{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:02:18Z","timestamp":1792735338237,"version":"4.5.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9_supplement","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2005,8,30]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Several clinical studies are evaluating the therapeutic potential of delivery of various progenitor cells for treatment of injured hearts. However, the actual fate of delivered cells has not been thoroughly assessed for any cell type. We evaluated the short-term fate of peripheral blood mononuclear cells (PBMNCs) after intramyocardial (IM), intracoronary (IC), and interstitial retrograde coronary venous (IRV) delivery in an ischemic swine model.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Myocardial ischemia was created by 45 minutes of balloon occlusion of the left anterior descending coronary artery. Six days later, 10\n            <jats:sup>7<\/jats:sup>\n            <jats:sup>111<\/jats:sup>\n            indium-oxine\u2013labeled human PBMNCs were delivered by IC (n=5), IM (n=6), or IRV (n=5) injection. The distribution of injected cells was assessed by \u03b3-emission counting of harvested organs. For each delivery method, a significant fraction of delivered cells exited the heart into the pulmonary circulation, with 26\u00b13% (IM), 47\u00b11% (IC), and 43\u00b13% (IRV) of cells found localized in the lungs. Within the myocardium, significantly more cells were retained after IM injection (11\u00b13%) compared with IC (2.6\u00b10.3%) (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05) delivery. IRV delivery efficiency (3.2\u00b11%) trended lower than IM infusion for PBMNCs, but this difference did not reach significance. The IM technique displayed the greatest variability in delivery efficiency by comparison with the other techniques.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            The majority of delivered cells is not retained in the heart for each delivery modality. The clinical implications of these findings are potentially significant, because cells with proangiogenic or other therapeutic effects could conceivably have effects in other organs to which they are not primarily targeted but to which they are distributed. Also, we found that although IM injection was more efficient, it was less consistent in the delivery of PBMNCs compared with IC and IRV techniques.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.104.526749","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T03:23:18Z","timestamp":1625282598000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":255,"title":["Radiolabeled Cell Distribution After Intramyocardial, Intracoronary, and Interstitial Retrograde Coronary Venous Delivery"],"prefix":"10.1161","volume":"112","author":[{"given":"Dongming","family":"Hou","sequence":"first","affiliation":[{"name":"From the Indiana University School of Medicine (D.H., E.A.-S.Y., P.Z., P.R., B.H.J., K.L.M.), the Krannert Institute of Cardiology (D.H., E.A.-S.Y., B.H.J., K.L.M.), and the Richard L. Roudebush VA Medical Center (K.L.M.), Indianapolis, Ind, and Stanford University School of Medicine (T.J.B., E.T.P., A.C.Y., P.G.Y.), Stanford, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyas Al-Shaykh","family":"Youssef","sequence":"additional","affiliation":[{"name":"From the Indiana University School of Medicine (D.H., E.A.-S.Y., P.Z., P.R., B.H.J., K.L.M.), the Krannert Institute of Cardiology (D.H., E.A.-S.Y., B.H.J., K.L.M.), and the Richard L. Roudebush VA Medical Center (K.L.M.), Indianapolis, Ind, and Stanford University School of Medicine (T.J.B., E.T.P., A.C.Y., P.G.Y.), Stanford, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd J.","family":"Brinton","sequence":"additional","affiliation":[{"name":"From the Indiana University School of Medicine (D.H., E.A.-S.Y., P.Z., P.R., B.H.J., K.L.M.), the Krannert Institute of Cardiology (D.H., E.A.-S.Y., B.H.J., K.L.M.), and the Richard L. Roudebush VA Medical Center (K.L.M.), Indianapolis, Ind, and Stanford University School of Medicine (T.J.B., E.T.P., A.C.Y., P.G.Y.), Stanford, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Indiana University School of Medicine (D.H., E.A.-S.Y., P.Z., P.R., B.H.J., K.L.M.), the Krannert Institute of Cardiology (D.H., E.A.-S.Y., B.H.J., K.L.M.), and the Richard L. Roudebush VA Medical Center (K.L.M.), Indianapolis, Ind, and Stanford University School of Medicine (T.J.B., E.T.P., A.C.Y., P.G.Y.), Stanford, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Rogers","sequence":"additional","affiliation":[{"name":"From the Indiana University School of Medicine (D.H., E.A.-S.Y., P.Z., P.R., B.H.J., K.L.M.), the Krannert Institute of Cardiology (D.H., E.A.-S.Y., B.H.J., K.L.M.), and the Richard L. Roudebush VA Medical Center (K.L.M.), Indianapolis, Ind, and Stanford University School of Medicine (T.J.B., E.T.P., A.C.Y., P.G.Y.), Stanford, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik T.","family":"Price","sequence":"additional","affiliation":[{"name":"From the Indiana University School of Medicine (D.H., E.A.-S.Y., P.Z., P.R., B.H.J., K.L.M.), the Krannert Institute of Cardiology (D.H., E.A.-S.Y., B.H.J., K.L.M.), and the Richard L. Roudebush VA Medical Center (K.L.M.), Indianapolis, Ind, and Stanford University School of Medicine (T.J.B., E.T.P., A.C.Y., P.G.Y.), Stanford, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan C.","family":"Yeung","sequence":"additional","affiliation":[{"name":"From the Indiana University School of Medicine (D.H., E.A.-S.Y., P.Z., P.R., B.H.J., K.L.M.), the Krannert Institute of Cardiology (D.H., E.A.-S.Y., B.H.J., K.L.M.), and the Richard L. 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