.312463"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16191-y"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009532"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-022-02707-0"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(23)00368-3"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.049961"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181468"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam8897"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.3791\/52031"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI120412"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.101"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.8"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.600452"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.015956"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176770"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw777"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.73600.2"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw377"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.125.326438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:02:04Z","timestamp":1772791324000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.125.326438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,16]]},"references-count":102,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1,16]]}},"alternative-id":["10.1161\/CIRCRESAHA.125.326438"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.125.326438","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,16]]},"assertion":[{"value":"2025-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-28","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}