{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:13:44Z","timestamp":1791328424947,"version":"4.3.1"},"reference-count":198,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2026,6,5]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Cardiovascular disease and chronic kidney disease are highly interconnected, with declining kidney function markedly increasing cardiovascular risk. Chronic kidney disease profoundly disrupts lipoprotein metabolism, leading to qualitative and quantitative alterations that modify lipoprotein composition, function, and clearance. These changes influence not only arterial wall cells, promoting vascular inflammation, smooth muscle cell dysfunction, and macrophage inflammation, as well as atherosclerosis, but also renal cell populations, potentially exacerbating kidney injury and accelerating disease progression. In this review, we examine mechanisms by which kidney dysfunction contributes to heightened cardiovascular risk. We place particular emphasis on altered lipoprotein metabolism as a central mediator linking vascular and renal pathology in chronic kidney disease, highlighting how dysfunctional lipoproteins may drive parallel injury responses in both the artery wall and the kidney.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circresaha.126.327361","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:00:37Z","timestamp":1780596037000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Kidney-Vascular Metabolic Crosstalk: Altered Lipoproteins in CKD"],"prefix":"10.1161","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-1039","authenticated-orcid":true,"given":"Keith L.","family":"Saum","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine (K.L.S., S.P.), University of Michigan, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramaniam","family":"Pennathur","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine (K.L.S., S.P.), University of Michigan, Ann Arbor."},{"name":"Department of Molecular and Integrative Physiology (S.P.), University of Michigan, Ann Arbor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3212-772X","authenticated-orcid":true,"given":"Jenny E.","family":"Kanter","sequence":"additional","affiliation":[{"name":"Department of Medicine, UW Medicine Diabetes Institute, University of Washington, Seattle (J.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","first-page":"23","article-title":"Cases and observations illustrative of renal disease, accompanied with the secretion of albuminous urine.","volume":"25","author":"Bright R","year":"1836","unstructured":"Bright R Cases and observations illustrative of renal disease, accompanied with the secretion of albuminous urine. Med Chir Rev. 1836;25:23\u201335.","journal-title":"Med Chir Rev"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.4652"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001184"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.6892"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03700417"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2024.151520"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.13111215"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.11.1130"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409065"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014101034"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014070714"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.02.006"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013713"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2018.11.010"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013050482"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00165.x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-017-1407-8"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09320913"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000142804.27420.5b"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11061231"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.6.1462"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2012.11.001"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12290"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00734.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00060"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010111144"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034107"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2021.100135"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-020-01381-w"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2023.100381"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0320803"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2025.02.010"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.201715"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1433.005"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu022"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.10.054"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016030262"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.05.043"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00747-4"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/09674845.2012.12069133"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.07159.x"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2019.1620206"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.07.003"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7520231"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.529297"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.000559"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1159\/000477766"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.014095"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu111"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.07.755"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1637"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00391.x"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010040365"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013090965"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043545"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810177"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P900003-JLR200"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1159\/000335509"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118657"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00166.x"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.129"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.515"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-011-0549-3"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020091376"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00116.x"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M011163"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.125.327267"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.241463"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.155"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.02.026"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft439"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.10.042"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204233"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2403347"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.321762"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002529"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1246"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-022-02932-2"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60739-3"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67667-2"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2018.09.006"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2210645"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1161524"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1307095"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1308027"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86610"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.122.318290"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P090647"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13412"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-6979508\/v1"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI127308"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.177268"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13744"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2017.10.012"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009121290"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154740"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-021-00592-8"