{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:25:40Z","timestamp":1788315940234,"version":"build-2803163510"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2026,4,24]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>\n                      Na\n                      <jats:sub>V<\/jats:sub>\n                      (voltage-gated sodium) channels drive cardiac excitability. Although Na\n                      <jats:sub>V<\/jats:sub>\n                      1.5 is the primary cardiac isoform, the composition and functional contributions of non-Na\n                      <jats:sub>V<\/jats:sub>\n                      1.5 isoforms in the heart remain unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      Here, we developed a chemical-genetic mouse model (Na\n                      <jats:sub>V<\/jats:sub>\n                      1.5\n                      <jats:sup>GX\/GX<\/jats:sup>\n                      ) in which Na\n                      <jats:sub>V<\/jats:sub>\n                      1.5 can be selectively and reversibly inhibited by acyl- and aryl-sulfonamide compounds (GX [acyl- and aryl-sulfonamide compounds typically denoted by the name GX-### and associated items] drugs). Cardiac activity was assessed by electrocardiograms in vivo, and optical mapping was used for imaging of ex vivo hearts. Whole-cell voltage-clamp in tandem with validated toxins and isoform-selective inhibitors were used to examine sodium current composition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Na\n                      <jats:sub>V<\/jats:sub>\n                      1.5\n                      <jats:sup>GX\/GX<\/jats:sup>\n                      mice exhibited normal cardiac function at baseline, but acute GX drug administration caused profound conduction defects and arrhythmias. Whole-heart optical mapping revealed dose-dependent chamber-specific sensitivity to Na\n                      <jats:sub>V<\/jats:sub>\n                      1.5 inhibition, with the right ventricle being the most sensitive, followed by the left ventricle, left atrium, and right atrium. Patch-clamp recordings of isolated cardiomyocytes with application of Na\n                      <jats:sub>V<\/jats:sub>\n                      isoform-selective inhibitors showed that Na\n                      <jats:sub>V<\/jats:sub>\n                      1.5 contributed 93% of sodium current in the left ventricle, 79% in the right ventricle, and 78% in the atria. Non-Na\n                      <jats:sub>V<\/jats:sub>\n                      1.5 isoforms were differentially enriched across chambers: Na\n                      <jats:sub>V<\/jats:sub>\n                      1.8 in the left ventricle, Na\n                      <jats:sub>V<\/jats:sub>\n                      1.1\/1.3 in the right ventricle, and Na\n                      <jats:sub>V<\/jats:sub>\n                      1.2\/1.6\/1.7 in the atria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      These results reveal a surprising chamber-specific isoform landscape of cardiac sodium currents, which may underlie the right ventricular predominant phenotype of Brugada syndrome. These data highlight non-Na\n                      <jats:sub>V<\/jats:sub>\n                      1.5 isoforms as potential mediators of chamber-specific cardiac pathologies and as pharmacological targets.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circresaha.125.328159","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T09:00:17Z","timestamp":1774429217000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Sodium Channel Isoform Diversity Underlies Chamber-Specific Cardiac Excitability"],"prefix":"10.1161","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7279-8179","authenticated-orcid":true,"given":"Colin J.","family":"Clark","sequence":"first","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa (C.J.C., C.E.A., A.D., J.D.G., L.G., S.G.T., D.T.I., B.L., C.A.A.)."},{"name":"Abboud Cardiovascular Research Center, University of Iowa (C.J.C., C.E.A., A.D., J.M.D., J.D.G., L.G., S.G.T., H.C., J.-Y.Y., D.T.I., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L., C.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6112-7828","authenticated-orcid":true,"given":"Christian E.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa (C.J.C., C.E.A., A.D., J.D.G., L.G., S.G.T., D.T.I., B.L., C.A.A.)."},{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa (C.E.A., J.M.D., H.C., J.-Y.Y., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L.)."},{"name":"Abboud Cardiovascular Research Center, University of Iowa (C.J.C., C.E.A., A.D., J.M.D., J.D.G., L.G., S.G.T., H.C., J.-Y.Y., D.T.I., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L., C.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7446-1676","authenticated-orcid":true,"given":"Alex","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa (C.J.C., C.E.A., A.D., J.D.G., L.G., S.G.T., D.T.I., B.L., C.A.A.)."},{"name":"Abboud Cardiovascular Research Center, University of Iowa (C.J.C., C.E.A., A.D., J.M.D., J.D.G., L.G., S.G.T., H.C., J.-Y.Y., D.T.I., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L., C.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Dierdorff","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa (C.E.A., J.M.D., H.C., J.-Y.Y., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L.)."},{"name":"Abboud Cardiovascular Research Center, University of Iowa (C.J.C., C.E.A., A.D., J.M.D., J.D.G., L.G., S.G.T., H.C., J.-Y.Y., D.T.I., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L., C.