{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:33:51Z","timestamp":1794011631170,"version":"4.8.0"},"reference-count":102,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2026,1,30]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Pulmonary interstitial macrophages can be divided into 2 distinct subsets with different origins: resident macrophages (resM\u0424s) and recruited macrophages (recM\u0424s). However, their specific roles in pulmonary arterial hypertension remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Bone marrow transplantation, the DT (diphtheria toxin) receptor system, and genetically modified murine models were utilized to explore how key TFs (transcription factors) regulate phenotype alterations in pulmonary resM\u0424s and recM\u0424s in an SU5416\/hypoxia murine model of pulmonary hypertension (PH). Therapeutic approaches included DNA aptamer\u2013based proteolysis-targeting chimera and small interfering RNA\u2013loaded lipid nanoparticle for treating SU5416\/hypoxia\u2013exposed rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Depletion of either resM\u0424s or recM\u0424s using DT treatment significantly reduced SU5416\/hypoxia\u2013induced PH in mice. Pulmonary recM\u0424s exhibited a proinflammatory phenotype during PH, driven by the TF Hic1 (hypermethylated in cancer 1). Bone marrow transplantation with Hic1\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      recM\u0424s ameliorated PH in mice. Hic1 enhanced proinflammatory gene transcription by inhibiting Sirt1 (sirtuin 1)-mediated H3K9ac (histone H3 lysine 9 acetylation) deacetylation in the promoter regions. In contrast, pulmonary resM\u0424s demonstrated a profibrotic transcriptome characterized by upregulation of\n                      <jats:italic toggle=\"yes\">MMP<\/jats:italic>\n                      genes that are, in turn, regulated by Prrx2 (paired-related homeobox 2). Prrx2 deletion in resM\u0424s protected against PH in mice by reducing perivascular fibrosis. Simultaneously targeting\n                      <jats:italic toggle=\"yes\">Prrx2<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Hic1<\/jats:italic>\n                      in macrophages significantly alleviated SU5416\/hypoxia\u2013induced PH in rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      The differential roles of pulmonary resM\u0424s and recM\u0424s in pulmonary vascular remodeling highlight novel therapeutic targets for pulmonary arterial hypertension treatment, specifically through inhibition of\n                      <jats:italic toggle=\"yes\">Hic1<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Prrx2<\/jats:italic>\n                      in macrophages.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circresaha.125.326472","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:00:47Z","timestamp":1767175247000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Differential Impact of Recruited and Resident Macrophages on Hypoxia-Induced Pulmonary Hypertension"],"prefix":"10.1161","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6150-463X","authenticated-orcid":true,"given":"Shumin","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology (S.G., T.P., Y.C., R.D., Q.L., Y. Zhuo, Y. Zhao, D.T., X.S., T.Q., X.C., D.H., Y.S., Y.Y.), School of Basic Medical Sciences, Tianjin Medical University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0694-1905","authenticated-orcid":true,"given":"Ting","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology (S.G., T.P., Y.C., R.D., Q.L., Y. Zhuo, Y. Zhao, D.T., X.S., T.Q., X.C., D.H., Y.S., Y.Y.), School of Basic Medical Sciences, Tianjin Medical University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5257-2148","authenticated-orcid":true,"given":"Xiaojie","family":"Yan","sequence":"additional","affiliation":[{"name":"The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology (X.Y., Y.H., C.D.), School of Basic Medical Sciences, Tianjin Medical University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2707-6760","authenticated-orcid":true,"given":"Yuanyuan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology (S.G., T.P., Y.C., R.D., Q.L., Y. Zhuo, Y. Zhao, D.T., X.S., T.Q., X.C., D.H., Y.S., Y.Y.), School of Basic Medical Sciences, Tianjin Medical University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9327-7073","authenticated-orcid":true,"given":"Ronglu","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology (S.G., T.P., Y.C., R.D., Q.L., Y. Zhuo, Y. Zhao, D.T., X.S., T.Q., X.C., D.H., Y.S., Y.Y.), School of Basic Medical Sciences, Tianjin Medical University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology (S.G., T.P., Y.C., R.D., Q.L., Y. Zhuo, Y. Zhao, D.T., X.S., T.Q., X.C., D.H., Y.S., Y.Y.), School of Basic Medical Sciences, Tianjin Medical University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7369-9769","authenticated-orcid":true,"given":"Yongle","family":"Huang","sequence":"additional","affiliation":[{"name":"The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology (X.Y., Y.H., C.D.), School of Basic Medical Sciences, Tianjin Medical University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology (S.G., T.P., Y.C., R.D., Q.L., Y. Zhuo, Y. Zhao, D.T., X.S., T.Q., X.C., D.H., Y.S., Y.Y.), School of Basic Medical Sciences, Tianjin Medical University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3003-2890","authenticated-orcid":true,"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology (S.G., T.P., Y.C., R.D., Q.L., Y. Zhuo, Y. Zhao, D.T., X.S., T.Q., X.C., D.H., Y.S., Y.Y.), School of Basic Medical Sciences, Tianjin Medical University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology (S.G., T.P., Y.C., R.D., Q.L., Y. Zhuo, Y. Zhao, D.T., X.S., T.Q., X.C., D.H., Y.S., Y.Y.), School of Basic Medical Sciences, Tianjin Medical University, China."},{"name":"Department of Physiology, School of Basic Medical Sciences, Hebei Medical University, Shijiazhuang, China (D.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology (S.G., T.P., Y.C., R.D., Q.L., Y. Zhuo, Y. Zhao, D.T., X.S., T.Q., X.C., D.H., Y.S., Y.Y.), School of Basic Medical Sciences, Tianjin Medical University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titi","family":"Qiang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology (S.G., T.P., Y.C., R.D., Q.L., Y. Zhuo, Y. Zhao, D.T., X.S., T.Q., X.C., D.H., Y.S., Y.Y.), School of Basic Medical Sciences, Tianjin Medical University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology (S.G., T.P., Y.C., R.D., Q.L., Y. Zhuo, Y. Zhao, D.T., X.S., T.Q., X.C., D.H., Y.S., Y.Y.), School of Basic Medical Sciences, Tianjin Medical University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1314-3417","authenticated-orcid":true,"given":"Xiaoqiang","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu (X.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Korinek","sequence":"additional","affiliation":[{"name":"Laboratory of Cell and Developmental Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague (V.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3503-5855","authenticated-orcid":true,"given":"Dandan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology (S.G., T.P., Y.C., R.D., Q.L., Y. Zhuo, Y. Zhao, D.T., X.S., T.Q., X.C., D.H., Y.S., Y.Y.), School of Basic Medical Sciences, Tianjin Medical University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5278-5522","authenticated-orcid":true,"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[{"name":"CAS CEMCS-CUHK Joint Laboratories, New Cornerstone Science Laboratory, State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences (B.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7986-6082","authenticated-orcid":true,"given":"Jiong-Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore (J.-W.