{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:21:12Z","timestamp":1792020072979,"version":"4.4.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2007,7,10]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>Background\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Left ventricular wall motion (WM) abnormalities have recognized prognostic significance in patients with coronary or other heart diseases; however, whether abnormal WM predicts adverse events in adults without overt cardiovascular disease has not been assessed. Our objective was to determine whether echocardiographic WM abnormalities predict subsequent cardiovascular events in a population-based sample.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods and Results\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Participants (n=2864, mean age 60\u00b18 years, 64% women) without clinically evident cardiovascular disease in the second Strong Heart Study examination who had complete echocardiographic WM assessment were studied. Echocardiographic assessment revealed that 5% of participants (n=140) had focal hypokinesia, and 1.5% (n=42) had WM abnormalities. Relationships between WM abnormalities and fatal and nonfatal cardiovascular events (including myocardial infarction, stroke, coronary artery disease, and heart failure; n=554) and cardiovascular death (n=182) during 8\u00b12 years follow-up were examined. In Cox regression, after adjustment for age, gender, waist\/hip ratio, systolic blood pressure, and diabetes mellitus, segmental WM abnormalities were associated with a 2.5-fold higher risk of cardiovascular events and a 2.6-fold higher risk of cardiovascular death (both\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.0001). In similar multivariable models, global WM abnormalities were associated with a 2.4-fold higher risk of cardiovascular events (\n                    <jats:italic>P<\/jats:italic>\n                    =0.001) and a 3.4-fold higher risk of cardiovascular death (\n                    <jats:italic>P<\/jats:italic>\n                    =0.003).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusions\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Echocardiographic left ventricular WM abnormalities in adults without overt cardiovascular disease are associated with 2.4- to 3.4-fold higher risks of cardiovascular morbidity and mortality, independent of established risk factors.\n                  <\/jats:p>","DOI":"10.1161\/circulationaha.106.652149","type":"journal-article","created":{"date-parts":[[2007,6,18]],"date-time":"2007-06-18T21:10:41Z","timestamp":1182201041000},"page":"143-150","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":85,"title":["Prevalence and Prognostic Significance of Wall-Motion Abnormalities in Adults Without Clinically Recognized Cardiovascular Disease"],"prefix":"10.1161","volume":"116","author":[{"given":"Silvana","family":"Cicala","sequence":"first","affiliation":[{"name":"From the Greenberg Division of Cardiology (S.C., G.d.S., M.J.R., R.B.D.), Weill Cornell Medical College, New York, NY; Department of Clinical and Experimental Medicine (S.C., G.d.S.), Federico II University of Naples, Naples, Italy; Missouri Breaks Industries Research, Inc (L.G.B., T.K.W.), Timber Lake, SD; The University of Oklahoma School of Public Health Services (E.T.L., W.W.), Oklahoma City, Okla; University of Arizona Health Sciences Center (J.M.G.), Tucson, Ariz; and MedStar Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"de Simone","sequence":"additional","affiliation":[{"name":"From the Greenberg Division of Cardiology (S.C., G.d.S., M.J.R., R.B.D.), Weill Cornell Medical College, New York, NY; Department of Clinical and Experimental Medicine (S.C., G.d.S.), Federico II University of Naples, Naples, Italy; Missouri Breaks Industries Research, Inc (L.G.B., T.K.W.), Timber Lake, SD; The University of Oklahoma School of Public Health Services (E.T.L., W.W.), Oklahoma City, Okla; University of Arizona Health Sciences Center (J.M.G.), Tucson, Ariz; and MedStar Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary J.","family":"Roman","sequence":"additional","affiliation":[{"name":"From the Greenberg Division of Cardiology (S.C., G.d.S., M.J.R., R.B.D.), Weill Cornell Medical College, New York, NY; Department of Clinical and Experimental Medicine (S.C., G.d.S.), Federico II University of Naples, Naples, Italy; Missouri