{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:40:10Z","timestamp":1790617210884,"version":"4.1.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2006,8,15]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            An association between orthostatic hypotension (OH) and mortality has been reported, but studies are limited to older adults or high-risk populations.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            We investigated the association between OH (a decrease of 20 mm Hg in systolic blood pressure or a decrease of 10 mm Hg in diastolic blood pressure on standing) and 13-year mortality among middle-aged black and white men and women from the Atherosclerosis Risk in Communities Study (1987\u20131989). At baseline, 674 participants (5%) had OH. All-cause mortality was higher among those with (13.7%) than without (4.2%) OH. After we controlled for ethnicity, gender, and age, the hazard ratio (HR) for OH for all-cause mortality was 2.4 (95% confidence interval [CI], 2.1 to 2.8). Adjustment for risk factors for cardiovascular disease and mortality and selected health conditions at baseline attenuated but did not completely explain this association (HR=1.7; 95% CI, 1.4 to 2.0). This association persisted among subsets that (1) excluded those who died within the first 2 years of follow-up and (2) were limited to those without coronary heart disease, cancer, stroke, diabetes, hypertension, or fair\/poor perceived health status at baseline. In analyses by causes of death, a significant increased hazard of death among those with versus without OH persisted after adjustment for risk factors for cardiovascular disease (HR=2.0; 95% CI, 1.6 to 2.7) and other deaths (HR=2.1; 95% CI, 1.6 to 2.8) but not for cancer (odds ratio=1.1; 95% CI, 0.8 to 1.6).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            OH predicts mortality in middle-aged adults. This association is only partly explained by traditional risk factors for cardiovascular disease and overall mortality.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.105.598722","type":"journal-article","created":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T00:39:20Z","timestamp":1154997560000},"page":"630-636","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":249,"title":["Orthostatic Hypotension Predicts Mortality in Middle-Aged Adults"],"prefix":"10.1161","volume":"114","author":[{"given":"Kathryn M.","family":"Rose","sequence":"first","affiliation":[{"name":"From the Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill (K.M.R., G.H.); Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock (M.L.E.); Ross Products Division, Abbott Laboratories, Columbus, Ohio (R.L.B.); Collaborative Studies Coordinating Center, Department of Biostatistics, School of Public Health, University of North Carolina at Chapel Hill (D.J.C.); Department of Psychiatry,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marsha L.","family":"Eigenbrodt","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill (K.M.R., G.H.); Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock (M.L.E.); Ross Products Division, Abbott Laboratories, Columbus, Ohio (R.L.B.); Collaborative Studies Coordinating Center, Department of Biostatistics, School of Public Health, University of North Carolina at Chapel Hill (D.J.C.); Department of Psychiatry,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Biga","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill (K.M.R., G.H.); Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock (M.L.E.); Ross Products Division, Abbott Laboratories, Columbus, Ohio (R.L.B.); Collaborative Studies Coordinating Center, Department of Biostatistics, School of Public Health, University of North Carolina at Chapel Hill (D.J.C.); Department of Psychiatry,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Couper","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill (K.M.R., G.H.); Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock (M.L.E.); Ross Products Division, Abbott Laboratories, Columbus, Ohio (R.L.B.); Collaborative Studies Coordinating Center, Department of Biostatistics, School of Public Health, University of North Carolina at Chapel Hill (D.J.C.); Department of Psychiatry,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen C.","family":"Light","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill (K.M.R., G.H.); Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock (M.L.E.); Ross Products Division, Abbott Laboratories, Columbus, Ohio (R.L.B.); Collaborative Studies Coordinating Center, Department of Biostatistics, School of Public Health, University of North Carolina at Chapel Hill (D.J.C.); Department of Psychiatry,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Richey","family":"Sharrett","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill (K.M.R., G.H.); Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock (M.L.E.); Ross Products Division, Abbott Laboratories, Columbus, Ohio (R.L.B.); Collaborative Studies Coordinating Center, Department of Biostatistics, School of Public Health, University of North Carolina at Chapel Hill (D.J.C.); Department of Psychiatry,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Heiss","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill (K.M.R., G.H.); Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock (M.L.E.); Ross Products Division, Abbott Laboratories, Columbus, Ohio (R.L.B.); Collaborative Studies Coordinating Center, Department of Biostatistics, School of Public Health, University of North Carolina at Chapel Hill (D.J.C.); Department of Psychiatry,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0511(94)00958-Z"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1994.tb04977.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012170"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060143"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.33.5.1123"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.5.1470"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.105.8.956"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(99)00257-5"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb02869.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb03593.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.19.6.508"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001732"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.75.2.3802437"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01313.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001482"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.31.10.2307"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.98.21.2290"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.3.273"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh614"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2004.06.009"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1995.00430090067008"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(95)00047-X"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115184"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331979204300703"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/36.5.936"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/jon199114168"},{"key":"e_1_3_2_27_2","unstructured":"National Heart Lung and Blood Institute. 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