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In this review, we examine the weight-dependent and weight-independent mechanisms by which the GLP-1 axis affects cardiovascular risk, with a particular focus on lipoprotein metabolism and adipose tissue plasticity. We explore how GLP-1R agonists exert favorable effects on postprandial lipoprotein metabolism and examine potential mechanisms by which they influence adipose tissue function to enhance metabolic health. Finally, we discuss outstanding questions regarding incretin-based therapies and present a potential framework for expanding the use of GLP-1R agonists from weight loss agents into components of cardiovascular risk reduction strategies. Looking ahead, it is clear that the GLP-1 axis is a pleiotropic regulator of cardiometabolic health whose full therapeutic potential has not yet been realized.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circresaha.126.328680","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:00:37Z","timestamp":1780596037000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Adipose Tissue Plasticity, Lipoprotein Metabolism, and Cardiovascular Risk: The Emerging Role of the GLP-1 Axis"],"prefix":"10.1161","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9172-6787","authenticated-orcid":true,"given":"Giuliana G.","family":"Repetti","sequence":"first","affiliation":[{"name":"Department of Medicine (G.G.R., E.D.A., T.S.), David Geffen School of Medicine, University of California, Los Angeles, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5290-0738","authenticated-orcid":true,"given":"E. 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