{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:43:30Z","timestamp":1790109810883,"version":"4.0.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2005,6,21]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>Background\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Despite successful surgical correction, morbidity of patients with coarctation of the aorta is increased. It is well known that these patients have impaired elastic properties of the prestenotic arteries. To find out whether these abnormalities are primarily present or develop later, we studied 17 newborns before and early after surgical repair.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods and Results\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Aortic wall stiffness index and distensibility were calculated using ascending and abdominal aortic diameters determined by M-mode echocardiography and noninvasive estimation of aortic pulse pressure in the right arm and leg. Seventeen patients with aortic coarctation (mean age, 20\u00b126 days) were compared with 17 normal neonates (mean age, 13\u00b17 days) preoperatively and postoperatively (10\u00b16 days after surgery). Ascending aortic distensibility in patients was significantly reduced preoperatively (79\u00b158 versus 105\u00b136;\n                    <jats:italic>P<\/jats:italic>\n                    =0.03) and postoperatively (65\u00b124 versus 105\u00b136;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.005). Preoperative and postoperative ascending aortic stiffness index was higher in patients (preoperative, 5.2\u00b14.4 versus 2.7\u00b10.9;\n                    <jats:italic>P<\/jats:italic>\n                    =0.04; postoperative, 4.0\u00b11.6 versus 2.7\u00b10.9;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.005). Elastic properties of the descending aorta did not differ preoperatively or postoperatively compared with those in normal subjects.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusions\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Elastic properties of the prestenotic aorta of patients with coarctation seem to be impaired primarily, even in neonates, and remain unchanged early after successful operation. Surgical correction does not resolve inborn pathology of the prestenotic aortic vascular bed.\n                  <\/jats:p>","DOI":"10.1161\/circulationaha.104.529792","type":"journal-article","created":{"date-parts":[[2005,6,14]],"date-time":"2005-06-14T23:43:53Z","timestamp":1118792633000},"page":"3269-3273","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":148,"title":["Impaired Elastic Properties of the Ascending Aorta in Newborns Before and Early After Successful Coarctation Repair"],"prefix":"10.1161","volume":"111","author":[{"given":"Manfred","family":"Vogt","sequence":"first","affiliation":[{"name":"From the Department of Pediatric Cardiology and Congenital Heart Disease (M.V., A.K., J.H.) and the Department of Cardiovascular Surgery (M.K.), Deutsches Herzzentrum Mu\u0308nchen, Technische Universita\u0308t, Munich, Germany; Clinical Division of Pediatric Cardiology (D.B.), Clinical Department of Pediatrics, Innsbruck Medical University, Innsbruck, Austria; Research Group for Biomedical Data Mining (C.B.), University for Health Sciences, Medical Informatics and Technology, Hall, Austria; Institut fu\u0308r..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Ku\u0308hn","sequence":"additional","affiliation":[{"name":"From the Department of Pediatric Cardiology and Congenital Heart Disease (M.V., A.K., J.H.) and the Department of Cardiovascular Surgery (M.K.), Deutsches Herzzentrum Mu\u0308nchen, Technische Universita\u0308t, Munich, Germany; Clinical Division of Pediatric Cardiology (D.B.), Clinical Department of Pediatrics, Innsbruck Medical University, Innsbruck, Austria; Research Group for Biomedical Data Mining (C.B.), University for Health Sciences, Medical Informatics and Technology, Hall, Austria; Institut fu\u0308r..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"From the Department of Pediatric Cardiology and Congenital Heart Disease (M.V., A.K., J.H.) and the Department of Cardiovascular Surgery (M.K.), Deutsches Herzzentrum Mu\u0308nchen, Technische Universita\u0308t, Munich, Germany; Clinical Division of Pediatric Cardiology (D.B.), Clinical Department of Pediatrics, Innsbruck Medical University, Innsbruck, Austria; Research Group for Biomedical Data Mining (C.B.), University for Health Sciences, Medical Informatics and Technology, Hall, Austria; Institut fu\u0308r..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"From the Department of Pediatric Cardiology and Congenital Heart Disease (M.V., A.K., J.H.) and the Department of Cardiovascular Surgery (M.K.), Deutsches Herzzentrum Mu\u0308nchen, Technische Universita\u0308t, Munich, Germany; Clinical Division of Pediatric Cardiology (D.B.), Clinical Department of Pediatrics, Innsbruck Medical University, Innsbruck, Austria; Research Group for Biomedical Data Mining (C.B.), University for Health Sciences, Medical Informatics and Technology, Hall, Austria; Institut fu\u0308r..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymonde","family":"Busch","sequence":"additional","affiliation":[{"name":"From the Department of Pediatric Cardiology and Congenital Heart Disease (M.V., A.K., J.H.) and the Department of Cardiovascular Surgery (M.K.), Deutsches Herzzentrum Mu\u0308nchen, Technische Universita\u0308t, Munich, Germany; Clinical Division of Pediatric Cardiology (D.B.), Clinical Department of Pediatrics, Innsbruck Medical University, Innsbruck, Austria; Research Group for Biomedical Data Mining (C.B.), University for Health Sciences, Medical Informatics and Technology, Hall, Austria; Institut fu\u0308r..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kostolny","sequence":"additional","affiliation":[{"name":"From the Department of Pediatric Cardiology and Congenital Heart Disease (M.V., A.K., J.H.) and the Department of Cardiovascular Surgery (M.K.), Deutsches Herzzentrum Mu\u0308nchen, Technische Universita\u0308t, Munich, Germany; Clinical Division of Pediatric Cardiology (D.B.), Clinical Department of Pediatrics, Innsbruck Medical University, Innsbruck, Austria; Research Group for Biomedical Data Mining (C.B.), University for Health Sciences, Medical Informatics and Technology, Hall, Austria; Institut fu\u0308r..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hess","sequence":"additional","affiliation":[{"name":"From the Department of Pediatric Cardiology and Congenital Heart Disease (M.V., A.K., J.H.) and the Department of Cardiovascular Surgery (M.K.), Deutsches Herzzentrum Mu\u0308nchen, Technische Universita\u0308t, Munich, Germany; Clinical Division of Pediatric Cardiology (D.B.), Clinical Department of Pediatrics, Innsbruck Medical University, Innsbruck, Austria; Research Group for Biomedical Data Mining (C.B.), University for Health Sciences, Medical Informatics and Technology, Hall, Austria; Institut fu\u0308r..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.80.4.2791247"},{"key":"e_1_3_2_2_2","first-page":"1541","volume":"81","year":"1983","unstructured":"Clarkson PM, Nicholson MR, Barratt-Boyes BG, Neutze JM, Whitlock RM. 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