{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:32:59Z","timestamp":1788881579386,"version":"build-2803163510"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2006,8,29]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Coronary angiography is one of the most frequently performed procedures in women; however, nonobstructive (ie, &lt;50% stenosis) coronary artery disease (CAD) is frequently reported. Few data exist regarding the type and intensity of resource consumption in women with chest pain after coronary angiography.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            A total of 883 women referred for coronary angiography were prospectively enrolled in the National Institutes of Health\u2013National Heart, Lung, and Blood Institute\u2013sponsored Women\u2019s Ischemia Syndrome Evaluation (WISE). Cardiovascular prognosis and cost data were collected. Direct (hospitalizations, office visits, procedures, and drug utilization) and indirect (out-of-pocket, lost productivity, and travel) costs were estimated through 5 years of follow-up. Among 883 women, 62%, 17%, 11%, and 10% had nonobstructive and 1-vessel, 2-vessel, and 3-vessel CAD, respectively. Five-year cardiovascular death or myocardial infarction rates ranged from 4% to 38% for women with nonobstructive to 3-vessel CAD (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001). Five-year rates of hospitalization for chest pain occurred in 20% of women with nonobstructive CAD, increasing to 38% to 55% for women with 1-vessel to 3-vessel CAD (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001). The volume of repeat catheterizations or angina hospitalizations was 1.8-fold higher in women with nonobstructive versus 1-vessel CAD after 1 year of follow-up (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001). Drug treatment was highest for those with nonobstructive or 1-vessel CAD (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001). The proportion of costs for anti-ischemic therapy was higher for women with nonobstructive CAD (15% versus 12% for 1-vessel to 3-vessel CAD;\n            <jats:italic>P<\/jats:italic>\n            =0.001). For women with nonobstructive CAD, average lifetime cost estimates were $767 288 (95% CI, $708 480 to $826 097) and ranged from $1 001 493 to $1 051 302 for women with 1-vessel to 3-vessel CAD (\n            <jats:italic>P<\/jats:italic>\n            =0.0003).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Symptom-driven care is costly even for women with nonobstructive CAD. Our lifetime estimates for costs of cardiovascular care identify a significant subset of women who are unaccounted for within current estimates of the economic burden of coronary heart disease.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.105.609990","type":"journal-article","created":{"date-parts":[[2006,8,22]],"date-time":"2006-08-22T00:13:41Z","timestamp":1156205621000},"page":"894-904","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":314,"title":["The Economic Burden of Angina in Women With Suspected Ischemic Heart Disease"],"prefix":"10.1161","volume":"114","author":[{"given":"Leslee J.","family":"Shaw","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (L.J.S., C.N.B.M.); Division of Cardiology, Department of Medicine, University of Florida, Gainesville (C.J.P.); Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa (S.E.R.); Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa (K.E.K., S.F.K., M.O., B.D.J.); Division of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Noel Bairey","family":"Merz","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (L.J.S., C.N.B.M.); Division of Cardiology, Department of Medicine, University of Florida, Gainesville (C.J.P.); Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa (S.E.R.); Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa (K.E.K., S.F.K., M.O., B.D.J.); Division of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J.","family":"Pepine","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (L.J.S., C.N.B.M.); Division of Cardiology, Department of Medicine, University of Florida, Gainesville (C.J.P.); Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa (S.E.R.); Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa (K.E.K., S.F.K., M.O., B.D.J.); Division of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Reis","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (L.J.S., C.N.B.M.); Division of Cardiology, Department of Medicine, University of Florida, Gainesville (C.J.P.); Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa (S.E.R.); Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa (K.E.K., S.F.K., M.O., B.D.J.); Division of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Bittner","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (L.J.S., C.N.B.M.); Division of Cardiology, Department of Medicine, University of Florida, Gainesville (C.J.P.); Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa (S.E.R.); Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa (K.E.K., S.F.K., M.O., B.D.J.); Division of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin E.","family":"Kip","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (L.J.S., C.N.B.M.); Division of Cardiology, Department of Medicine, University of Florida, Gainesville (C.J.P.); Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa (S.E.R.); Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa (K.E.K., S.F.K., M.O., B.D.J.); Division of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl F.","family":"Kelsey","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (L.J.S., C.N.B.M.); Division of Cardiology, Department of Medicine, University of Florida, Gainesville (C.J.P.); Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa (S.E.R.); Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa (K.E.K., S.F.K., M.O., B.D.J.); Division of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Olson","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (L.J.S., C.N.B.M.); Division of Cardiology, Department of Medicine, University of Florida, Gainesville (C.J.P.); Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa (S.E.R.); Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa (K.E.K., S.F.K., M.O., B.D.J.); Division of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Delia","family":"Johnson","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (L.J.S., C.N.B.M.); Division of Cardiology, Department of Medicine, University of Florida, Gainesville (C.J.P.); Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa (S.E.R.); Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa (K.E.K., S.F.K., M.O., B.D.J.); Division of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Mankad","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (L.J.S., C.N.B.M.); Division of Cardiology, Department of Medicine, University of Florida, Gainesville (C.J.P.); Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa (S.E.R.); Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa (K.E.K., S.F.K., M.O., B.D.J.); Division of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry L.","family":"Sharaf","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (L.J.S., C.N.B.M.); Division of Cardiology, Department of Medicine, University of Florida, Gainesville (C.J.P.); Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa (S.E.R.); Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa (K.E.K., S.F.K., M.O., B.D.J.); Division of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Rogers","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (L.J.S., C.N.B.M.); Division of Cardiology, Department of Medicine, University of Florida, Gainesville (C.J.P.); Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa (S.E.R.); Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa (K.E.K., S.F.K., M.O., B.D.J.); Division of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald M.","family":"Pohost","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (L.J.S., C.N.B.M.); Division of Cardiology, Department of Medicine, University of Florida, Gainesville (C.J.P.); Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa (S.E.R.); Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa (K.E.K., S.F.K., M.O., B.D.J.); Division of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Sopko","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (L.J.S., C.N.B.M.); Division of Cardiology, Department of Medicine, University of Florida, Gainesville (C.J.P.); Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pa (S.E.R.); Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa (K.E.K., S.F.K., M.O., B.D.J.); Division of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","unstructured":"Merrill CT Elixhauser A. 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