{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:59:02Z","timestamp":1788760742586,"version":"build-2803163510"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"25","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2006,6,27]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Delivery of inappropriate shocks caused by misdetection of supraventricular tachycardia (SVT) remains a substantial complication of implanted cardioverter\/defibrillator (ICD) therapy. Whether use of optimally programmed dual-chamber ICDs lowers this risk compared with that in single-chamber ICDs is not clear.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Subjects with a clinical indication for ICD (n=400) at 27 participating centers received dual-chamber ICDs and were randomly assigned to strictly defined optimal single- or dual-chamber detection in a single-blind manner. Programming minimized ventricular pacing. The primary end point was the proportion of SVT episodes inappropriately detected from the time of programming until crossover or end of study. On a per-episode basis, 42% of the episodes in the single-chamber arm and 69% of the episodes in the dual-chamber arm were due to SVT. Mortality (3.5% in both groups) and early study withdrawal (14% single-chamber, 11% dual-chamber) were similar in both groups. The rate of inappropriate detection of SVT was 39.5% in the single-chamber detection arm compared with 30.9% in the dual-chamber arm. The odds of inappropriate detection were decreased by almost half with the use of the dual-chamber detection enhancements (odds ratio, 0.53; 95% confidence interval, 0.30 to 0.94;\n            <jats:italic>P<\/jats:italic>\n            =0.03).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Dual-chamber ICDs, programmed to optimize detection enhancements and to minimize ventricular pacing, significantly decrease inappropriate detection.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.105.594531","type":"journal-article","created":{"date-parts":[[2006,6,13]],"date-time":"2006-06-13T01:05:11Z","timestamp":1150160711000},"page":"2871-2879","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":223,"title":["Dual-Chamber Versus Single-Chamber Detection Enhancements for Implantable Defibrillator Rhythm Diagnosis"],"prefix":"10.1161","volume":"113","author":[{"given":"Paul A.","family":"Friedman","sequence":"first","affiliation":[{"name":"From the Division of Cardiovascular Diseases (P.A.F., T.M.M.) and the Division of Biostatistics (R.L.M., W.R.B.), Mayo Clinic, Rochester, Minn; Electrophysiology, Trinity Medical Center, Rock Island, Ill (H.A.); Electrophysiology and Cardiac Pacing, Austin Heart, Austin, Tex (D.K.); Cardiology\/Electrophysiology, Watson Clinic, Lakeland, Fla (N.G.K.); Internal Medicine\/Cardiology, Virginia Commonwealth University, Richmond (M.W.); Cardiovascular Disease, MidWest Research Foundation, Riverside..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn L.","family":"McClelland","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases (P.A.F., T.M.M.) and the Division of Biostatistics (R.L.M., W.R.B.), Mayo Clinic, Rochester, Minn; Electrophysiology, Trinity Medical Center, Rock Island, Ill (H.A.); Electrophysiology and Cardiac Pacing, Austin Heart, Austin, Tex (D.K.); Cardiology\/Electrophysiology, Watson Clinic, Lakeland, Fla (N.G.K.); Internal Medicine\/Cardiology, Virginia Commonwealth University, Richmond (M.W.); Cardiovascular Disease, MidWest Research Foundation, Riverside..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Bamlet","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases (P.A.F., T.M.M.) and the Division of Biostatistics (R.L.M., W.R.B.), Mayo Clinic, Rochester, Minn; Electrophysiology, Trinity Medical Center, Rock Island, Ill (H.A.); Electrophysiology and Cardiac Pacing, Austin Heart, Austin, Tex (D.K.); Cardiology\/Electrophysiology, Watson Clinic, Lakeland, Fla (N.G.K.); Internal Medicine\/Cardiology, Virginia Commonwealth University, Richmond (M.W.); Cardiovascular Disease, MidWest Research Foundation, Riverside..