{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:14:16Z","timestamp":1793297656805,"version":"4.5.0"},"reference-count":70,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2026,6,19]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Vascular smooth muscle cells (VSMCs) play a central role in atherosclerosis by undergoing phenotypic modulation from a quiescent, contractile state to a range of synthetic phenotypes, including fibroblast-like, macrophage-like, and lipid-laden foam cell\u2013like states. However, a comprehensive multimodal characterization and understanding of the transcriptional programs driving these transitions remain incomplete.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>To comprehensively define the phenotypic diversity of VSMCs during atherosclerosis progression, we performed in-depth profiling using cellular indexing of transcriptomes and epitopes by sequencing and bulk RNA sequencing in a VSMC-lineage\u2013tracing atherosclerotic mouse model. Insights from these data sets guided the design of targeted in vitro experiments to investigate candidate regulatory mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Single-cell multiomics revealed extensive cellular heterogeneity within atherosclerotic plaques, including a rare population of VSMC-derived macrophage-like cells, whose presence was confirmed by histological analysis. These studies also identified a large population of VSMC-derived foam cells that exhibited activation of gene programs associated with lipid metabolism, proliferation, and tumor-like features. The transcription factor BHLHE40 (basic helix-loop-helix family member e40) emerged as a candidate regulator of this phenotypic transition, with elevated expression and activity in VSMC-derived foam cells during disease progression and expression in modulated VSMC in human carotid atherosclerosis. Functional knockdown of\n                      <jats:italic toggle=\"yes\">Bhlhe40<\/jats:italic>\n                      reprogrammed immune, cell cycle, and lipid homeostasis genes in cultured VSMC and suppressed VSMC phenotypic switching and foam cell characteristics, consistent with a potential regulatory role in VSMC modulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>These findings advance our understanding of VSMC phenotypic modulation in atherosclerosis and implicate BHLHE40 as a candidate transcriptional regulator of this process. Elucidating mechanisms governing VSMC plasticity may offer new therapeutic opportunities to reduce cardiovascular risk by targeting disease-driving cellular transitions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circresaha.125.326821","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:08:53Z","timestamp":1778663333000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Atherosclerosis Profiling Reveals BHLHE40 as a Candidate Modulator of VSMC"],"prefix":"10.1161","volume":"139","author":[{"given":"Chinyere O.","family":"Ibikunle","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.)."},{"name":"Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.), Columbia University Irving Medical Center, New York, NY."},{"name":"Department of Biological Sciences, Columbia University, New York, NY (C.O.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4779-5766","authenticated-orcid":true,"given":"Enrique J.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.)."},{"name":"Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.), Columbia University Irving Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8829-7659","authenticated-orcid":true,"given":"Chenyi","family":"Xue","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.)."},{"name":"Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.), Columbia University Irving Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9749-9930","authenticated-orcid":true,"given":"Eunyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.)."},{"name":"Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.), Columbia University Irving Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9227-1742","authenticated-orcid":true,"given":"Hanying","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia (H.Y., M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9257-0849","authenticated-orcid":true,"given":"Johana","family":"Coronel","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.)."},{"name":"Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.), Columbia University Irving Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1048-5377","authenticated-orcid":true,"given":"Lucie Y.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.)."},{"name":"Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.), Columbia University Irving Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Cui","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.)."},{"name":"Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.), Columbia University Irving Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2494-9179","authenticated-orcid":true,"given":"Allen","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.)."},{"name":"Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.), Columbia University Irving Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3148-440X","authenticated-orcid":true,"given":"Lauren E.","family":"Fries","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.)."},{"name":"Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.), Columbia University Irving Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8031-017X","authenticated-orcid":true,"given":"Nadja","family":"Sachs","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Technical University Munich (TUM) University Hospital Klinikum, TUM, Germany (N.S.)."},{"name":"German Center for Cardiovascular Research, Partner Site Munich Heart Alliance (N.S., L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9752-9645","authenticated-orcid":true,"given":"Robert C.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.)."},{"name":"Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.), Columbia University Irving Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5228-2634","authenticated-orcid":true,"given":"Lars","family":"Maegdefessel","sequence":"additional","affiliation":[{"name":"Institute of Molecular Vascular Medicine, TUM Klinikum, TUM, Germany (L.M.)."},{"name":"German Center for Cardiovascular Research, Partner Site Munich Heart Alliance (N.S., L.M.)."