{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T08:51:02Z","timestamp":1793436662380,"version":"4.5.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            The causes of aortic regurgitation (AR) severe enough to warrant aortic valve replacement (AVR) have received little attention in the last 20 years.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            We analyzed the causes of pure AR in 268 patients &gt;20 years of age having isolated AVR at Baylor University Medical Center from 1993 to 2005 that was unassociated with mitral stenosis, mitral valve replacement, or a previous operation involving a cardiac valve or ascending aorta. In 122 patients (46%), the AR resulted from a problem with the aortic valve: congenital malformation unassociated with infective endocarditis, 66 patients (54%); infective endocarditis, 46 patients (38%; 15 with bicuspid valves); probable rheumatic heart disease, 8 patients (6%); and miscellaneous, 2 patients (2%). In the other 146 patients (54%), the AR was the consequence of a condition affecting the ascending aorta: dissection, 28 patients (19%); the Marfan syndrome or its forme fruste variety, 15 patients (10%); aortitis, 12 patients (8%), and in the remaining 91 patients (62%), the cause of the AR was not determined. This latter group was the oldest (mean age 66 years), 83 (91%) had hypertension, 26 (29%) had small calcific deposits in the valve cusps, and 46 (51%) had simultaneous coronary artery bypass grafting.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            The causes of pure AR severe enough to warrant isolated AVR are diverse. The most common category in this study was \u201ccause unclear.\u201d\n          <\/jats:p>","DOI":"10.1161\/circulationaha.106.622761","type":"journal-article","created":{"date-parts":[[2006,7,25]],"date-time":"2006-07-25T00:25:41Z","timestamp":1153787141000},"page":"422-429","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":109,"title":["Causes of Pure Aortic Regurgitation in Patients Having Isolated Aortic Valve Replacement at a Single US Tertiary Hospital (1993 to 2005)"],"prefix":"10.1161","volume":"114","author":[{"given":"William Clifford","family":"Roberts","sequence":"first","affiliation":[{"name":"From the Departments of Pathology and Medicine (Division of Cardiology), Baylor Heart &amp; Vascular Institute (W.C.R., J.M.K.), Baylor University Medical Center, Dallas, Tex; Heart Center, Brownwood Regional Medical Center (T.R.M.), Brownwood, Tex; and Cardiology Association of North Mississippi (W.H.J.), Tupelo, Miss."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Mi","family":"Ko","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Medicine (Division of Cardiology), Baylor Heart &amp; Vascular Institute (W.C.R., J.M.K.), Baylor University Medical Center, Dallas, Tex; Heart Center, Brownwood Regional Medical Center (T.R.M.), Brownwood, Tex; and Cardiology Association of North Mississippi (W.H.J.), Tupelo, Miss."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy Richard","family":"Moore","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Medicine (Division of Cardiology), Baylor Heart &amp; Vascular Institute (W.C.R., J.M.K.), Baylor University Medical Center, Dallas, Tex; Heart Center, Brownwood Regional Medical Center (T.R.M.), Brownwood, Tex; and Cardiology Association of North Mississippi (W.H.J.), Tupelo, Miss."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"William Hampton","family":"Jones","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Medicine (Division of Cardiology), Baylor Heart &amp; Vascular Institute (W.C.R., J.M.K.), Baylor University Medical Center, Dallas, Tex; Heart Center, Brownwood Regional Medical Center (T.R.M.), Brownwood, Tex; and Cardiology Association of North Mississippi (W.H.J.), Tupelo, Miss."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.07.018"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000155623.48408.c5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.543280"},{"key":"e_1_3_2_4_2","unstructured":"Roberts WC. Morphological features of the elderly heart. In: Tresch D Aronow WS. 2nd ed. Cardiovascular Disease in the Elderly Patient. New York NY: Marcel Dekker; 1999: 17\u201342."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(82)90527-6"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.22.4.505"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(81)90385-4"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)65618-3"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(85)90393-5"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.106.622761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T05:12:42Z","timestamp":1715577162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.106.622761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.106.622761"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.106.622761","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"2006-07-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}