{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:49:47Z","timestamp":1790819387806,"version":"4.1.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2026,5,22]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Micro(nano)plastics (MNPs) are pervasive environmental contaminants, yet their presence in human cardiac tissue and their potential contribution to myocardial fibrosis remain unclear. We investigated whether myocardial MNP burden is associated with fibrosis severity in patients and evaluated mechanistic plausibility in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Left atrial appendage tissues were collected from patients undergoing cardiac surgery (n=33). MNP burden and polymer composition were quantified by pyrolysis-gas chromatography\/mass spectrometry, and fibrosis was quantified histologically. In mice, 100-nm or 1-\u00b5m polystyrene nanoplastics were administered by oral gavage in coexposure and sequential exposure protocols with isoprenaline. Cardiac function was assessed by echocardiography, and fibrosis was evaluated by histology and immunohistochemistry. Transcriptomics, metabolomics, and 16S ribosomal RNA sequencing were performed to identify pathways linked to MNP exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      MNPs were detected in all human cardiac samples. Patients with high fibrosis exhibited higher total MNP levels than those with low fibrosis (171.74 [interquartile range [IQR], 158.18\u2013202.39] versus 119.33 [IQR, 102.75\u2013148.44] \u00b5g\/g tissue;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =2.5\u00d710\n                      <jats:sup>\u2013<\/jats:sup>\n                      <jats:sup>4<\/jats:sup>\n                      ), driven predominantly by elevated nanoplastics (122.83 [IQR, 100.10\u2013149.06] versus 86.39 [IQR, 36.85\u2013103.74] \u00b5g\/g;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.010). Polystyrene and polyvinyl chloride were enriched in high-fibrosis tissues (polystyrene:\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =3.3\u00d710\n                      <jats:sup>\u2013<\/jats:sup>\n                      <jats:sup>4<\/jats:sup>\n                      ; polyvinyl chloride:\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.002). Transcriptomics indicated activation of inflammatory and profibrotic pathways (TNF [tumor necrosis factor]\/NF-\u03baB [nuclear factor-\u03baB], TGF-\u03b2 [transforming growth factor-beta], and MAPK [mitogen-activated protein kinase]), supported by increased \u03b1-SMA (alpha-smooth muscle actin), COL1 (collagen I), and TGF-\u03b21 immunostaining, while metabolomics suggested perturbations in lipid metabolism and mitochondrial function. In mice, polystyrene exposure exacerbated isoprenaline-induced systolic dysfunction and myocardial fibrosis in both experimental paradigms and recapitulated pathway signatures related to cell-matrix interactions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Myocardial MNP burden, particularly nanoplastics, is associated with greater fibrosis in humans, and experimental polystyrene exposure aggravates stress-induced myocardial remodeling in vivo. Multiomics analyses nominate inflammatory, ECM (extracellular matrix), and metabolic programs as candidate mediators of MNP-associated cardiotoxicity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circresaha.125.327073","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:00:20Z","timestamp":1777280420000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Micro(nano)plastics in the Development of Myocardial Fibrosis: From Clinical Detection to Molecular Mechanism"],"prefix":"10.1161","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5677-6399","authenticated-orcid":true,"given":"Yilin","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery (Y.P., J. Luo, X.Z., L.Z., Z.P., G.S., K.H., X.Y.), Beijing Anzhen Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6525-1531","authenticated-orcid":true,"given":"Linqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology (L.L., Y.Y.), Beijing Anzhen Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery (Y.P., J. Luo, X.Z., L.Z., Z.P., G.S., K.H., X.Y.), Beijing Anzhen Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery (Y.P., J. Luo, X.Z., L.Z., Z.P., G.S., K.H., X.Y.), Beijing Anzhen Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Cardiovascular Diseases (Y.W.), Beijing Anzhen Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery (Y.P., J. Luo, X.Z., L.Z., Z.P., G.S., K.H., X.Y.), Beijing Anzhen Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7921-2484","authenticated-orcid":true,"given":"Yunxiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology (L.L., Y.Y.), Beijing Anzhen Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4621-1968","authenticated-orcid":true,"given":"Zhan","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery (Y.P., J. Luo, X.Z., L.Z., Z.P., G.S., K.H., X.Y.), Beijing Anzhen Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5924-4392","authenticated-orcid":true,"given":"Jiawei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Nursing (J. Li), Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanming","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery (Y.P., J. Luo, X.Z., L.Z., Z.P., G.S., K.H., X.Y.), Beijing Anzhen Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6023-2618","authenticated-orcid":true,"given":"Mianqi","family":"Xue","sequence":"additional","affiliation":[{"name":"Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China (M.X.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery (Y.P., J. Luo, X.Z., L.Z., Z.P., G.S., K.H., X.Y.), Beijing Anzhen Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5442-2071","authenticated-orcid":true,"given":"Hanqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Environment and Aging, School of Public Health (H.C.), Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4237-7450","authenticated-orcid":true,"given":"Xiubin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery (Y.P., J. 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