{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:51:42Z","timestamp":1789685502663,"version":"4.0.1"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2008,9,23]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Calcification of the thoracic aorta is associated with atherosclerotic risk factors, yet its pathogenesis and clinical implications are not yet elucidated. The goal of the present study was to assess whether thoracic aorta calcification is associated with an increased risk of cardiovascular events and death in patients with stable angina pectoris.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            A prospective cohort of 361 stable angina pectoris patients (307 men, 54 women; age range, 37 to 83 years) underwent chest spiral computed tomography and were evaluated for aortic calcification. We recorded the incidence of cardiovascular events and death during a 4.5- to 6-year follow-up. Aortic calcification was documented in 253 patients (70% of patients; 213 men, 40 women). Patients with aortic calcification were older (mean age, 65\u00b17 versus 55\u00b19 years;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001), and fewer were classified as smokers (13% versus 26%;\n            <jats:italic>P<\/jats:italic>\n            =0.014) compared with patients without aortic calcification. Significant correlation was found between patients with and those without aortic calcification for the presence of aortic valve calcification (28% versus 11%;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001), mitral annulus calcification (29% versus 4%;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001), and coronary calcification as expressed by coronary calcium score. (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). During 4.5 to 6 years of follow-up, 19 patients died, all of whom were in the aortic calcification group. Age-adjusted hazard ratios for total events and cardiovascular events by aortic calcification were 2.84 (95% CI, 1.52 to 5.30;\n            <jats:italic>P<\/jats:italic>\n            =0.001) and 2.70 (95% CI, 1.33 to 5.47;\n            <jats:italic>P<\/jats:italic>\n            =0.006), respectively. In multivariable analysis, hazard ratios for total events and cardiovascular events were 2.79 (95% CI, 1.46 to 5.20;\n            <jats:italic>P<\/jats:italic>\n            =0.002) and 4.65 (95% CI, 1.19 to 18.26;\n            <jats:italic>P<\/jats:italic>\n            =0.028), respectively.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Calcification of the thoracic aorta is age related and associated with coronary calcification and valvular calcification. Thoracic aortic calcification is associated with an increased risk of death and cardiovascular disease.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.107.712141","type":"journal-article","created":{"date-parts":[[2008,9,9]],"date-time":"2008-09-09T00:45:42Z","timestamp":1220921142000},"page":"1328-1334","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":131,"title":["Calcification of the Thoracic Aorta as Detected by Spiral Computed Tomography Among Stable Angina Pectoris Patients"],"prefix":"10.1161","volume":"118","author":[{"given":"Alon","family":"Eisen","sequence":"first","affiliation":[{"name":"From the Cardiac Rehabilitation Institute (A.E., A.T., N.K.-M., J.S., E.Z.F., M.M., E.S., Y.A.) and Stroke Center, Department of Neurology (D.T.), Chaim Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, and Cardiology Department (M.I.), Maria Vittoria Hospital, Torino, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Tenenbaum","sequence":"additional","affiliation":[{"name":"From the Cardiac Rehabilitation Institute (A.E., A.T., N.K.-M., J.S., E.Z.F., M.M., E.S., Y.A.) and Stroke Center, Department of Neurology (D.T.), Chaim Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, and Cardiology Department (M.I.), Maria Vittoria Hospital, Torino, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nira","family":"Koren-Morag","sequence":"additional","affiliation":[{"name":"From the Cardiac Rehabilitation Institute (A.E., A.T., N.K.-M., J.S., E.Z.F., M.M., E.S., Y.A.) and Stroke Center, Department of Neurology (D.T.), Chaim Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, and Cardiology Department (M.I.), Maria Vittoria Hospital, Torino, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tanne","sequence":"additional","affiliation":[{"name":"From the Cardiac Rehabilitation Institute (A.E., A.T., N.K.-M., J.S., E.Z.F., M.M., E.S., Y.A.) and Stroke Center, Department of Neurology (D.T.), Chaim Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, and Cardiology Department (M.I.), Maria Vittoria Hospital, Torino, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Shemesh","sequence":"additional","affiliation":[{"name":"From the Cardiac Rehabilitation Institute (A.E., A.T., N.K.