{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:44:58Z","timestamp":1790437498065,"version":"4.1.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2006,1,3]]},"abstract":"<jats:p>Options for the circulatory support of pediatric patients under the age of 5 years are currently limited to short-term extracorporeal devices, the use of which is often complicated by infection, bleeding, and thromboembolism. Recognizing this void, the National Heart, Lung, and Blood Institute solicited proposals for the development of novel circulatory support systems for infants and children from 2 to 25 kg with congenital or acquired cardiovascular disease. Five contracts were awarded to develop a family of devices that includes (1) an implantable mixed-flow ventricular assist device designed specifically for patients up to 2 years of age, (2) another mixed-flow ventricular assist device that can be implanted intravascularly or extravascularly depending on patient size, (3) compact integrated pediatric cardiopulmonary assist systems, (4) apically implanted axial-flow ventricular assist devices, and (5) pulsatile-flow ventricular assist devices. The common objective for these devices is to reliably provide circulatory support for infants and children while minimizing risks related to infection, bleeding, and thromboembolism. The devices are expected to be ready for clinical studies at the conclusion of the awards in 2009.<\/jats:p>","DOI":"10.1161\/circulationaha.105.571422","type":"journal-article","created":{"date-parts":[[2006,1,3]],"date-time":"2006-01-03T21:43:17Z","timestamp":1136324597000},"page":"147-155","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":161,"title":["The National Heart, Lung, and Blood Institute Pediatric Circulatory Support Program"],"prefix":"10.1161","volume":"113","author":[{"given":"J. Timothy","family":"Baldwin","sequence":"first","affiliation":[{"name":"From the Division of Heart and Vascular Diseases, The National Heart, Lung, and Blood Institute (J.T.B., T.R.H.), Bethesda, Md; the Departments of Bioengineering, Surgery, and McGowan Institute for Regenerative Medicine, The University of Pittsburgh (H.S.B.), Pittsburgh, Pa; the Departments of Pediatric and Congenital Heart Surgery and Biomedical Engineering, The Cleveland Clinic Foundation (B.W.D.), Cleveland, Ohio; Ension, Inc (M.J.G.), Pittsburgh, Pa; Jarvik Heart, Inc (R.K.J.), New York, NY; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey S.","family":"Borovetz","sequence":"additional","affiliation":[{"name":"From the Division of Heart and Vascular Diseases, The National Heart, Lung, and Blood Institute (J.T.B., T.R.H.), Bethesda, Md; the Departments of Bioengineering, Surgery, and McGowan Institute for Regenerative Medicine, The University of Pittsburgh (H.S.B.), Pittsburgh, Pa; the Departments of Pediatric and Congenital Heart Surgery and Biomedical Engineering, The Cleveland Clinic Foundation (B.W.D.), Cleveland, Ohio; Ension, Inc (M.J.G.), Pittsburgh, Pa; Jarvik Heart, Inc (R.K.J.), New York, NY; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian W.","family":"Duncan","sequence":"additional","affiliation":[{"name":"From the Division of Heart and Vascular Diseases, The National Heart, Lung, and Blood Institute (J.T.B., T.R.H.), Bethesda, Md; the Departments of Bioengineering, Surgery, and McGowan Institute for Regenerative Medicine, The University of Pittsburgh (H.S.B.), Pittsburgh, Pa; the Departments of Pediatric and Congenital Heart Surgery and Biomedical Engineering, The Cleveland Clinic Foundation (B.W.D.), Cleveland, Ohio; Ension, Inc (M.J.G.), Pittsburgh, Pa; Jarvik Heart, Inc (R.K.J.), New York, NY; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Gartner","sequence":"additional","affiliation":[{"name":"From the Division of Heart and Vascular Diseases, The National Heart, Lung, and Blood Institute (J.T.B., T.R.H.), Bethesda, Md; the Departments of Bioengineering, Surgery, and McGowan Institute for Regenerative Medicine, The University of Pittsburgh (H.S.B.), Pittsburgh, Pa; the Departments of Pediatric and Congenital Heart Surgery and Biomedical Engineering, The Cleveland Clinic Foundation (B.W.D.), Cleveland, Ohio; Ension, Inc (M.J.G.), Pittsburgh, Pa; Jarvik Heart, Inc (R.K.J.), New York, NY; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Jarvik","sequence":"additional","affiliation":[{"name":"From the Division of Heart and Vascular Diseases, The National Heart, Lung, and Blood Institute (J.T.B., T.R.H.), Bethesda, Md; the Departments of Bioengineering, Surgery, and McGowan Institute for Regenerative Medicine, The University of Pittsburgh (H.S.B.), Pittsburgh, Pa; the Departments of Pediatric and Congenital Heart Surgery and Biomedical Engineering, The Cleveland Clinic Foundation (B.W.D.), Cleveland, Ohio; Ension, Inc (M.J.G.), Pittsburgh, Pa; Jarvik Heart, Inc (R.K.J.), New York, NY; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Weiss","sequence":"additional","affiliation":[{"name":"From