{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:24:26Z","timestamp":1787855066032,"version":"build-2784847793"},"reference-count":98,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2026,8,28]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Intracranial aneurysms (IAs) are localized dilations of cerebral arteries that pose a significant threat of rupture, leading to fatal subarachnoid hemorrhage. The inflammation driven by immune cell infiltration is believed to be a key driver for the pathogenesis of IAs; however, the detailed immune cell landscape and spatial composition of immune cells remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>In this study, we employed an integrated multi-omics approach using human IA tissues, including single\u2011cell RNA sequencing, spatial transcriptomics, microarray data, and multiplex immunofluorescence, to construct a comprehensive immune cell atlas of IAs, providing a systematic characterization of their immune composition and spatial architecture. Findings were further validated in a mouse model of IA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>We identified, for the first time, tertiary lymphoid structures within the aneurysm wall and demonstrated that their presence strongly correlates with rupture. Furthermore, we observed a significant expansion of a specific T-cell subset, C-X-C motif chemokine legand 13 (CXCL13)-positive T-follicular helper cells. These cells were critical for B-cell recruitment and the structural organization of the tertiary lymphoid structures. In the IA mouse model, CXCL13 neutralization effectively suppressed both aneurysm formation and rupture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      Our finding establishes tertiary lymphoid structures and CXCL13\n                      <jats:sup>+<\/jats:sup>\n                      T follicular helper cells as central elements in IA progression and highlight the CXCL13 signaling axis as a promising therapeutic target for preventing aneurysm advancement.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circresaha.125.328094","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:00:41Z","timestamp":1784624441000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Tertiary Lymphoid Structures and CXCL13 as Targets in 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