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helbert","family":"Acosta","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases (P.A.F., T.M.M.) and the Division of Biostatistics (R.L.M., W.R.B.), Mayo Clinic, Rochester, Minn; Electrophysiology, Trinity Medical Center, Rock Island, Ill (H.A.); Electrophysiology and Cardiac Pacing, Austin Heart, Austin, Tex (D.K.); Cardiology\/Electrophysiology, Watson Clinic, Lakeland, Fla (N.G.K.); Internal Medicine\/Cardiology, Virginia Commonwealth University, Richmond (M.W.); Cardiovascular Disease, MidWest Research Foundation, Riverside..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kessler","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases (P.A.F., T.M.M.) and the Division of Biostatistics (R.L.M., W.R.B.), Mayo Clinic, Rochester, Minn; Electrophysiology, Trinity Medical Center, Rock Island, Ill (H.A.); Electrophysiology and Cardiac Pacing, Austin Heart, Austin, Tex (D.K.); Cardiology\/Electrophysiology, Watson Clinic, Lakeland, Fla (N.G.K.); Internal Medicine\/Cardiology, Virginia Commonwealth University, Richmond (M.W.); Cardiovascular Disease, MidWest Research Foundation, Riverside..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Munger","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases (P.A.F., T.M.M.) and the Division of Biostatistics (R.L.M., W.R.B.), Mayo Clinic, Rochester, Minn; Electrophysiology, Trinity Medical Center, Rock Island, Ill (H.A.); Electrophysiology and Cardiac Pacing, Austin Heart, Austin, Tex (D.K.); Cardiology\/Electrophysiology, Watson Clinic, Lakeland, Fla (N.G.K.); Internal Medicine\/Cardiology, Virginia Commonwealth University, Richmond (M.W.); Cardiovascular Disease, MidWest Research Foundation, Riverside..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal G.","family":"Kavesh","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases (P.A.F., T.M.M.) and the Division of Biostatistics (R.L.M., W.R.B.), Mayo Clinic, Rochester, Minn; Electrophysiology, Trinity Medical Center, Rock Island, Ill (H.A.); Electrophysiology and Cardiac Pacing, Austin Heart, Austin, Tex (D.K.); Cardiology\/Electrophysiology, Watson Clinic, Lakeland, Fla (N.G.K.); Internal Medicine\/Cardiology, Virginia Commonwealth University, Richmond (M.W.); Cardiovascular Disease, MidWest Research Foundation, Riverside..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Wood","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases (P.A.F., T.M.M.) and the Division of Biostatistics (R.L.M., W.R.B.), Mayo Clinic, Rochester, Minn; Electrophysiology, Trinity Medical Center, Rock Island, Ill (H.A.); Electrophysiology and Cardiac Pacing, Austin Heart, Austin, Tex (D.K.); Cardiology\/Electrophysiology, Watson Clinic, Lakeland, Fla (N.G.K.); Internal Medicine\/Cardiology, Virginia Commonwealth University, Richmond (M.W.); Cardiovascular Disease, MidWest Research Foundation, Riverside..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emile","family":"Daoud","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases (P.A.F., T.M.M.) and the Division of Biostatistics (R.L.M., W.R.B.), Mayo Clinic, Rochester, Minn; Electrophysiology, Trinity Medical Center, Rock Island, Ill (H.A.); Electrophysiology and Cardiac Pacing, Austin Heart, Austin, Tex (D.K.); Cardiology\/Electrophysiology, Watson Clinic, Lakeland, Fla (N.G.K.); Internal Medicine\/Cardiology, Virginia Commonwealth University, Richmond (M.W.); Cardiovascular Disease, MidWest Research Foundation, Riverside..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Massumi","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases (P.A.F., T.M.M.) and the Division of Biostatistics (R.L.M., W.R.B.), Mayo Clinic, Rochester, Minn; Electrophysiology, Trinity Medical Center, Rock Island, Ill (H.A.); Electrophysiology and Cardiac Pacing, Austin Heart, Austin, Tex (D.K.); Cardiology\/Electrophysiology, Watson Clinic, Lakeland, Fla (N.G.K.); Internal Medicine\/Cardiology, Virginia Commonwealth University, Richmond (M.W.); Cardiovascular Disease, MidWest Research Foundation, Riverside..