{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:29:01Z","timestamp":1788834541800,"version":"build-2803163510"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2026,1,16]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Myocardial infarction (MI) is a leading cause of death worldwide and can eliminate up to a third of the cardiomyocytes within the human heart. Although cardiomyocytes undergo mitosis during early development, most cardiomyocytes cease cell cycling soon after birth. In contrast, rodent MI models have shown that cardiomyocytes increase mitosis in response to ischemia; however, this has not been shown in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Using a unique premortem post-MI human heart, immunostaining, bulk RNA sequencing, proteomics, metabolomics, single-nucleus RNA sequencing and a novel post-MI human biopsy method, we investigated human cardiomyocyte mitosis post-MI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>We show that adult human cardiomyocytes exhibit increased mitosis and cytokinesis in response to ischemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Future development of therapeutics to enhance this intrinsic mitotic potential could lead to new treatments that reverse heart failure via cardiac regeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circresaha.125.327486","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T10:00:39Z","timestamp":1764842439000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Human Hearts Intrinsically Increase Cardiomyocyte Mitosis After Myocardial Infarction"],"prefix":"10.1161","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3694-9333","authenticated-orcid":true,"given":"Robert D.","family":"Hume","sequence":"first","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health (R.D.H., J.W., C.M., L.S., D.H., E.S., X.W., L.N., L.C., A.L.F., M.L., S.L.), University of Sydney, Sydney, New South Wales, Australia."},{"name":"The Charles Perkins Centre (R.D.H., J.W., C.M., L.S., D.H., A.L.F., M.L., J.F.O., P.B., S.L.), University of Sydney, Sydney, New South Wales, Australia."},{"name":"Centre for Heart Failure and Diseases of the Aorta, The Baird Institute, Sydney, New South Wales, Australia (R.D.H., C.M., L.S., J.F.O., P.B., S.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2519-5767","authenticated-orcid":true,"given":"Jessica","family":"Warwick","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health (R.D.H., J.W., C.M., L.S., D.H., E.S., X.W., L.N., L.C., A.L.F., M.L., S.L.), University of Sydney, Sydney, New South Wales, Australia."},{"name":"The Charles Perkins Centre (R.D.H., J.W., C.M., L.S., D.H., A.L.F., M.L., J.F.O., P.B., S.L.), University of Sydney, Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9446-7821","authenticated-orcid":true,"given":"Woo Jun","family":"Shim","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia (W.J.S., N.J.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra","family":"Malecki","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health (R.D.H., J.W., C.M., L.S., D.H., E.S., X.W., L.N., L.C., A.L.F., M.L., S.L.), University of Sydney, Sydney, New South Wales, Australia."},{"name":"The Charles Perkins Centre (R.D.H., J.W., C.M., L.S., D.H., A.L.F., M.L., J.F.O., P.B., S.L.), University of Sydney, Sydney, New South Wales, Australia."},{"name":"Centre for Heart Failure and Diseases of the Aorta, The Baird Institute, Sydney, New South Wales, Australia (R.D.H., C.M., L.S., J.F.O., P.B., S.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9666-5810","authenticated-orcid":true,"given":"Mengbo","family":"Li","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia (M. 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