the Division of Heart and Vascular Diseases, The National Heart, Lung, and Blood Institute (J.T.B., T.R.H.), Bethesda, Md; the Departments of Bioengineering, Surgery, and McGowan Institute for Regenerative Medicine, The University of Pittsburgh (H.S.B.), Pittsburgh, Pa; the Departments of Pediatric and Congenital Heart Surgery and Biomedical Engineering, The Cleveland Clinic Foundation (B.W.D.), Cleveland, Ohio; Ension, Inc (M.J.G.), Pittsburgh, Pa; Jarvik Heart, Inc (R.K.J.), New York, NY; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey R.","family":"Hoke","sequence":"additional","affiliation":[{"name":"From the Division of Heart and Vascular Diseases, The National Heart, Lung, and Blood Institute (J.T.B., T.R.H.), Bethesda, Md; the Departments of Bioengineering, Surgery, and McGowan Institute for Regenerative Medicine, The University of Pittsburgh (H.S.B.), Pittsburgh, Pa; the Departments of Pediatric and Congenital Heart Surgery and Biomedical Engineering, The Cleveland Clinic Foundation (B.W.D.), Cleveland, Ohio; Ension, Inc (M.J.G.), Pittsburgh, Pa; Jarvik Heart, Inc (R.K.J.), New York, NY; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03027-2"},{"key":"e_1_3_3_2_2","first-page":"24","volume":"9","year":"2002","unstructured":"Fuchs A, Netz H. Ventricular assist devices in pediatrics. Images Paediatr Cardiol. 2002; 9: 24\u201354.","journal-title":"Images Paediatr Cardiol"},{"key":"e_1_3_3_3_2","unstructured":"AHA 2005 Statistical Reference Book. Dallas Tex: American Heart Association; 2005."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.103.19.2376"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021715"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2004.06.011"},{"key":"e_1_3_3_7_2","unstructured":"The Organ and Transplantation Procurement Network Web site 2005. Available at: http:\/\/www.optn.org. Accessed May 16 2005."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15015-5"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(95)00238-3"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2003.09.038"},{"key":"e_1_3_3_11_2","unstructured":"Duncan BW. Mechanical circulatory support in infants and children with cardiac disease. In: Zwischenberger JB Bartlett RH eds. ECMO Extracorporeal Cardiopulmonary Support in Critical Care. 2nd ed. Ann Arbor Mich: Extracorporeal Life Support Organization; 2000."},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.115243"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2004.05.059"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00410-M"},{"key":"e_1_3_3_15_2","first-page":"1172","volume":"17","year":"1998","unstructured":"Sidiropoulos A, Hotz H, Konertz W. Pediatric circulatory support. J Heart Lung Transplant. 1998; 17: 1172\u20131176.","journal-title":"J Heart Lung Transplant"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70333-8"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002480-200205000-00003"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002480-199507000-00011"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(99)00116-3"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(00)70142-5"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)00246-5"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.101.4.356"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)02614-X"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)02639-4"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2004.12.117"},{"key":"e_1_3_3_26_2","unstructured":"ECLS Registry Report. Ann Arbor Mich: Extracorporeal Life Support Organization; January 2005."},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MAT.0000151922.67540.E9"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000149233.45740.AA"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)00914-X"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1092-9126(99)70017-7"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.82.2.237"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2005.29082.x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2005.29088.x"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1159\/000075991"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.1987.tb02666.x"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00991-4"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/088532820001400403"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.105.571422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T04:37:19Z","timestamp":1715575039000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.105.571422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,3]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1,3]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.105.571422"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.105.571422","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,3]]},"assertion":[{"value":"2006-01-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}