{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:57:30Z","timestamp":1791197850992,"version":"4.1.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2005,7,19]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            The detection and differentiation of intracardiac masses is still challenging and may include neoplasms and thrombi. The aim of this study was the investigation of a targeted, fibrin-specific contrast agent (EP-2104R) for molecular targeted magnetic resonance imaging (MRI) of left atrial clots.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Chronic human thrombi were surgically implanted in the left atrial appendage of 5 swine. Molecular MRI was performed with a navigator-gated, free-breathing, cardiac-triggered 3D inversion-recovery, black-blood, gradient-echo sequence before and after systemic administration of 4 \u03bcmol\/kg EP-2104R. MR images were analyzed by 2 investigators, and the contrast-to-noise ratio was calculated. Location of clots was confirmed by autopsy, and the gadolinium concentration in the clots was assessed. Before contrast agent administration, thrombi were not visible on black-blood MR images. After contrast administration, all atrial clots (n=5) were selectively visualized as white spots with a high contrast-to-noise ratio (clot\/blood, 29.7\u00b18.0). The gadolinium concentration in the clots averaged 74\u00b145 \u03bcmol\/L.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            The fibrin-specific MR contrast agent EP-2104R allows for selective and high-contrast visualization of left atrial clots by means of molecular targeted MRI.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.104.529941","type":"journal-article","created":{"date-parts":[[2005,7,12]],"date-time":"2005-07-12T00:33:52Z","timestamp":1121128432000},"page":"396-399","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":99,"title":["Molecular Magnetic Resonance Imaging of Atrial Clots in a Swine Model"],"prefix":"10.1161","volume":"112","author":[{"given":"Elmar","family":"Spuentrup","sequence":"first","affiliation":[{"name":"From the Departments of Diagnostic Radiology (E.S., S.H., M.K., R.W.G., A.B.), Thoracic and Cardiovascular Surgery (B.F., T.B.), and Laboratory Animal Science (S.K.), Aachen Technical University, Aachen, Germany; EPIX Pharmaceuticals (A.J.W., P.B.G., E.C.P.), Cambridge, Mass; and the Departments of Medicine, Cardiovascular Division (R.M.B., W.J.M.), and Radiology (W.J.M.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Fausten","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic Radiology (E.S., S.H., M.K., R.W.G., A.B.), Thoracic and Cardiovascular Surgery (B.F., T.B.), and Laboratory Animal Science (S.K.), Aachen Technical University, Aachen, Germany; EPIX Pharmaceuticals (A.J.W., P.B.G., E.C.P.), Cambridge, Mass; and the Departments of Medicine, Cardiovascular Division (R.M.B., W.J.M.), and Radiology (W.J.M.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Kinzel","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic Radiology (E.S., S.H., M.K., R.W.G., A.B.), Thoracic and Cardiovascular Surgery (B.F., T.B.), and Laboratory Animal Science (S.K.), Aachen Technical University, Aachen, Germany; EPIX Pharmaceuticals (A.J.W., P.B.G., E.C.P.), Cambridge, Mass; and the Departments of Medicine, Cardiovascular Division (R.M.B., W.J.M.), and Radiology (W.J.M.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea J.","family":"Wiethoff","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic Radiology (E.S., S.H., M.K., R.W.G., A.B.), Thoracic and Cardiovascular Surgery (B.F., T.B.), and Laboratory Animal Science (S.K.), Aachen Technical University, Aachen, Germany; EPIX Pharmaceuticals (A.J.W., P.B.G., E.C.P.), Cambridge, Mass; and the Departments of Medicine, Cardiovascular Division (R.M.B., W.J.M.), and Radiology (W.J.M.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene M.","family":"Botnar","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic Radiology (E.S., S.H., M.K., R.W.G., A.B.), Thoracic and Cardiovascular Surgery (B.F., T.B.), and Laboratory Animal Science (S.K.), Aachen Technical University, Aachen, Germany; EPIX Pharmaceuticals (A.J.W., P.B.G., E.C.P.), Cambridge, Mass; and the Departments of Medicine, Cardiovascular Division (R.M.B., W.J.M.), and Radiology (W.J.M.