{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:57:17Z","timestamp":1791014237518,"version":"4.1.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2006,7,25]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            The Fontan procedure is a successful palliation for children with single-ventricle physiology; however, many will eventually require heart transplantation. The purpose of this study was to determine risk factors for death awaiting transplantation and to examine results after transplantation in Fontan patients.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            A retrospective, multi-institutional review was performed of 97 Fontan patients &lt;18 years of age listed at 17 Pediatric Heart Transplant Study centers from 1993 to 2001. Mean age at listing was 9.7 years (0.5 to 17.9 years); 25% were &lt;4 years old; 53% were United Network for Organ Sharing status 1; 18% required ventilator support. Pretransplantation survival was 78% at 6 months and 74% at 12 months and was similar to 243 children with other congenital heart disease (CHD) and 747 children without congenital heart disease (No-CHD), who were also awaiting transplantation. Patients who were younger, status 1, had shorter interval since Fontan, or were on a ventilator were more likely to die while waiting. At 6 months, the probability of receiving a transplant was similar for status 1 and 2 (65% versus 68%); however, the probability of death was higher for status 1 (22% versus 5%). Seventy patients underwent transplantation. Survival was 76% at 1 year, 70% at 3 years, and 68% at 5 years, slightly less than CHD and No-CHD patients. Causes of death included infection (30%), graft failure (17%), rejection (13%), sudden death (13%), and graft coronary artery disease (9%). Protein-losing enteropathy (present in 34 patients) resolved in all who survived &gt;30 days after transplantation.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Heart transplantation is an effective therapy for pediatric patients with a failed Fontan. Although early posttransplantation survival is slightly lower than other patients with CHD, long-term results are encouraging, and protein-losing enteropathy can be expected to resolve.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.105.548016","type":"journal-article","created":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T04:35:26Z","timestamp":1153197326000},"page":"273-280","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":239,"title":["Outcome of Listing for Cardiac Transplantation for Failed Fontan"],"prefix":"10.1161","volume":"114","author":[{"given":"D.","family":"Bernstein","sequence":"first","affiliation":[{"name":"From Stanford University (D.B., C.C., P.G.), Stanford, Calif; The University of Alabama (D.N., J.K.K.), Birmingham; Columbia University (L.J.A., D.H.), New York, NY; Children\u2019s Hospital Boston and Harvard Medical School (E.D.B.), Boston, Mass; Washington University (C.E.C.), St. Louis, Mo; and The University of Arkansas (W.R.M.), Little Rock."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Naftel","sequence":"additional","affiliation":[{"name":"From Stanford University (D.B., C.C., P.G.), Stanford, Calif; The University of Alabama (D.N., J.K.K.), Birmingham; Columbia University (L.J.A., D.H.), New York, NY; Children\u2019s Hospital Boston and Harvard Medical School (E.D.B.), Boston, Mass; Washington University (C.E.C.), St. Louis, Mo; and The University of Arkansas (W.R.M.), Little Rock."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Chin","sequence":"additional","affiliation":[{"name":"From Stanford University (D.B., C.C., P.G.), Stanford, Calif; The University of Alabama (D.N., J.K.K.), Birmingham; Columbia University (L.J.A., D.H.), New York, NY; Children\u2019s Hospital Boston and Harvard Medical School (E.D.B.), Boston, Mass; Washington University (C.E.C.), St. Louis, Mo; and The University of Arkansas (W.R.M.), Little Rock."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.J.","family":"Addonizio","sequence":"additional","affiliation":[{"name":"From Stanford University (D.B., C.C., P.G.), Stanford, Calif; The University of Alabama (D.N., J.K.K.), Birmingham; Columbia University (L.J.A., D.H.), New York, NY; Children\u2019s Hospital Boston and Harvard Medical School (E.D.B.), Boston, Mass; Washington University (C.E.C.), St. Louis, Mo; and The University of Arkansas (W.R.M.), Little Rock."