{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:03:57Z","timestamp":1791475437673,"version":"4.3.4"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11_supplement","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2007,9,11]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>Background\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Myocardial and renal injury commonly contribute to perioperative morbidity and mortality after abdominal aortic aneurysm repair. Remote ischemic preconditioning (RIPC) is a phenomenon whereby brief periods of ischemia followed by reperfusion in one organ provide systemic protection from prolonged ischemia. To investigate whether remote preconditioning reduces the incidence of myocardial and renal injury in patients undergoing elective open abdominal aortic aneurysm repair, we performed a randomized trial.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Method and Results\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Eighty-two patients were randomized to abdominal aortic aneurysm repair with RIPC or conventional abdominal aortic aneurysm repair (control). Two cycles of intermittent crossclamping of the common iliac artery with 10 minutes ischemia followed by 10 minutes reperfusion served as the RIPC stimulus. Myocardial injury was assessed by cardiac troponin I (&gt;0.40 ng\/mL), myocardial infarction by the American College of Cardiology\/American Heart Association definition and renal injury by serum creatinine (&gt;177 \u03bcmol\/L) according to American Heart Association guidelines for risk stratification in major vascular surgery. The groups were well matched for baseline characteristics. RIPC reduced the incidence of myocardial injury by 27% (39% versus 12% [95% CI: 8.8% to 45%];\n                    <jats:italic>P<\/jats:italic>\n                    =0.005), myocardial infarction by 22% (27% versus 5% [95% CI: 7.3% to 38%];\n                    <jats:italic>P<\/jats:italic>\n                    =0.006), and renal impairment by 23% (30% versus 7%; [95% CI: 6.4 to 39];\n                    <jats:italic>P<\/jats:italic>\n                    =0.009). Multivariable analysis revealed the protective effect of RIPC on myocardial injury (OR: 0.22, 95% CI: 0.07 to 0.67;\n                    <jats:italic>P<\/jats:italic>\n                    =0.008), myocardial infarction (OR: 0.18, 95% CI: 0.04 to 0.75;\n                    <jats:italic>P<\/jats:italic>\n                    =0.006) and renal impairment were independent of other covariables.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusions\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    In patients undergoing elective open abdominal aortic aneurysm repair, RIPC reduces the incidence of postoperative myocardial injury, myocardial infarction, and renal impairment.\n                  <\/jats:p>","DOI":"10.1161\/circulationaha.106.679167","type":"journal-article","created":{"date-parts":[[2007,9,10]],"date-time":"2007-09-10T16:58:24Z","timestamp":1189443504000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":223,"title":["Remote Ischemic Preconditioning Reduces Myocardial and Renal Injury After Elective Abdominal Aortic Aneurysm Repair"],"prefix":"10.1161","volume":"116","author":[{"given":"Ziad A.","family":"Ali","sequence":"first","affiliation":[{"name":"From the Cardiovascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris J.","family":"Callaghan","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Lim","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayyaz A.","family":"Ali","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.A.","family":"Reza Nouraei","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim M.","family":"Akthar","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Boyle","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Varty","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh K.","family":"Kharbanda","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Dutka","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Gaunt","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198301001-00008"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.07.136"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041905"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(96)00130-0"},{"key":"e_1_3_3_5_2","first-page":"1278","volume":"93","year":"1996","unstructured":"Eagle KA, Brundage BH, Chaitman BR, Ewy GA, Fleisher LA, Hertzer NR, Leppo JA, Ryan T, Schlant RC, Spencer WH 3rd, Spittell JA Jr, Twiss RD, Ritchie JL, Cheitlin MD, Gardner TJ, Garson A Jr, Lewis RP, Gibbons RJ, O\u2019Rourke RA, Ryan TJ. 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A personal experience with factors influencing survival after elective open repair of infrarenal aortic aneurysms. 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