{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T08:37:20Z","timestamp":1768984640284,"version":"3.49.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2006,6,6]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            The safety of aspirin in heart failure (HF) has been called into question, particularly in those patients (1) without coronary disease, (2) with renal dysfunction, or (3) treated with low-dose angiotensin-converting enzyme (ACE) inhibitors and high-dose aspirin.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            We examined prescription patterns and outcomes (all-cause mortality and\/or HF readmission) in patients discharged from 103 Canadian hospitals between April 1999 and March 2001 after a first hospitalization for HF. Of 7352 patients with HF (mean age, 75 years; 44% without coronary disease and 29% with renal dysfunction), 2785 (38%) died or required HF readmission within the first year. Compared with nonusers, aspirin users were no more likely to die or require HF readmission (hazard ratio [HR], 1.02 [0.91 to 1.16]), even in patients without coronary disease (HR, 0.98 [0.78 to 1.22]) or patients with renal dysfunction (HR, 1.13 [0.94 to 1.36]). On the other hand, users of ACE inhibitors were less likely to die or require HF readmission (HR, 0.87 [0.79 to 0.96]), even if they were using aspirin (HR, 0.86 [0.77 to 0.95]). There were no dose-dependent interactions between aspirin and ACE inhibitors.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            In this observational study, aspirin use was not associated with an increase in mortality rates or HF readmission rates, and aspirin did not attenuate the benefits of ACE inhibitors, even in patients without coronary disease, patients with renal dysfunction, or patients treated with high-dose aspirin and low-dose ACE inhibitors.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.105.602136","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T09:09:16Z","timestamp":1149066556000},"page":"2572-2578","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Aspirin Use and Outcomes in a Community-Based Cohort of 7352 Patients Discharged After First Hospitalization for Heart Failure"],"prefix":"10.1161","volume":"113","author":[{"given":"Finlay A.","family":"McAlister","sequence":"first","affiliation":[{"name":"From the Division of General Internal Medicine (F.A.M.) and the Division of Cardiology (P.W.A.), University of Alberta, Edmonton, Canada; the Division of General Internal Medicine, University of Calgary, Calgary, Canada (W.A.G.); the Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Canada (Y.G., J.F.); and the Division of General Internal Medicine, Sunnybrook and Women\u2019s College Health Sciences Centre, University of Toronto, Toronto, Canada (J.V.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Ghali","sequence":"additional","affiliation":[{"name":"From the Division of General Internal Medicine (F.A.M.) and the Division of Cardiology (P.W.A.), University of Alberta, Edmonton, Canada; the Division of General Internal Medicine, University of Calgary, Calgary, Canada (W.A.G.); the Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Canada (Y.G., J.F.); and the Division of General Internal Medicine, Sunnybrook and Women\u2019s College Health Sciences Centre, University of Toronto, Toronto, Canada (J.V.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Gong","sequence":"additional","affiliation":[{"name":"From the Division of General Internal Medicine (F.A.M.) and the Division of Cardiology (P.W.A.), University of Alberta, Edmonton, Canada; the Division of General Internal Medicine, University of Calgary, Calgary, Canada (W.A.G.); the Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Canada (Y.G., J.F.); and the Division of General Internal Medicine, Sunnybrook and Women\u2019s College Health Sciences Centre, University of Toronto, Toronto, Canada (J.V.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiming","family":"Fang","sequence":"additional","affiliation":[{"name":"From the Division of General Internal Medicine (F.A.M.) and the Division of Cardiology (P.W.A.), University of Alberta, Edmonton, Canada; the Division of General Internal Medicine, University of Calgary, Calgary, Canada (W.A.G.); the Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Canada (Y.G., J.F.); and the Division of General Internal Medicine, Sunnybrook and Women\u2019s College Health Sciences Centre, University of Toronto, Toronto, Canada (J.V.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul W.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"From the Division of General Internal Medicine (F.A.M.) and the Division of Cardiology (P.W.A.), University of Alberta, Edmonton, Canada; the Division of General Internal Medicine, University of Calgary, Calgary, Canada (W.A.G.); the Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Canada (Y.G., J.F.); and the Division of General Internal Medicine, Sunnybrook and Women\u2019s College Health Sciences Centre, University of Toronto, Toronto, Canada (J.V.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack V.","family":"Tu","sequence":"additional","affiliation":[{"name":"From the Division of General Internal Medicine (F.A.M.) and the Division of Cardiology (P.W.A.), University of Alberta, Edmonton, Canada; the Division of General Internal Medicine, University of Calgary, Calgary, Canada (W.A.G.); the Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Canada (Y.G., J.F.); and the Division of General Internal Medicine, Sunnybrook and Women\u2019s College Health Sciences Centre, University of Toronto, Toronto, Canada (J.V.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","unstructured":"Hunt SA Baker DW Chin MH Cinquegrani MP Feldman AM Francis GS Ganiats TG Goldstein S Gregoratos G Jessup ML Noble RJ Packer M Silver MA Stevenson LW. ACC\/AHA guidelines for the evaluation and management of chronic heart failure in the adult: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure). 2001. American College of Cardiology Web site. Available at: http:\/\/www.acc.org\/clinical\/guidelines\/failure\/hf_index.htm. Accessed May 19 2006."},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.3_suppl.513S"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.10.082"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/pcad.2002.31597"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.07.062"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7329.71"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.03.010"},{"key":"e_1_3_2_8_2","unstructured":"Massie BM. What\u2019s the best antithrombotic in chronic HF? Presented at 2004 American College of Cardiology Meeting March 10 2004. Available at: http:\/\/www.theheart.org\/viewArticle.do?primaryKey=221355. 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