{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:02:42Z","timestamp":1788973362489,"version":"build-2803163510"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2006,12,12]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>Background\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Systematic use of coronary stents and optimized platelet aggregation inhibition has greatly improved the short-term results of percutaneous coronary interventions. Transradial percutaneous coronary interventions have been associated with a low risk of bleeding complications. It is unknown whether moderate- and high-risk patients can be discharged safely the same day after uncomplicated transradial percutaneous coronary interventions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods and Results\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    We randomized 1005 patients after a bolus of abciximab and uncomplicated transradial percutaneous coronary stent implantation either to same-day home discharge and no infusion of abciximab (group 1, n=504) or to overnight hospitalization and a standard 12-hour infusion of abciximab (group 2, n=501). The primary composite end point of the study was the 30-day incidence of any of the following events: death, myocardial infarction, urgent revascularization, major bleeding, repeat hospitalization, access site complications, and severe thrombocytopenia. The noninferiority of same-day home discharge and bolus of abciximab only compared with overnight hospitalization and abciximab bolus and infusion was evaluated. Two thirds of patients presented with unstable angina and \u224820% presented with high-risk acute coronary syndrome prior to the procedure. The incidence of the primary end point was 20.4% in group 1 and 18.2% in group 2 (\n                    <jats:italic>P<\/jats:italic>\n                    =0.017 for noninferiority) with a troponin T\u2013based definition of myocardial infarction; the incidence of the primary end point was 11.1% in group 1 and 9.6% in group 2 (\n                    <jats:italic>P<\/jats:italic>\n                    =0.0004 for noninferiority) with a creatinine kinase myocardial band\u2013based definition of myocardial infarction. No death occurred. Rate of major bleeding in both groups was extremely low at 0.8% and 0.2%, respectively. From 504 patients randomized in group 1, 88% were discharged home the same day.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusion\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Our data suggest that same-day home discharge after uncomplicated transradial coronary stenting and bolus only of abciximab is not clinically inferior, in a wide spectrum of patients, to the standard overnight hospitalization and a bolus followed by a 12-hour infusion. This novel approach offers a safe strategy for same-day home discharge after uncomplicated coronary intervention.\n                  <\/jats:p>","DOI":"10.1161\/circulationaha.106.638627","type":"journal-article","created":{"date-parts":[[2006,12,4]],"date-time":"2006-12-04T20:34:44Z","timestamp":1165264484000},"page":"2636-2643","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":292,"title":["A Randomized Study Comparing Same-Day Home Discharge and Abciximab Bolus Only to Overnight Hospitalization and Abciximab Bolus and Infusion After Transradial Coronary Stent Implantation"],"prefix":"10.1161","volume":"114","author":[{"given":"Olivier F.","family":"Bertrand","sequence":"first","affiliation":[{"name":"From the Ho\u0302pital Laval, Institut Universitaire de Cardiologie et de Pneumologie, affilie\u0301 a\u0300 l\u2019Universite\u0301 Laval, Que\u0301bec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"De Larochellie\u0300re","sequence":"additional","affiliation":[{"name":"From the Ho\u0302pital Laval, Institut Universitaire de Cardiologie et de Pneumologie, affilie\u0301 a\u0300 l\u2019Universite\u0301 Laval, Que\u0301bec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Rode\u0301s-Cabau","sequence":"additional","affiliation":[{"name":"From the Ho\u0302pital Laval, Institut Universitaire de Cardiologie et de Pneumologie, affilie\u0301 a\u0300 l\u2019Universite\u0301 Laval, Que\u0301bec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Proulx","sequence":"additional","affiliation":[{"name":"From the Ho\u0302pital Laval, Institut Universitaire de Cardiologie et de Pneumologie, affilie\u0301 a\u0300 l\u2019Universite\u0301 Laval, Que\u0301bec, 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