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip B.","family":"Graham","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic Radiology (E.S., S.H., M.K., R.W.G., A.B.), Thoracic and Cardiovascular Surgery (B.F., T.B.), and Laboratory Animal Science (S.K.), Aachen Technical University, Aachen, Germany; EPIX Pharmaceuticals (A.J.W., P.B.G., E.C.P.), Cambridge, Mass; and the Departments of Medicine, Cardiovascular Division (R.M.B., W.J.M.), and Radiology (W.J.M.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Haller","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic Radiology (E.S., S.H., M.K., R.W.G., A.B.), Thoracic and Cardiovascular Surgery (B.F., T.B.), and Laboratory Animal Science (S.K.), Aachen Technical University, Aachen, Germany; EPIX Pharmaceuticals (A.J.W., P.B.G., E.C.P.), Cambridge, Mass; and the Departments of Medicine, Cardiovascular Division (R.M.B., W.J.M.), and Radiology (W.J.M.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Katoh","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic Radiology (E.S., S.H., M.K., R.W.G., A.B.), Thoracic and Cardiovascular Surgery (B.F., T.B.), and Laboratory Animal Science (S.K.), Aachen Technical University, Aachen, Germany; EPIX Pharmaceuticals (A.J.W., P.B.G., E.C.P.), Cambridge, Mass; and the Departments of Medicine, Cardiovascular Division (R.M.B., W.J.M.), and Radiology (W.J.M.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Edward C.","family":"Parsons","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic Radiology (E.S., S.H., M.K., R.W.G., A.B.), Thoracic and Cardiovascular Surgery (B.F., T.B.), and Laboratory Animal Science (S.K.), Aachen Technical University, Aachen, Germany; EPIX Pharmaceuticals (A.J.W., P.B.G., E.C.P.), Cambridge, Mass; and the Departments of Medicine, Cardiovascular Division (R.M.B., W.J.M.), and Radiology (W.J.M.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren J.","family":"Manning","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic Radiology (E.S., S.H., M.K., R.W.G., A.B.), Thoracic and Cardiovascular Surgery (B.F., T.B.), and Laboratory Animal Science (S.K.), Aachen Technical University, Aachen, Germany; EPIX Pharmaceuticals (A.J.W., P.B.G., E.C.P.), Cambridge, Mass; and the Departments of Medicine, Cardiovascular Division (R.M.B., W.J.M.), and Radiology (W.J.M.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Busch","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic Radiology (E.S., S.H., M.K., R.W.G., A.B.), Thoracic and Cardiovascular Surgery (B.F., T.B.), and Laboratory Animal Science (S.K.), Aachen Technical University, Aachen, Germany; EPIX Pharmaceuticals (A.J.W., P.B.G., E.C.P.), Cambridge, Mass; and the Departments of Medicine, Cardiovascular Division (R.M.B., W.J.M.), and Radiology (W.J.M.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf W.","family":"Gu\u0308nther","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic Radiology (E.S., S.H., M.K., R.W.G., A.B.), Thoracic and Cardiovascular Surgery (B.F., T.B.), and Laboratory Animal Science (S.K.), Aachen Technical University, Aachen, Germany; EPIX Pharmaceuticals (A.J.W., P.B.G., E.C.P.), Cambridge, Mass; and the Departments of Medicine, Cardiovascular Division (R.M.B., W.J.M.), and Radiology (W.J.M.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"Buecker","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic Radiology (E.S., S.H., M.K., R.W.G., A.B.), Thoracic and Cardiovascular Surgery (B.F., T.B.), and Laboratory Animal Science (S.K.), Aachen Technical University, Aachen, Germany; EPIX Pharmaceuticals (A.J.W., P.B.G., E.C.P.), Cambridge, Mass; and the Departments of Medicine, Cardiovascular Division (R.M.B., W.J.M.), and Radiology (W.J.M.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000090350.73614.0f"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mje.2002.123961"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00560-D"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.77.1.3335075"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-002-1789-0"},{"key":"e_1_3_3_6_2","first-page":"289","volume":"35","year":"1994","unstructured":"Reddy DB, Jena A, Venugopal P. 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