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1923-5312","authenticated-orcid":true,"given":"Jason D.","family":"Galpin","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa (C.J.C., C.E.A., A.D., J.D.G., L.G., S.G.T., D.T.I., B.L., C.A.A.)."},{"name":"Abboud Cardiovascular Research Center, University of Iowa (C.J.C., C.E.A., A.D., J.M.D., J.D.G., L.G., S.G.T., H.C., J.-Y.Y., D.T.I., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L., C.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Gissot","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa (C.J.C., C.E.A., A.D., J.D.G., L.G., S.G.T., D.T.I., B.L., C.A.A.)."},{"name":"Abboud Cardiovascular Research Center, University of Iowa (C.J.C., C.E.A., A.D., J.M.D., J.D.G., L.G., S.G.T., H.C., J.-Y.Y., D.T.I., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L., C.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7205-7343","authenticated-orcid":true,"given":"Samantha G.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa (C.J.C., C.E.A., A.D., J.D.G., L.G., S.G.T., D.T.I., B.L., C.A.A.)."},{"name":"Abboud Cardiovascular Research Center, University of Iowa (C.J.C., C.E.A., A.D., J.M.D., J.D.G., L.G., S.G.T., H.C., J.-Y.Y., D.T.I., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L., C.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5599-5089","authenticated-orcid":true,"given":"Hannah","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa (C.E.A., J.M.D., H.C., J.-Y.Y., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L.)."},{"name":"Abboud Cardiovascular Research Center, University of Iowa (C.J.C., C.E.A., A.D., J.M.D., J.D.G., L.G., S.G.T., H.C., J.-Y.Y., D.T.I., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L., C.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5707-3636","authenticated-orcid":true,"given":"Jin-Young","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa (C.E.A., J.M.D., H.C., J.-Y.Y., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L.)."},{"name":"Abboud Cardiovascular Research Center, University of Iowa (C.J.C., C.E.A., A.D., J.M.D., J.D.G., L.G., S.G.T., H.C., J.-Y.Y., D.T.I., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L., C.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5295-484X","authenticated-orcid":true,"given":"Daniel T.","family":"Infield","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa (C.J.C., C.E.A., A.D., J.D.G., L.G., S.G.T., D.T.I., B.L., C.A.A.)."},{"name":"Abboud Cardiovascular Research Center, University of Iowa (C.J.C., C.E.A., A.D., J.M.D., J.D.G., L.G., S.G.T., H.C., J.-Y.Y., D.T.I., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L., C.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1002-5872","authenticated-orcid":true,"given":"Jared M.","family":"McLendon","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa (C.E.A., J.M.D., H.C., J.-Y.Y., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L.)."},{"name":"Abboud Cardiovascular Research Center, University of Iowa (C.J.C., C.E.A., A.D., J.M.D., J.D.G., L.G., S.G.T., H.C., J.-Y.Y., D.T.I., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L., C.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2673-059X","authenticated-orcid":true,"given":"Jasmyn M.","family":"Hoeger","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa (C.E.A., J.M.D., H.C., J.-Y.Y., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L.)."},{"name":"Abboud Cardiovascular Research Center, University of Iowa (C.J.C., C.E.A., A.D., J.M.D., J.D.G., L.G., S.G.T., H.C., J.-Y.Y., D.T.I., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L., C.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6181-3924","authenticated-orcid":true,"given":"Omar","family":"Rabab\u2019h","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa (C.E.A., J.M.D., H.C., J.-Y.Y., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L.)."},{"name":"Abboud Cardiovascular Research Center, University of Iowa (C.J.C., C.E.A., A.D., J.M.D., J.D.G., L.G., S.G.T., H.C., J.-Y.Y., D.T.I., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L., C.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9067-2016","authenticated-orcid":true,"given":"Peter","family":"Bronk","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Rhode Island Hospital and Brown Medical School, Providence (P.B., B.-R.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keane","family":"Leeds","sequence":"additional","affiliation":[{"name":"Keane Leeds Analytics, LLC, Iowa City, IA (K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9358-795X","authenticated-orcid":true,"given":"William J.","family":"Kutschke","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa (C.E.A., J.M.D., H.C., J.-Y.Y., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L.)."},{"name":"Abboud Cardiovascular Research Center, University of Iowa (C.J.C., C.E.A., A.D., J.M.D., J.D.G., L.G., S.G.T., H.C., J.-Y.Y., D.T.I., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L., C.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Paradee","sequence":"additional","affiliation":[{"name":"Genome Editing Core Facility, Carver College of Medicine, University of Iowa (W.J.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9800-5349","authenticated-orcid":true,"given":"Ryan L.","family":"Boudreau","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa (C.E.A., J.M.D., H.C., J.-Y.Y., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L.)."},{"name":"Abboud Cardiovascular Research Center, University of Iowa (C.J.C., C.E.A., A.D., J.M.D., J.D.G., L.G., S.G.T., H.C., J.