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0548-1"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01423-2"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021040503"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1355-0"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.0000000642"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1592290"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.4103\/0300-1652.171616"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.93900"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2018.05.008"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.321752"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-02219-4"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.03.016"},{"key":"e_1_3_3_112_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2313825120"},{"key":"e_1_3_3_113_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00861.2020"},{"key":"e_1_3_3_114_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.96.6.1677"},{"key":"e_1_3_3_115_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13516"},{"key":"e_1_3_3_116_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1140-4"},{"key":"e_1_3_3_117_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI145800"},{"key":"e_1_3_3_118_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038571"},{"key":"e_1_3_3_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.06.003"},{"key":"e_1_3_3_120_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.125.322712"},{"key":"e_1_3_3_121_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.323100"},{"key":"e_1_3_3_122_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M074427"},{"key":"e_1_3_3_123_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI99315"},{"key":"e_1_3_3_124_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-025-01028-y"},{"key":"e_1_3_3_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2022.155377"},{"key":"e_1_3_3_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.06.055"},{"key":"e_1_3_3_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.10.029"},{"key":"e_1_3_3_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2017.08.005"},{"key":"e_1_3_3_129_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016030317"},{"key":"e_1_3_3_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.01.019"},{"key":"e_1_3_3_131_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2022010048"},{"key":"e_1_3_3_132_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.188995"},{"key":"e_1_3_3_133_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2026.100975"},{"key":"e_1_3_3_134_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-022-02794-8"},{"key":"e_1_3_3_135_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.13121215"},{"key":"e_1_3_3_136_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0415-5"},{"key":"e_1_3_3_137_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2580"},{"key":"e_1_3_3_138_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41642-7"},{"key":"e_1_3_3_139_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0272-6386(12)80393-3"},{"key":"e_1_3_3_140_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2006.00576.x"},{"key":"e_1_3_3_141_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-006-0426-7"},{"key":"e_1_3_3_142_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000014"},{"key":"e_1_3_3_143_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00316.2013"},{"key":"e_1_3_3_144_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv459"},{"key":"e_1_3_3_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2025.100763"},{"key":"e_1_3_3_146_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305609"},{"key":"e_1_3_3_147_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35297-z"},{"key":"e_1_3_3_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.08.026"},{"key":"e_1_3_3_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114253"},{"key":"e_1_3_3_150_2","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000112"},{"key":"e_1_3_3_151_2","doi-asserted-by":"publisher","DOI":"10.1159\/000232596"},{"key":"e_1_3_3_152_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.312509"},{"key":"e_1_3_3_153_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-023-00354-3"},{"key":"e_1_3_3_154_2","doi-asserted-by":"publisher","DOI":"10.2337\/db25-0282"},{"key":"e_1_3_3_155_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.11.033"},{"key":"e_1_3_3_156_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.122.317583"},{"key":"e_1_3_3_157_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.175257"},{"key":"e_1_3_3_158_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac161"},{"key":"e_1_3_3_159_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.137289"},{"key":"e_1_3_3_160_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2011.02514.x"},{"key":"e_1_3_3_161_2","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0575"},{"key":"e_1_3_3_162_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00075.2018"},{"key":"e_1_3_3_163_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abf7084"},{"key":"e_1_3_3_164_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.124.319847"},{"key":"e_1_3_3_165_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-022-00208-4"},{"key":"e_1_3_3_166_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.124.325841"},{"key":"e_1_3_3_167_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-59997-4"},{"key":"e_1_3_3_168_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-052824-084232"},{"key":"e_1_3_3_169_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.312434"},{"key":"e_1_3_3_170_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202002738"},{"key":"e_1_3_3_171_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P040501"},{"key":"e_1_3_3_172_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127507"},{"key":"e_1_3_3_173_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI79641"},{"key":"e_1_3_3_174_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI125316"},{"key":"e_1_3_3_175_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.10.019"},{"key":"e_1_3_3_176_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017030350"},{"key":"e_1_3_3_177_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.86976"},{"key":"e_1_3_3_178_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.161783"},{"key":"e_1_3_3_179_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2023.07.004"},{"key":"e_1_3_3_180_2","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000000000000153"},{"key":"e_1_3_3_181_2","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0090"},{"key":"e_1_3_3_182_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.02.035"},{"key":"e_1_3_3_183_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017030314"},{"key":"e_1_3_3_184_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107954"},{"key":"e_1_3_3_185_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI164486"},{"key":"e_1_3_3_186_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3762"},{"key":"e_1_3_3_187_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.5150"},{"key":"e_1_3_3_188_2","doi-asserted-by":"publisher","DOI":"10.4172\/jpb.S14-002"},{"key":"e_1_3_3_189_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-023-05078-y"},{"key":"e_1_3_3_190_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo14110641"},{"key":"e_1_3_3_191_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207444"},{"key":"e_1_3_3_192_2","doi-asserted-by":"publisher","DOI":"10.1152\/AJPRENAL.90761.2008"},{"key":"e_1_3_3_193_2","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-17-0453"},{"key":"e_1_3_3_194_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0306575"},{"key":"e_1_3_3_195_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016101085"},{"key":"e_1_3_3_196_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M077222"},{"key":"e_1_3_3_197_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.130317"},{"key":"e_1_3_3_198_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.102960"},{"key":"e_1_3_3_199_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.105502"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.126.327361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:01:49Z","timestamp":1781892109000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.126.327361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,5]]},"references-count":198,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,6,5]]}},"alternative-id":["10.1161\/CIRCRESAHA.126.327361"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.126.327361","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,5]]},"assertion":[{"value":"2026-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}