{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:34:05Z","timestamp":1787906045151,"version":"build-2784847793"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2008,5,20]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Obesity is a risk factor for atrial fibrillation and other cardiovascular conditions. Our objective was to determine whether catheter-based ablation effectively treated atrial fibrillation in obese patients.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Five hundred twenty-three consecutive patients with symptomatic, medication-refractory atrial fibrillation underwent catheter ablation. Patients were grouped by body mass index (lean, &lt;25 kg\/m\n            <jats:sup>2<\/jats:sup>\n            ; overweight, 25 to 29.9 kg\/m\n            <jats:sup>2<\/jats:sup>\n            ; obese, \u226530 kg\/m\n            <jats:sup>2<\/jats:sup>\n            ). Outcome and quality of life were measured with a general health survey (Medical Outcomes Study 36-item Short-Form General Health Survey [SF-36]); patients were assessed before ablation and at 3 and 12 months after the procedure. Two hundred twenty-eight study patients (44%) were overweight, and 201 (38%) were obese. Twelve months after curative ablation, 72% of patients were free of atrial fibrillation without the use of antiarrhythmic agents; 84% were arrhythmia free when those receiving medication were included. Atrial fibrillation was eliminated in 75%, 72%, and 70% of the lean, overweight, and obese patients, respectively, at 12 months (\n            <jats:italic>P<\/jats:italic>\n            =0.41, trend test). SF-36 scores were lower for patients with higher body mass index (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05) at baseline. SF-36 scores improved in every functional domain for all body mass index groups after ablation. The mean SF-36 total physical score increased from 59\u00b120 at baseline to 77\u00b119 in 12 months (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). The total mental health score improved from 66\u00b118 to 79\u00b116 in 12 months (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Catheter ablation of atrial fibrillation was effective in obese patients. Coexistence of atrial fibrillation and obesity indicated lower SF-36 scores, but the improvement in quality of life was consistent across all body mass index categories.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.107.716712","type":"journal-article","created":{"date-parts":[[2008,5,13]],"date-time":"2008-05-13T01:09:55Z","timestamp":1210640995000},"page":"2583-2590","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":97,"title":["Catheter Ablation for Atrial Fibrillation in Patients With Obesity"],"prefix":"10.1161","volume":"117","author":[{"given":"Yong-Mei","family":"Cha","sequence":"first","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases (Y.-M.C., P.A.F., S.J.A., W.-K.S., T.M.M., R.F.R., P.A.B., A.J., K.H.M., B.J.G., S.C.H., D.L.P.) and Biostatistics (D.O.H., R.A.M.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Friedman","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases (Y.-M.C., P.A.F., S.J.A., W.-K.S., T.M.M., R.F.R., P.A.B., A.J., K.H.M., B.J.G., S.C.H., D.L.P.) and Biostatistics (D.O.H., R.A.M.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel J.","family":"Asirvatham","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases (Y.-M.C., P.A.F., S.J.A., W.-K.S., T.M.M., R.F.R., P.A.B., A.J., K.H.M., B.J.G., S.C.H., D.L.P.) and Biostatistics (D.O.H., R.A.M.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Win-Kuang","family":"Shen","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases (Y.-M.C., P.A.F., S.J.A., W.-K.S., T.M.M., R.F.R., P.A.B., A.J., K.H.M., B.J.G., S.C.H., D.L.P.) and Biostatistics (D.O.H., R.A.M.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Munger","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases (Y.-M.C., P.A.F., S.J.A., W.-K.S., T.M.M., R.F.R., P.A.B., A.J., K.H.M., B.J.G., S.C.H., D.L.P.) and Biostatistics (D.O.H., R.A.M.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Rea","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases (Y.-M.C., P.A.F., S.J.A., W.-K.S., T.M.M., R.F.R., P.A.B., A.J., K.H.M., B.J.G., S.C.H., D.L.P.) and Biostatistics (D.O.H., R.A.M.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Brady","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases (Y.-M.C., P.A.F., S.J.A., W.-K.S., T.M.M., R.F.R., P.A.B., A.J., K.H.M., B.J.G., S.C.H., D.L.P.) and Biostatistics (D.O.H., R.A.M.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshad","family":"Jahangir","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases (Y.-M.C., P.A.F., S.J.A., W.-K.S., T.M.M., R.F.R., P.A.B., A.J., K.H.M., B.J.G., S.C.H., D.L.P.) and Biostatistics (D.O.H., R.A.M.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi H.","family":"Monahan","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases (Y.-M.C., P.A.F., S.J.A., W.-K.S., T.M.M., R.F.R., P.A.B., A.J., K.H.M., B.J.G., S.C.H., D.L.P.) and Biostatistics (D.O.H., R.A.M.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David O.","family":"Hodge","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases (Y.-M.C., P.A.F., S.J.A., W.-K.S., T.M.M., R.F.R., P.A.B., A.J., K.H.M., B.J.G., S.C.H., D.L.P.) and Biostatistics (D.O.H., R.A.M.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan A.","family":"Meverden","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases (Y.-M.C., P.A.F., S.J.A., W.-K.S., T.M.M., R.F.R., P.A.B., A.J., K.H.M., B.J.G., S.C.H., D.L.P.) and Biostatistics (D.O.H., R.A.M.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard J.","family":"Gersh","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases (Y.-M.C., P.A.F., S.J.A., W.-K.S., T.M.M., R.F.R., P.A.B., A.J., K.H.M., B.J.G., S.C.H., D.L.P.) and Biostatistics (D.O.H., R.A.M.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Hammill","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases (Y.-M.C., P.A.F., S.J.A., W.-K.S., T.M.M., R.F.R., P.A.B., A.J., K.H.M., B.J.G., S.C.H., D.L.P.) and Biostatistics (D.O.H., R.A.M.), Mayo Clinic, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas L.","family":"Packer","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases (Y.-M.C., P.A.F., S.J.A., W.-K.S., T.M.M., R.F.R., P.A.B., A.J., K.H.M., B.J.G., S.C.H., D.L.P.) and Biostatistics (D.O.H., R.A.M.), Mayo Clinic, Rochester, 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