{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:16:35Z","timestamp":1761707795055},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2005,6,21]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Femoropopliteal percutaneous transluminal angioplasty (PTA) remains limited by restenosis. Although vascular brachytherapy may be effective in reducing restenosis, external beam radiation would be more practical to administer after PTA.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            After femoropopliteal PTA without stent placement, 99 patients were randomly assigned to 0 Gy (placebo; n=24), 7 Gy (n=24), 10.5 Gy (n=26), or 14 Gy (n=25) of external beam radiation of the PTA site (with a 3-cm margin at both extremities) in 1 session 24 hours after PTA. The primary end point was minimum lumen diameter on quantitative angiography 1 year after PTA. One year after PTA, the mean minimum lumen diameter was 1.92, 1.64, 1.92, and 2.91 mm, respectively, for the 0-, 7-, 10.5-, and 14-Gy groups (\n            <jats:italic>P<\/jats:italic>\n            =0.0072 for 0 versus 14 Gy). Mean luminal loss was 1.14, 1.27, 1.08, and 0.14 mm, respectively, for the 4 groups (\n            <jats:italic>P<\/jats:italic>\n            =0.0072 for 0 versus 14 Gy). Restenosis &gt;50% was present in 50%, 65%, 48%, and 25% of patients, respectively, for the 0-, 7-, 10.5-, and 14-Gy groups (\n            <jats:italic>P<\/jats:italic>\n            =0.072). At 18 months, repeated revascularizations were required in 25% of patients in the 0-Gy group versus 12% of patients in the 14-Gy group (\n            <jats:italic>P<\/jats:italic>\n            =0.24).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            A single session of external beam radiation of 14 Gy of the femoropopliteal angioplasty site significantly reduces restenosis at 1 year.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.104.502179","type":"journal-article","created":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T03:43:53Z","timestamp":1118807033000},"page":"3310-3315","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["External Beam Radiation to Prevent Restenosis After Superficial Femoral Artery Balloon Angioplasty"],"prefix":"10.1161","volume":"111","author":[{"given":"Eric","family":"Therasse","sequence":"first","affiliation":[{"name":"From the Departments of Radiology (E.T., V.L.O., G.S.) and Radiation Oncology (D.D.), Centre Hospitalier de l\u2019Universite\u0301 de Montre\u0301al (CHUM), and the Departments of Radiology (J.L.), Medicine (J.-C.T.), and Biostatistics (M.-C.G.), Montreal Heart Institute, Montreal, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Donath","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (E.T., V.L.O., G.S.) and Radiation Oncology (D.D.), Centre Hospitalier de l\u2019Universite\u0301 de Montre\u0301al (CHUM), and the Departments of Radiology (J.L.), Medicine (J.-C.T.), and Biostatistics (M.-C.G.), Montreal Heart Institute, Montreal, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Lespe\u0301rance","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (E.T., V.L.O., G.S.) and Radiation Oncology (D.D.), Centre Hospitalier de l\u2019Universite\u0301 de Montre\u0301al (CHUM), and the Departments of Radiology (J.L.), Medicine (J.-C.T.), and Biostatistics (M.-C.G.), Montreal Heart Institute, Montreal, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Tardif","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (E.T., V.L.O., G.S.) and Radiation Oncology (D.D.), Centre Hospitalier de l\u2019Universite\u0301 de Montre\u0301al (CHUM), and the Departments of Radiology (J.L.), Medicine (J.-C.T.), and Biostatistics (M.-C.G.), Montreal Heart Institute, Montreal, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Claude","family":"Guertin","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (E.T., V.L.O., G.S.) and Radiation Oncology (D.D.), Centre Hospitalier de l\u2019Universite\u0301 de Montre\u0301al (CHUM), and the Departments of Radiology (J.L.), Medicine (J.-C.T.), and Biostatistics (M.-C.G.), Montreal Heart Institute, Montreal, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent L.","family":"Oliva","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (E.T., V.L.O., G.S.) and Radiation Oncology (D.D.), Centre Hospitalier de l\u2019Universite\u0301 de Montre\u0301al (CHUM), and the Departments of Radiology (J.L.), Medicine (J.-C.T.), and Biostatistics (M.-C.G.), Montreal Heart Institute, Montreal, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Soulez","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (E.T., V.L.O., G.S.) and Radiation Oncology (D.D.), Centre Hospitalier de l\u2019Universite\u0301 de Montre\u0301al (CHUM), and the Departments of Radiology (J.L.), Medicine (J.-C.T.), and Biostatistics (M.-C.G.), Montreal Heart Institute, Montreal, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"251","volume":"18","year":"1999","unstructured":"Zdanowski Z, Albrechtsson U, Lundin A, Jonung T, Ribbe E, Thorne J, Norgren L. 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Comparison of accuracy and precision of quantitative coronary arterial analysis between cinefilm and digital systems. In: Reiber JHC Serruys PW eds. Progress in Quantitative Coronary Arteriography. Dordrecht Netherlands: Kluwer Academic Publishers; 1994: 67\u201385.","DOI":"10.1007\/978-94-011-1172-0_5"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2312030421"},{"key":"e_1_3_2_12_2","first-page":"S250.","volume":"57","year":"2003","unstructured":"Pokrajac B, Schmid R, Poetter R, Wolfram R, Kirisits C, Mendl H, Kopp M, Minar E. Endovascular brachytherapy prevents restenosis after femoropopliteal angioplasty: results of the Vienna-3 multicenter study. Int J Radiat Oncol Biol Phys. 2003; 57: S250. Abstract","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/152660280301000221"},{"key":"e_1_3_2_14_2","unstructured":"Waksman R on behalf of the PARIS Investigators. High-dose rate brachytherapy for prevention of restenosis following angioplasty of narrowed femoral-popliteal arteries: preliminary results from a prospective double-blind randomized multicenter study. Available at: http:\/\/www.crtonline.org\/documents\/paris%20crt.ppt. Accessed August 23 2004."},{"key":"e_1_3_2_15_2","first-page":"241","volume":"9","year":"2002","unstructured":"Hofmann WJ, Kopp M, Kofler B, Ugurluoglu A, Kogelnik D, Magometschnigg H. Preliminary observations on the need for control angiography after peripheral endovascular brachytherapy using a centering balloon. 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