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Gamberg","sequence":"additional","affiliation":[{"name":"From Stanford University (D.B., C.C., P.G.), Stanford, Calif; The University of Alabama (D.N., J.K.K.), Birmingham; Columbia University (L.J.A., D.H.), New York, NY; Children\u2019s Hospital Boston and Harvard Medical School (E.D.B.), Boston, Mass; Washington University (C.E.C.), St. Louis, Mo; and The University of Arkansas (W.R.M.), Little Rock."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.D.","family":"Blume","sequence":"additional","affiliation":[{"name":"From Stanford University (D.B., C.C., P.G.), Stanford, Calif; The University of Alabama (D.N., J.K.K.), Birmingham; Columbia University (L.J.A., D.H.), New York, NY; Children\u2019s Hospital Boston and Harvard Medical School (E.D.B.), Boston, Mass; Washington University (C.E.C.), St. Louis, Mo; and The University of Arkansas (W.R.M.), Little Rock."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Hsu","sequence":"additional","affiliation":[{"name":"From Stanford University (D.B., C.C., P.G.), Stanford, Calif; The University of Alabama (D.N., J.K.K.), Birmingham; Columbia University (L.J.A., D.H.), New York, NY; Children\u2019s Hospital Boston and Harvard Medical School (E.D.B.), Boston, Mass; Washington University (C.E.C.), St. Louis, Mo; and The University of Arkansas (W.R.M.), Little Rock."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.E.","family":"Canter","sequence":"additional","affiliation":[{"name":"From Stanford University (D.B., C.C., P.G.), Stanford, Calif; The University of Alabama (D.N., J.K.K.), Birmingham; Columbia University (L.J.A., D.H.), New York, NY; Children\u2019s Hospital Boston and Harvard Medical School (E.D.B.), Boston, Mass; Washington University (C.E.C.), St. Louis, Mo; and The University of Arkansas (W.R.M.), Little Rock."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.K.","family":"Kirklin","sequence":"additional","affiliation":[{"name":"From Stanford University (D.B., C.C., P.G.), Stanford, Calif; The University of Alabama (D.N., J.K.K.), Birmingham; Columbia University (L.J.A., D.H.), New York, NY; Children\u2019s Hospital Boston and Harvard Medical School (E.D.B.), Boston, Mass; Washington University (C.E.C.), St. Louis, Mo; and The University of Arkansas (W.R.M.), Little Rock."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.R.","family":"Morrow","sequence":"additional","affiliation":[{"name":"From Stanford University (D.B., C.C., P.G.), Stanford, Calif; The University of Alabama (D.N., J.K.K.), Birmingham; Columbia University (L.J.A., D.H.), New York, NY; Children\u2019s Hospital Boston and Harvard Medical School (E.D.B.), Boston, Mass; Washington University (C.E.C.), St. Louis, Mo; and The University of Arkansas (W.R.M.), Little Rock."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Pediatric Heart Transplant Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.26.3.240"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)37498-7"},{"key":"e_1_3_2_3_2","first-page":"171","volume":"4","year":"1998","unstructured":"Kurosawa H. 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Incidence and management of dysrhythmias after Fontan procedure. Herz. 1993; 18: 318\u2013327.","journal-title":"Herz"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(03)00342-7"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(98)00130-4"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.08.016"},{"key":"e_1_3_2_16_2","first-page":"713","volume":"16","year":"1997","unstructured":"McGiffin DC, Naftel DC, Kirklin JK, Morrow WR, Towbin J, Shaddy R, Alejos J, Rossi A. Predicting outcome after listing for heart transplantation in children: comparison of Kaplan-Meier and parametric competing risk analysis: Pediatric Heart Transplant Study Group. J Heart Lung Transplant. 1997; 16: 713\u2013722.","journal-title":"J Heart Lung Transplant"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1986.10478314"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(03)00184-0"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(02)01231-7"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2001.005002135.x"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.105.548016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T04:35:00Z","timestamp":1715574900000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.105.548016"}},"subtitle":["A Multi-Institutional Study"],"short-title":[],"issued":{"date-parts":[[2006,7,25]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,7,25]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.105.548016"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.105.548016","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,25]]},"assertion":[{"value":"2006-07-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}