{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:57:57Z","timestamp":1791806277465,"version":"4.3.4"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2006,11,21]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>Background\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Nonobstructive hypertrophic cardiomyopathy (HCM) has been regarded as the predominant hemodynamic form of the disease on the basis of assessment of outflow gradient under resting conditions. We sought to prospectively define the prevalence, clinical profile, and significance of left ventricular (LV) outflow tract obstruction under resting conditions and with physiological exercise in a large HCM cohort.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods and Results\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    We prospectively analyzed 320 consecutive HCM patients (age, 47\u00b117 years), measuring LV outflow gradient at rest, with Valsalva maneuver, and with exercise echocardiography. LV outflow obstruction was present at rest and\/or with exercise in 225 patients (70%); 119 had rest gradients \u226550 mm Hg and were not exercised. Of the other 201 patients with gradients &lt;50 mm Hg at rest (average, 4\u00b19 mm Hg), 106 developed mechanical obstruction to LV outflow resulting from mitral valve\u2013septal contact after exercise (80\u00b143 mm Hg), including 76 with marked gradients \u226550 mm Hg and 46 with heart failure symptoms. The remaining 95 patients (30%) had no or small gradients (&lt;30 mm Hg) both at rest and with exercise. Valsalva maneuver underestimated the presence and magnitude of exercise-induced obstruction.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusions\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Among those patients who come to clinical evaluation, HCM is a predominantly obstructive disease in which LV outflow gradients, frequently associated with heart failure symptoms and often identified only with exercise, are evident in most patients (ie, 70%). Identification of LV outflow obstruction with exercise echocardiography may broaden management options in HCM by identifying symptomatic patients not otherwise regarded as potential candidates for septal reduction therapy. Assessment of subaortic gradients with exercise should be a routine component of the evaluation of HCM patients without outflow obstruction under resting conditions.\n                  <\/jats:p>","DOI":"10.1161\/circulationaha.106.644682","type":"journal-article","created":{"date-parts":[[2006,11,6]],"date-time":"2006-11-06T20:54:20Z","timestamp":1162846460000},"page":"2232-2239","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":980,"title":["Hypertrophic Cardiomyopathy Is Predominantly a Disease of Left Ventricular Outflow Tract Obstruction"],"prefix":"10.1161","volume":"114","author":[{"given":"Martin S.","family":"Maron","sequence":"first","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Division of Cardiology, Tufts-New England Medical Center, Boston, Mass (M.S.M., J.E.U., M.S.L., J.T.K., N.G.P.); Regional Referral Center for Myocardial Diseases, Azienda Ospedaliera Careggi, Florence, Italy (I.O., S.N., F.C.); and Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minn (A.G.Z., B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Olivotto","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Division of Cardiology, Tufts-New England Medical Center, Boston, Mass (M.S.M., J.E.U., M.S.L., J.T.K., N.G.P.); Regional Referral Center for Myocardial Diseases, Azienda Ospedaliera Careggi, Florence, Italy (I.O., S.N., F.C.); and Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minn (A.G.Z., B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey G.","family":"Zenovich","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Division of Cardiology, Tufts-New England Medical Center, Boston, Mass (M.S.M., J.E.U., M.S.L., J.T.K., N.G.P.); Regional Referral Center for Myocardial Diseases, Azienda Ospedaliera Careggi, Florence, Italy (I.O., S.N., F.C.); and Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minn (A.G.Z., B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Link","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Division of Cardiology, Tufts-New England Medical Center, Boston, Mass (M.S.M., J.E.U., M.S.L., J.T.K., N.G.P.); Regional Referral Center for Myocardial Diseases, Azienda Ospedaliera Careggi, Florence, Italy (I.O., S.N., F.C.); and Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minn (A.G.Z., B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natesa G.","family":"Pandian","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Division of Cardiology, Tufts-New England Medical Center, Boston, Mass (M.S.M., J.E.U., M.S.L., J.T.K., N.G.P.); Regional Referral Center for Myocardial Diseases, Azienda Ospedaliera Careggi, Florence, Italy (I.O., S.N., F.C.); and Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minn (A.G.Z., B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery T.","family":"Kuvin","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Division of Cardiology, Tufts-New England Medical Center, Boston, Mass (M.S.M., J.E.U., M.S.L., J.T.K., N.G.P.); Regional Referral Center for Myocardial Diseases, Azienda Ospedaliera Careggi, Florence, Italy (I.O., S.N., F.C.); and Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minn (A.G.Z., B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Nistri","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Division of Cardiology, Tufts-New England Medical Center, Boston, Mass (M.S.M., J.E.U., M.S.L., J.T.K., N.G.P.); Regional Referral Center for Myocardial Diseases, Azienda Ospedaliera Careggi, Florence, Italy (I.O., S.N., F.C.); and Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minn (A.G.Z., B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Cecchi","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Division of Cardiology, Tufts-New England Medical Center, Boston, Mass (M.S.M., J.E.U., M.S.L., J.T.K., N.G.P.); Regional Referral Center for Myocardial Diseases, Azienda Ospedaliera Careggi, Florence, Italy (I.O., S.N., F.C.); and Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minn (A.G.Z., B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Udelson","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Division of Cardiology, Tufts-New England Medical Center, Boston, Mass (M.S.M., J.E.U., M.S.L., J.T.K., N.G.P.); Regional Referral Center for Myocardial Diseases, Azienda Ospedaliera Careggi, Florence, Italy (I.O., S.N., F.C.); and Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minn (A.G.Z., B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry J.","family":"Maron","sequence":"additional","affiliation":[{"name":"From the Hypertrophic Cardiomyopathy Center, Division of Cardiology, Tufts-New England Medical Center, Boston, Mass (M.S.M., J.E.U., M.S.L., J.T.K., N.G.P.); Regional Referral Center for Myocardial Diseases, Azienda Ospedaliera Careggi, Florence, Italy (I.O., S.N., F.C.); and Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minn (A.G.Z., B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"221","volume":"106","year":"1957","unstructured":"Brock R. 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