-Y.Y., D.T.I., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L., C.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7319-3219","authenticated-orcid":true,"given":"Bum-Rak","family":"Choi","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Rhode Island Hospital and Brown Medical School, Providence (P.B., B.-R.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1506-3947","authenticated-orcid":true,"given":"Barry","family":"London","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa (C.J.C., C.E.A., A.D., J.D.G., L.G., S.G.T., D.T.I., B.L., C.A.A.)."},{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa (C.E.A., J.M.D., H.C., J.-Y.Y., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L.)."},{"name":"Abboud Cardiovascular Research Center, University of Iowa (C.J.C., C.E.A., A.D., J.M.D., J.D.G., L.G., S.G.T., H.C., J.-Y.Y., D.T.I., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L., C.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7975-2744","authenticated-orcid":true,"given":"Christopher A.","family":"Ahern","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa (C.J.C., C.E.A., A.D., J.D.G., L.G., S.G.T., D.T.I., B.L., C.A.A.)."},{"name":"Abboud Cardiovascular Research Center, University of Iowa (C.J.C., C.E.A., A.D., J.M.D., J.D.G., L.G., S.G.T., H.C., J.-Y.Y., D.T.I., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L., C.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-73666-7_2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035455"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201511492"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01372"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2012.06.004"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2022.01.009"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-016-1231-9"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000121421.61896.24"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2627986100"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.261705699"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.5339\/gcsp.2014.58"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.08.017"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.079681"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.12.005"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.126714"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2018.170"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.08.063"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac5464"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-024-00697-0"},{"key":"e_1_3_3_21_2","unstructured":"Andrez JC Bichler PR Chen CA Chowdhury S Decker SM Dehnhardt CM Focken T Grimwood ME Hemeon IW Jia Q et al. Substituted benzamides and methods of use thereof. WIPO WO 2015\/078374 A1. June 4 2015."},{"key":"e_1_3_3_22_2","unstructured":"Layton ME Roecker A Egbertson M Jones K.L.G. Wang X Peng X. Bicycloamine-substituted-n-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels. WIPO WO 2015\/077905 A1. June 4 2015."},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705969"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2020.01.013"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.274.3.H747"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4284"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2025.02.008"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3519"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4324"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005944"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m210882200"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2013.10.029"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-179770"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.124.013290"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa1051"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013698"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002333"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy152"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015119"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316340"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25126596"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.278259"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201711909"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199103213241201"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.08.021"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-410490-7.00001-3"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2010.00144"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.23.e215"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1109\/tbme.1985.325532"},{"key":"e_1_3_3_50_2","unstructured":"Xie C McCullum L Johnson A Pollard T Gow B Moody B. Waveform Database Software Package (WFDB) for Python (version 4.1. 0). PhysioNet; 2023."}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.125.328159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:53:20Z","timestamp":1778579600000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.125.328159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":49,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,4,24]]}},"alternative-id":["10.1161\/CIRCRESAHA.125.328159"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.125.328159","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]},"assertion":[{"value":"2025-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-06","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}