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2891-8759","authenticated-orcid":true,"given":"Cheng","family":"Dong","sequence":"additional","affiliation":[{"name":"The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology (X.Y., Y.H., C.D.), School of Basic Medical Sciences, Tianjin Medical University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2653-1307","authenticated-orcid":true,"given":"Yong","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Zhengzhou University People\u2019s Hospital, Henan Provincial People\u2019s Hospital, China (Y.Q.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9266-9064","authenticated-orcid":true,"given":"Yujun","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology (S.G., T.P., Y.C., R.D., Q.L., Y. Zhuo, Y. Zhao, D.T., X.S., T.Q., X.C., D.H., Y.S., Y.Y.), School of Basic Medical Sciences, Tianjin Medical University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6476-1752","authenticated-orcid":true,"given":"Ying","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology (S.G., T.P., Y.C., R.D., Q.L., Y. Zhuo, Y. Zhao, D.T., X.S., T.Q., X.C., D.H., Y.S., Y.Y.), School of Basic Medical Sciences, Tianjin Medical University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/pul2.12137"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.040629"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.933762"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev097"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201809-1631LE"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.14525"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.08.015"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1152881"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI170501"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.08.010"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0182OC"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02308-2018"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.12.001"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202303-0506ED"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2016-0201OC"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.059435"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3005"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0582-z"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35095-7"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03249.x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1084-z"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000073585.50092.14"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601692"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77656"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.11.054"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.011"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2015-0020TR"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01570-2"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50753-8"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249739"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c03852"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-023-01508-3"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6528\/ac2810"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900239"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15494"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701287"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202203-0441OC"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201502-0407OC"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37527-4"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.918636"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0265-3"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-341123"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2016.1"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01257-8"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1177\/09636897221081479"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00417.2009"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000224"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1182030"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03148-w"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.10.010"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200509-1518OC"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01216"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.933187"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2016-0361OC"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.837188"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00014.2012"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0276-y"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202209-1761oc"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2023.108438"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01551-9"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119964109"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-022-00856-w"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-015-2128-5"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.440370"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14914"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108356"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm-22-732"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01668-1"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00007314"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02044-2014"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15036"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1430350"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-024-02772-8"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00199-0"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-024-00977-6"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-3465"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00898-0"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq408"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-568691"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21619-0"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-14496-z"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4437"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20719"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151794"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316784"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171767"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201911-2137OC"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.145811"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202400338RR"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3655"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202203-0450OC"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001585"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.55571"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1039\/c8nr09417a"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-584-7:531"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1045"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909047337"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889807021206"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904019158"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1107\/s0907444902016657"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c10972"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.321041"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.125.326472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T19:00:23Z","timestamp":1769713223000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.125.326472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":102,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,1,30]]}},"alternative-id":["10.1161\/CIRCRESAHA.125.326472"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.125.326472","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"assertion":[{"value":"2025-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}