{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:24:00Z","timestamp":1777116240791,"version":"3.51.4"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2007,7,10]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            The presence of a lumen narrowing at the ostium and the body of an unprotected left main coronary artery but does not require bifurcation treatment is a class I indication of surgical revascularization.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            A total of 147 consecutive patients who had a stenosis in the ostium and\/or the midshaft of an unprotected left main coronary artery (treatment of the bifurcation not required) and were electively treated with percutaneous coronary intervention and sirolimus-eluting stents (n=107) or paclitaxel-eluting stents (n=40) in 5 centres were included in this registry. In 72 patients (almost 50%), intravascular ultrasound guidance was performed. Procedural success was achieved in 99% of the patients; in 1 patient with stenosis in the left main coronary artery ostium, a &gt;30% residual stenosis persisted at the end of the procedure, and the patient was referred for coronary artery bypass graft surgery. During hospitalization, no patients experienced a Q-wave myocardial infarction or died. One patient died 19 days after the procedure because of pulmonary infection. At long-term clinical follow-up (886\u00b1308 days), 5 patients had died; 7 patients had target vessel revascularization (5 repeat percutaneous coronary interventions and 2 coronary artery bypass graft surgeries), and of these only 1 patient had a target lesion revascularization. Angiographic follow-up was performed in 106 patients (72%) with a late loss of \u22120.01 mm. Restenosis in the left main trunk occurred only in 1 patient (0.9%).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Percutaneous coronary intervention with sirolimus-eluting stents or paclitaxel-eluting stents implantation in nonbifurcation left main coronary artery lesions appears safe with a long-term major adverse clinical event rate of 7.4% and a restenosis rate of 0.9%.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.107.692178","type":"journal-article","created":{"date-parts":[[2007,6,19]],"date-time":"2007-06-19T01:10:41Z","timestamp":1182215441000},"page":"158-162","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":166,"title":["Favorable Long-Term Outcome After Drug-Eluting Stent Implantation in Nonbifurcation Lesions That Involve Unprotected Left Main Coronary Artery"],"prefix":"10.1161","volume":"116","author":[{"given":"Alaide","family":"Chieffo","sequence":"first","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung J.","family":"Park","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Valgimigli","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young H.","family":"Kim","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joost","family":"Daemen","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imad","family":"Sheiban","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Truffa","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Montorfano","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"Airoldi","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Sangiorgi","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Carlino","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iassen","family":"Michev","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol W.","family":"Lee","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myeong K.","family":"Hong","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong W.","family":"Park","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Moretti","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erminio","family":"Bonizzoni","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Rogacka","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick W.","family":"Serruys","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Colombo","sequence":"additional","affiliation":[{"name":"From the San Raffaele Scientific Institute and Emo Centro Cuore Columbus (A.C., M.M., F.A., G.S., M.C., I.M., R.R., A.C.), Milan, Italy; the Asan Medical Center (S.J.P., Y.H.K., C.W.L., M.K.H., S.W.P.), University of Ulsan College of Medicine, Seoul, Republic of Korea; the Erasmus Medical Center (M.V., J.D., P.W.S.), Thoraxcenter, Rotterdam, the Netherlands; San Giovanni Battista Hospital (I.S., A.T., C.M.), Turin, Italy; and the Institute of Medical Statistics and Biometry (E.B.), University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000138790.14877.7d"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi138"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.557561"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0272"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000155256.88940.f8"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.03.011"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.10.039"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.040"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000158486.20865.8b"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.12.016"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.11.066"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000131890.83839.5b"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000086926.62288.a6"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035071"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032441"},{"key":"e_1_3_2_16_2","unstructured":"Colombo A Chieffo A. 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