{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:32:16Z","timestamp":1791048736407,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2007,4,17]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Brugada syndrome is an arrhythmogenic disease characterized by an ECG pattern of ST-segment elevation in the right precordial leads and augmented risk of sudden cardiac death. Little is known about the clinical presentation and prognosis of this disease in children.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Thirty children affected by Brugada syndrome who were &lt;16 years of age (mean, 8\u00b14 years) were included. All patients displayed a type I ECG pattern before or after drug provocation challenge. Diagnosis of Brugada syndrome was made under the following circumstances: aborted sudden death (n=1), syncope of unexplained origin (n=10), symptomatic supraventricular tachycardia (n=1), suspicious ECG (n=1), and family screening for Brugada syndrome (n=17). Syncope was precipitated by fever in 5 cases. Ten of 11 symptomatic patients displayed a spontaneous type I ECG. An implantable cardioverter-defibrillator was implanted in 5 children; 4 children were treated with hydroquinidine; and 1 child received a pacemaker because of symptomatic sick sinus syndrome. During a mean follow-up of 37\u00b123 months, 1 child experienced sudden cardiac death, and 2 children received an appropriate implantable cardioverter-defibrillator shock; all of them were symptomatic and had manifested a type I ECG spontaneously. One child had a cardioverter-defibrillator infection that required explantation of the defibrillator.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            In the largest population of children affected by Brugada syndrome described to date, fever represented the most important precipitating factor for arrhythmic events, and as in the adult population, the risk of arrhythmic events was higher in previously symptomatic patients and in those displaying a spontaneous type I ECG.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.106.664219","type":"journal-article","created":{"date-parts":[[2007,4,3]],"date-time":"2007-04-03T00:58:39Z","timestamp":1175561919000},"page":"2042-2048","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":256,"title":["Clinical Aspects and Prognosis of Brugada Syndrome in Children"],"prefix":"10.1161","volume":"115","author":[{"given":"Vincent","family":"Probst","sequence":"first","affiliation":[{"name":"From L\u2019Institut du Thorax, CHU de Nantes (V.P., J.A., H.L.M.), INSERM U533 (V.P., J.S., H.L.M.), and CIC de Nantes (V.P., J.A., H.L.M.), Nantes, France; Lariboisie\u0300re Hospital and Centre Cardiologique Infantile (I.D.), Cha\u0302teau des Co\u0302tes, Les Loges en Josas, France; Department of Cardiology (P.G.M., A.A.M.W.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Service de Cardiologie (F.S., M.H.), Ho\u0302pital Cardiologique du Haut Leveque, Bordeaux, France; Service de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Denjoy","sequence":"additional","affiliation":[{"name":"From L\u2019Institut du Thorax, CHU de Nantes (V.P., J.A., H.L.M.), INSERM U533 (V.P., J.S., H.L.M.), and CIC de Nantes (V.P., J.A., H.L.M.), Nantes, France; Lariboisie\u0300re Hospital and Centre Cardiologique Infantile (I.D.), Cha\u0302teau des Co\u0302tes, Les Loges en Josas, France; Department of Cardiology (P.G.M., A.A.M.W.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Service de Cardiologie (F.S., M.H.), Ho\u0302pital Cardiologique du Haut Leveque, Bordeaux, France; Service de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola G.","family":"Meregalli","sequence":"additional","affiliation":[{"name":"From L\u2019Institut du Thorax, CHU de Nantes (V.P., J.A., H.L.M.), INSERM U533 (V.P., J.S., H.L.M.), and CIC de Nantes (V.P., J.A., H.L.M.), Nantes, France; Lariboisie\u0300re Hospital and Centre Cardiologique Infantile (I.D.), Cha\u0302teau des Co\u0302tes, Les Loges en Josas, France; Department of Cardiology (P.G.M., A.A.M.W.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Service de Cardiologie (F.S., M.H.), Ho\u0302pital Cardiologique du Haut Leveque, Bordeaux, France; Service de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Amirault","sequence":"additional","affiliation":[{"name":"From L\u2019Institut du Thorax, CHU de Nantes (V.P., J.A., H.L.M.), INSERM U533 (V.P., J.S., H.L.M.), and CIC de Nantes (V.P., J.A., H.L.M.), Nantes, France; Lariboisie\u0300re Hospital and Centre Cardiologique Infantile (I.D.), Cha\u0302teau des Co\u0302tes, Les Loges en Josas, France; Department of Cardiology (P.G.M., A.A.M.W.