Breaks Industries Research, Inc (L.G.B., T.K.W.), Timber Lake, SD; The University of Oklahoma School of Public Health Services (E.T.L., W.W.), Oklahoma City, Okla; University of Arizona Health Sciences Center (J.M.G.), Tucson, Ariz; and MedStar Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyle G.","family":"Best","sequence":"additional","affiliation":[{"name":"From the Greenberg Division of Cardiology (S.C., G.d.S., M.J.R., R.B.D.), Weill Cornell Medical College, New York, NY; Department of Clinical and Experimental Medicine (S.C., G.d.S.), Federico II University of Naples, Naples, Italy; Missouri Breaks Industries Research, Inc (L.G.B., T.K.W.), Timber Lake, SD; The University of Oklahoma School of Public Health Services (E.T.L., W.W.), Oklahoma City, Okla; University of Arizona Health Sciences Center (J.M.G.), Tucson, Ariz; and MedStar Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa T.","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Greenberg Division of Cardiology (S.C., G.d.S., M.J.R., R.B.D.), Weill Cornell Medical College, New York, NY; Department of Clinical and Experimental Medicine (S.C., G.d.S.), Federico II University of Naples, Naples, Italy; Missouri Breaks Industries Research, Inc (L.G.B., T.K.W.), Timber Lake, SD; The University of Oklahoma School of Public Health Services (E.T.L., W.W.), Oklahoma City, Okla; University of Arizona Health Sciences Center (J.M.G.), Tucson, Ariz; and MedStar Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Greenberg Division of Cardiology (S.C., G.d.S., M.J.R., R.B.D.), Weill Cornell Medical College, New York, NY; Department of Clinical and Experimental Medicine (S.C., G.d.S.), Federico II University of Naples, Naples, Italy; Missouri Breaks Industries Research, Inc (L.G.B., T.K.W.), Timber Lake, SD; The University of Oklahoma School of Public Health Services (E.T.L., W.W.), Oklahoma City, Okla; University of Arizona Health Sciences Center (J.M.G.), Tucson, Ariz; and MedStar Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas K.","family":"Welty","sequence":"additional","affiliation":[{"name":"From the Greenberg Division of Cardiology (S.C., G.d.S., M.J.R., R.B.D.), Weill Cornell Medical College, New York, NY; Department of Clinical and Experimental Medicine (S.C., G.d.S.), Federico II University of Naples, Naples, Italy; Missouri Breaks Industries Research, Inc (L.G.B., T.K.W.), Timber Lake, SD; The University of Oklahoma School of Public Health Services (E.T.L., W.W.), Oklahoma City, Okla; University of Arizona Health Sciences Center (J.M.G.), Tucson, Ariz; and MedStar Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Galloway","sequence":"additional","affiliation":[{"name":"From the Greenberg Division of Cardiology (S.C., G.d.S., M.J.R., R.B.D.), Weill Cornell Medical College, New York, NY; Department of Clinical and Experimental Medicine (S.C., G.d.S.), Federico II University of Naples, Naples, Italy; Missouri Breaks Industries Research, Inc (L.G.B., T.K.W.), Timber Lake, SD; The University of Oklahoma School of Public Health Services (E.T.L., W.W.), Oklahoma City, Okla; University of Arizona Health Sciences Center (J.M.G.), Tucson, Ariz; and MedStar Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara V.","family":"Howard","sequence":"additional","affiliation":[{"name":"From the Greenberg Division of Cardiology (S.C., G.d.S., M.J.R., R.B.D.), Weill Cornell Medical College, New York, NY; Department of Clinical and Experimental Medicine (S.C., G.d.S.), Federico II University of Naples, Naples, Italy; Missouri Breaks Industries Research, Inc (L.G.B., T.K.W.), Timber Lake, SD; The University of Oklahoma School of Public Health Services (E.T.L., W.W.), Oklahoma City, Okla; University of Arizona Health Sciences Center (J.M.G.), Tucson, Ariz; and MedStar Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Devereux","sequence":"additional","affiliation":[{"name":"From the Greenberg Division of Cardiology (S.C., G.d.S., M.J.R., R.B.D.), Weill Cornell Medical College, New York, NY; Department of Clinical and Experimental Medicine (S.C., G.d.S.), Federico II University of Naples, Naples, Italy; Missouri Breaks Industries Research, Inc (L.G.B., T.K.W.), Timber Lake, SD; The University of Oklahoma School of Public Health Services (E.T.L., W.W.), Oklahoma City, Okla; University of Arizona Health Sciences Center (J.M.G.), Tucson, Ariz; 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