-M., J.S., E.Z.F., M.M., E.S., Y.A.) and Stroke Center, Department of Neurology (D.T.), Chaim Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, and Cardiology Department (M.I.), Maria Vittoria Hospital, Torino, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Imazio","sequence":"additional","affiliation":[{"name":"From the Cardiac Rehabilitation Institute (A.E., A.T., N.K.-M., J.S., E.Z.F., M.M., E.S., Y.A.) and Stroke Center, Department of Neurology (D.T.), Chaim Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, and Cardiology Department (M.I.), Maria Vittoria Hospital, Torino, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique Z.","family":"Fisman","sequence":"additional","affiliation":[{"name":"From the Cardiac Rehabilitation Institute (A.E., A.T., N.K.-M., J.S., E.Z.F., M.M., E.S., Y.A.) and Stroke Center, Department of Neurology (D.T.), Chaim Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, and Cardiology Department (M.I.), Maria Vittoria Hospital, Torino, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Motro","sequence":"additional","affiliation":[{"name":"From the Cardiac Rehabilitation Institute (A.E., A.T., N.K.-M., J.S., E.Z.F., M.M., E.S., Y.A.) and Stroke Center, Department of Neurology (D.T.), Chaim Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, and Cardiology Department (M.I.), Maria Vittoria Hospital, Torino, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehud","family":"Schwammenthal","sequence":"additional","affiliation":[{"name":"From the Cardiac Rehabilitation Institute (A.E., A.T., N.K.-M., J.S., E.Z.F., M.M., E.S., Y.A.) and Stroke Center, Department of Neurology (D.T.), Chaim Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, and Cardiology Department (M.I.), Maria Vittoria Hospital, Torino, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda","family":"Adler","sequence":"additional","affiliation":[{"name":"From the Cardiac Rehabilitation Institute (A.E., A.T., N.K.-M., J.S., E.Z.F., M.M., E.S., Y.A.) and Stroke Center, Department of Neurology (D.T.), Chaim Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, and Cardiology Department (M.I.), Maria Vittoria Hospital, Torino, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.208.1.9646807"},{"key":"e_1_3_2_2_2","first-page":"1","volume":"2","year":"2000","unstructured":"Tenenbaum A, Garniek A, Shemesh J, Stroh CI, Itzchak Y, Vered Z, Motro M, Fisman EZ. Spiral computerized tomography (dual helical mode) as a detector of aortic atheromas in patients with stroke and systemic emboli: additional benefit of the contrast-enhanced technique. Isr Med Assoc J. 2000; 2: 1\u20135.","journal-title":"Isr Med Assoc J"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000006795"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.12.1515"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(03)00105-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331970305400407"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.03.027"},{"key":"e_1_3_2_8_2","first-page":"277","volume":"9","year":"2007","unstructured":"Eisen A, Tenenbaum A, Tanne D, Koren-Morag N, Shemesh J, Goaln A, Fisman EZ, Motro M, Schwammenthal E, Adler Y. Coronary and aortic calcifications interrelationship in stable angina pectoris: A Coronary Disease Trial Investigating Outcome With Nifedipine GITS (ACTION)\u2013 Israeli spiral computed tomography substudy. Isr Med Assoc J. 2007; 9: 277\u2013280.","journal-title":"Isr Med Assoc J"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.21.2810"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.103.11.1529"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.08.010"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16980-8"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.197.3.7480756"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90282-T"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2003.169"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00906-6"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00002027"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.029"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01454.x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.12.017"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2007.01768.x"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.11.065"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.107.712141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T06:23:36Z","timestamp":1715581416000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.107.712141"}},"subtitle":["Association With Cardiovascular Events and Death"],"short-title":[],"issued":{"date-parts":[[2008,9,23]]},"references-count":22,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2008,9,23]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.107.712141"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.107.712141","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,23]]},"assertion":[{"value":"2008-09-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}