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However, early development programs of pharmacological CETP inhibitors proved disappointing with evidence of off-target toxicity, clinical futility, or marginal cardiovascular benefit with adipose tissue accumulation. Subsequent investigation of these programs and genomic studies has identified a pathway for drug development, in which promoting the ability of CETP inhibitors to lower levels of atherogenic lipids and lipoproteins and exerting a favorable impact on glycemic control may translate to reductions in cardiovascular risk, as opposed to the original motivation to raise HDL (high-density lipoprotein) cholesterol levels. Obicetrapib is a highly selective CETP inhibitor with evidence of favorable effects on atherogenic lipids and lipoproteins, glycemic control, and biomarkers of beta-amyloid pathology in preclinical Alzheimer disease. 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