},{"name":"Department of Medicine, Karolinska Institute, Stockholm, Sweden (L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2422-9494","authenticated-orcid":true,"given":"Mingyao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia (H.Y., M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7708-2417","authenticated-orcid":true,"given":"Alan R.","family":"Tall","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Department of Medicine (A.R.T.), Columbia University Irving Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1380-9242","authenticated-orcid":true,"given":"Alexander C.","family":"Bashore","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.)."},{"name":"Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.), Columbia University Irving Medical Center, New York, NY."},{"name":"Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY (A.C.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3035-9386","authenticated-orcid":true,"given":"Muredach P.","family":"Reilly","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.)."},{"name":"Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.), Columbia University Irving Medical Center, New York, NY."},{"name":"Irving Institute for Clinical and Translational Research (M.P.R.), Columbia University Irving Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043430"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3866"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2003"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306361"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-012110-142315"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2004.03.004"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs115"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0512-5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.046672"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.048378"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.304634"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.067092"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.123.320524"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.20900\/immunometab20210022"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.123.320030"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.067587"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113380"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316903"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.18.8529"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.312434"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005015"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.316063"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw216"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1735526100"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.315164"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.24.9542"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-022-00042-8"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.057789"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-00338-8"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.320047"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2020.09.002"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100944R"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2023.100411"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36826"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","unstructured":"Kiss Z Mudryj M Ghosh PM. Non-circadian aspects of BHLHE40 cellular function in cancer. Genes Cancer. 2020;11:1\u201319. doi: 10.18632\/genesandcancer.201","DOI":"10.18632\/genesandcancer.201"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46315-7"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4380"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1382-0"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-021-02577-8"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-4772-0"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","unstructured":"Vlahos L Obradovic A Worley J Tan X Howe A Laise P Wang A Drake CG Califano A. Systematic protein activity-based characterization of single cell state. bioRxiv. Preprint posted online January 10 2023. doi: 10.1101\/2021.05.20.445002","DOI":"10.1101\/2021.05.20.445002"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.3390\/e25030542"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05688-9"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4197"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7563.2"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3519"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty895"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","unstructured":"Korotkevich G Sukhov V Budin N Shpak B Artyomov MN Sergushichev A. Fast gene set enrichment analysis. bioRxiv. Preprint posted online February 1 2021. doi: 10.1101\/060012","DOI":"10.1101\/060012"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","unstructured":"Liberzon A Birger C Thorvaldsd\u00f3ttir H Ghandi M Mesirov J Tamayo P. The Molecular Signatures Database (MSigDB) hallmark gene set collection. Cell Syst. 2015;1:417\u2013 425. doi: 10.1016\/j.cels.2015.12.004","DOI":"10.1016\/j.cels.2015.12.004"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaf1292"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad1025"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8020251"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-85"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-016-0809-y"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2011-4147"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7558-7_19"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2009.04.008"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2025.105969"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.01.060"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2011.01675.x"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6939"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0258(20000515)19:9<1141::aid-sim479>3.0.co;2-f"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v082.i13"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","unstructured":"Lenth RV Piaskowski J. emmeans: Estimated Marginal Means aka least-squares means. R Package Version 202. CRAN: Contributed Packages. 2017. doi: 10.32614\/cran.package.emmeans","DOI":"10.32614\/cran.package.emmeans"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.125.326821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:00:25Z","timestamp":1789063225000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.125.326821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,6,19]]}},"alternative-id":["10.1161\/CIRCRESAHA.125.326821"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.125.326821","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,19]]},"assertion":[{"value":"2025-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}