{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:06:40Z","timestamp":1790867200155,"version":"4.1.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2007,11,20]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>Background\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Concern regarding risk of late thrombosis after \u201coff-label\u201d treatment with drug-eluting stents has prompted increased use of bare-metal stents (BMS) in current practice. The sequelae of late BMS failures, however, have been poorly characterized.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods and Results\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    We performed a retrospective study of 4503 consecutive patients treated with at least 1 BMS and dual antiplatelet therapy between 1994 and 2000. The cumulative incidence of stent thrombosis was 0.5% at 30 days (95% CI, 0.3% to 0.7%), 0.8% at 1 year (95% CI, 0.6% to 1.1%), and 2.0% at 10 years (95% CI, 1.5% to 2.5%). Risk of late (30 days to 1 year) and very late (&gt;1 year) BMS thrombosis was increased among patients considered off label for drug-eluting stent use (\n                    <jats:italic>P<\/jats:italic>\n                    =0.024). When saphenous vein graft interventions were excluded, however, risk after off-label use was not significantly increased (\n                    <jats:italic>P<\/jats:italic>\n                    =0.23). Other correlates included vein graft intervention, prior myocardial infarction (MI), peripheral vascular disease, and ulcerated lesion (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001). Mortality was markedly increased after late and very late BMS thrombosis, particularly during the first 30 days (hazard ratios, 22 [95% CI, 3.1 to 159] and 40 [95% CI, 15 to 107], respectively). The 10-year incidence of clinical restenosis was 18.1% (95% CI, 16.5% to 19.7%), presenting with MI in 2.1% (95% CI, 1.6% to 2.6%). Restenosis presenting with MI was associated with increased mortality compared with no restenosis (hazard ratio, 2.37;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001) and with restenosis with a non-MI presentation (hazard ratio, 2.42;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusions\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    The incidence of BMS thrombosis and of MI caused by restenosis during extended follow-up is significant. Both complications are associated with mortality.\n                  <\/jats:p>","DOI":"10.1161\/circulationaha.107.707331","type":"journal-article","created":{"date-parts":[[2007,11,5]],"date-time":"2007-11-05T20:54:50Z","timestamp":1194296090000},"page":"2391-2398","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":167,"title":["Outcomes of Stent Thrombosis and Restenosis During Extended Follow-Up of Patients Treated With Bare-Metal Coronary Stents"],"prefix":"10.1161","volume":"116","author":[{"given":"Brendan","family":"Doyle","sequence":"first","affiliation":[{"name":"From the Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charanjit S.","family":"Rihal","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crochan J.","family":"O\u2019Sullivan","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Lennon","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Wiste","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Bell","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Bresnahan","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"David R.","family":"Holmes","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, 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