{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:02:29Z","timestamp":1774123349306,"version":"3.50.1"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2007,6,5]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Although \u03b2-blockers are known to prolong survival for patients with reduced left ventricular ejection fraction, they are often underused. We hypothesized that a reminder attached to the echocardiography report would increase the use of \u03b2-blockers for patients with reduced left ventricular ejection fraction.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            We randomized 1546 consecutive patients with a left ventricular ejection fraction &lt;45% found on echocardiography at 1 of 3 laboratories to a reminder for use of \u03b2-blockers or no reminder. Patients were excluded from analysis if they died within 30 days of randomization (n=89), did not receive medications through the Veterans Affairs system after 30 days (n=180), or underwent echocardiography at &gt;1 laboratory (n=6). The primary outcome was a prescription for an oral \u03b2-blocker between 1 and 9 months after randomization. The mean age of the 1271 included patients was 69 years; 60% had a history of heart failure, and 51% were receiving treatment with \u03b2-blockers at the time of echocardiography. More patients randomized to the reminder had a subsequent \u03b2-blocker prescription (74%, 458 of 621) compared with those randomized to no reminder (66%, 428 of 650;\n            <jats:italic>P<\/jats:italic>\n            =0.002). The effect of the reminder was not significantly different for subgroups based on patient location (inpatient versus outpatient) or prior use of \u03b2-blockers.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            A reminder attached to the echocardiography report increased the use of \u03b2-blockers in patients with depressed left ventricular systolic function.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.106.684753","type":"journal-article","created":{"date-parts":[[2007,5,22]],"date-time":"2007-05-22T17:22:58Z","timestamp":1179854578000},"page":"2829-2834","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["Clinical Reminders Attached to Echocardiography Reports of Patients With Reduced Left Ventricular Ejection Fraction Increase Use of \u03b2-Blockers"],"prefix":"10.1161","volume":"115","author":[{"given":"Paul A.","family":"Heidenreich","sequence":"first","affiliation":[{"name":"From the VA Palo Alto Health Care System (P.A.H., P.G., A.S., M.K.G.) and Department of Medicine, Stanford University (P.A.H., M.K.G.), Stanford, Calif; and San Francisco VA Medical Center and Department of Medicine, University of California at San Francisco (B.M.), San Francisco, Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parisa","family":"Gholami","sequence":"additional","affiliation":[{"name":"From the VA Palo Alto Health Care System (P.A.H., P.G., A.S., M.K.G.) and Department of Medicine, Stanford University (P.A.H., M.K.G.), Stanford, Calif; and San Francisco VA Medical Center and Department of Medicine, University of California at San Francisco (B.M.), San Francisco, Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anju","family":"Sahay","sequence":"additional","affiliation":[{"name":"From the VA Palo Alto Health Care System (P.A.H., P.G., A.S., M.K.G.) and Department of Medicine, Stanford University (P.A.H., M.K.G.), Stanford, Calif; and San Francisco VA Medical Center and Department of Medicine, University of California at San Francisco (B.M.), San Francisco, Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Massie","sequence":"additional","affiliation":[{"name":"From the VA Palo Alto Health Care System (P.A.H., P.G., A.S., M.K.G.) and Department of Medicine, Stanford University (P.A.H., M.K.G.), Stanford, Calif; and San Francisco VA Medical Center and Department of Medicine, University of California at San Francisco (B.M.), San Francisco, Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary K.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"From the VA Palo Alto Health Care System (P.A.H., P.G., A.S., M.K.G.) and Department of Medicine, Stanford University (P.A.H., M.K.G.), Stanford, Calif; and San Francisco VA Medical Center and Department of Medicine, University of California at San Francisco (B.M.), San Francisco, Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.553370"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi204"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2006.01.001"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.170072"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.12.025"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2004.06.436"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.21.2486"},{"key":"e_1_3_3_8_2","first-page":"878","volume":"10","year":"2004","unstructured":"Fung CH, Woods JN, Asch SM, Glassman P, Doebbeling BN. 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Rev Cardiovasc Med. 2002; 3 (suppl 3): S42\u2013S47.","journal-title":"Rev Cardiovasc Med"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.10114"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.116479"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.106.684753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T05:04:27Z","timestamp":1715576667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.106.684753"}},"subtitle":["A Randomized Trial"],"short-title":[],"issued":{"date-parts":[[2007,6,5]]},"references-count":20,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2007,6,5]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.106.684753"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.106.684753","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,5]]},"assertion":[{"value":"2007-05-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}