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Schuger","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases (P.A.F., T.M.M.) and the Division of Biostatistics (R.L.M., W.R.B.), Mayo Clinic, Rochester, Minn; Electrophysiology, Trinity Medical Center, Rock Island, Ill (H.A.); Electrophysiology and Cardiac Pacing, Austin Heart, Austin, Tex (D.K.); Cardiology\/Electrophysiology, Watson Clinic, Lakeland, Fla (N.G.K.); Internal Medicine\/Cardiology, Virginia Commonwealth University, Richmond (M.W.); Cardiovascular Disease, MidWest Research Foundation, Riverside..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Shorofsky","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases (P.A.F., T.M.M.) and the Division of Biostatistics (R.L.M., W.R.B.), Mayo Clinic, Rochester, Minn; Electrophysiology, Trinity Medical Center, Rock Island, Ill (H.A.); Electrophysiology and Cardiac Pacing, Austin Heart, Austin, Tex (D.K.); Cardiology\/Electrophysiology, Watson Clinic, Lakeland, Fla (N.G.K.); Internal Medicine\/Cardiology, Virginia Commonwealth University, Richmond (M.W.); Cardiovascular Disease, MidWest Research Foundation, Riverside..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Wilkoff","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases (P.A.F., T.M.M.) and the Division of Biostatistics (R.L.M., W.R.B.), Mayo Clinic, Rochester, Minn; Electrophysiology, Trinity Medical Center, Rock Island, Ill (H.A.); Electrophysiology and Cardiac Pacing, Austin Heart, Austin, Tex (D.K.); Cardiology\/Electrophysiology, Watson Clinic, Lakeland, Fla (N.G.K.); Internal Medicine\/Cardiology, Virginia Commonwealth University, Richmond (M.W.); Cardiovascular Disease, MidWest Research Foundation, Riverside..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Glikson","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases (P.A.F., T.M.M.) and the Division of Biostatistics (R.L.M., W.R.B.), Mayo Clinic, Rochester, Minn; Electrophysiology, Trinity Medical Center, Rock Island, Ill (H.A.); Electrophysiology and Cardiac Pacing, Austin Heart, Austin, Tex (D.K.); Cardiology\/Electrophysiology, Watson Clinic, Lakeland, Fla (N.G.K.); Internal Medicine\/Cardiology, Virginia Commonwealth University, Richmond (M.W.); Cardiovascular Disease, MidWest Research Foundation, Riverside..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013474"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043399"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1999.tb01261.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.00134.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.039"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1992.tb02953.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1994.tb01391.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.09.017"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.105.5.589"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.24.3115"},{"key":"e_1_3_2_11_2","unstructured":"Centers for Medicare & Medicaid Services. Coverage determinations: implantable automatic defibrillators. In: Medicare National Coverage Determinations Manual. Baltimore Md. CMS-Pub 100-3; Pt 1 section 20.4 [cited 2005 Jul 20]. Available at: http:\/\/www.cms.hhs.gov\/mcd\/viewncd.asp?ncd_id=20.4&ncd_version=3&basket=ncd%3A20%2E4%3A3%3AImplantable+Automatic+Defibrillators. 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EMPIRIC study. Paper presented at: Heart Rhythm 2005 Scientific Sessions; May 4\u20137 2005; New Orleans La."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000072769.17295.b1"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.105.594531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T05:05:20Z","timestamp":1715576720000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.105.594531"}},"subtitle":["The Detect Supraventricular Tachycardia Study"],"short-title":[],"issued":{"date-parts":[[2006,6,27]]},"references-count":23,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2006,6,27]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.105.594531"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.105.594531","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,27]]},"assertion":[{"value":"2006-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}