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Service de Cardiologie (F.S., M.H.), Ho\u0302pital Cardiologique du Haut Leveque, Bordeaux, France; Service de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fre\u0301deric","family":"Sacher","sequence":"additional","affiliation":[{"name":"From L\u2019Institut du Thorax, CHU de Nantes (V.P., J.A., H.L.M.), INSERM U533 (V.P., J.S., H.L.M.), and CIC de Nantes (V.P., J.A., H.L.M.), Nantes, France; Lariboisie\u0300re Hospital and Centre Cardiologique Infantile (I.D.), Cha\u0302teau des Co\u0302tes, Les Loges en Josas, France; Department of Cardiology (P.G.M., A.A.M.W.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Service de Cardiologie (F.S., M.H.), Ho\u0302pital Cardiologique du Haut Leveque, Bordeaux, France; Service de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Mansourati","sequence":"additional","affiliation":[{"name":"From L\u2019Institut du Thorax, CHU de Nantes (V.P., J.A., H.L.M.), INSERM U533 (V.P., J.S., H.L.M.), and CIC de Nantes (V.P., J.A., H.L.M.), Nantes, France; Lariboisie\u0300re Hospital and Centre Cardiologique Infantile (I.D.), Cha\u0302teau des Co\u0302tes, Les Loges en Josas, France; Department of Cardiology (P.G.M., A.A.M.W.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Service de Cardiologie (F.S., M.H.), Ho\u0302pital Cardiologique du Haut Leveque, Bordeaux, France; Service de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Babuty","sequence":"additional","affiliation":[{"name":"From L\u2019Institut du Thorax, CHU de Nantes (V.P., J.A., H.L.M.), INSERM U533 (V.P., J.S., H.L.M.), and CIC de Nantes (V.P., J.A., H.L.M.), Nantes, France; Lariboisie\u0300re Hospital and Centre Cardiologique Infantile (I.D.), Cha\u0302teau des Co\u0302tes, Les Loges en Josas, France; Department of Cardiology (P.G.M., A.A.M.W.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Service de Cardiologie (F.S., M.H.), Ho\u0302pital Cardiologique du Haut Leveque, Bordeaux, France; 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Department of Cardiology (P.G.M., A.A.M.W.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Service de Cardiologie (F.S., M.H.), Ho\u0302pital Cardiologique du Haut Leveque, Bordeaux, France; Service de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Schott","sequence":"additional","affiliation":[{"name":"From L\u2019Institut du Thorax, CHU de Nantes (V.P., J.A., H.L.M.), INSERM U533 (V.P., J.S., H.L.M.), and CIC de Nantes (V.P., J.A., H.L.M.), Nantes, France; Lariboisie\u0300re Hospital and Centre Cardiologique Infantile (I.D.), Cha\u0302teau des Co\u0302tes, Les Loges en Josas, France; Department of Cardiology (P.G.M., A.A.M.W.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Service de Cardiologie (F.S., M.H.), Ho\u0302pital Cardiologique du Haut Leveque, Bordeaux, France; Service de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Lupoglazoff","sequence":"additional","affiliation":[{"name":"From L\u2019Institut du Thorax, CHU de Nantes (V.P., J.A., H.L.M.), INSERM U533 (V.P., J.S., H.L.M.), and CIC de Nantes (V.P., J.A., H.L.M.), Nantes, France; Lariboisie\u0300re Hospital and Centre Cardiologique Infantile (I.D.), Cha\u0302teau des Co\u0302tes, Les Loges en Josas, France; Department of Cardiology (P.G.M., A.A.M.W.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Service de Cardiologie (F.S., M.H.), Ho\u0302pital Cardiologique du Haut Leveque, Bordeaux, France; Service de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Mabo","sequence":"additional","affiliation":[{"name":"From L\u2019Institut du Thorax, CHU de Nantes (V.P., J.A., H.L.M.), INSERM U533 (V.P., J.S., H.L.M.), and CIC de Nantes (V.P., J.A., H.L.M.), Nantes, France; Lariboisie\u0300re Hospital and Centre Cardiologique Infantile (I.D.), Cha\u0302teau des Co\u0302tes, Les Loges en Josas, France; Department of Cardiology (P.G.M., A.A.M.W.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Service de Cardiologie (F.S., M.H.), Ho\u0302pital Cardiologique du Haut Leveque, Bordeaux, France; 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Department of Cardiology (P.G.M., A.A.M.W.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Service de Cardiologie (F.S., M.H.), Ho\u0302pital Cardiologique du Haut Leveque, Bordeaux, France; Service de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chevalier","sequence":"additional","affiliation":[{"name":"From L\u2019Institut du Thorax, CHU de Nantes (V.P., J.A., H.L.M.), INSERM U533 (V.P., J.S., H.L.M.), and CIC de Nantes (V.P., J.A., H.L.M.), Nantes, France; Lariboisie\u0300re Hospital and Centre Cardiologique Infantile (I.D.), Cha\u0302teau des Co\u0302tes, Les Loges en Josas, France; Department of Cardiology (P.G.M., A.A.M.W.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Service de Cardiologie (F.S., M.H.), Ho\u0302pital Cardiologique du Haut Leveque, Bordeaux, France; Service de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally-Ann B.","family":"Clur","sequence":"additional","affiliation":[{"name":"From L\u2019Institut du Thorax, CHU de Nantes (V.P., J.A., H.L.M.), INSERM U533 (V.P., J.S., H.L.M.), and CIC de Nantes (V.P., J.A., H.L.M.), Nantes, France; 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