{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:48:16Z","timestamp":1790045296394,"version":"4.0.1"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2010,3,9]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Previous studies suggest that management of ambulatory hemodynamics may improve outcomes in chronic heart failure. We conducted a prospective, observational, first-in-human study of a physician-directed patient self-management system targeting left atrial pressure.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Forty patients with reduced or preserved left ventricular ejection fraction and a history of New York Heart Association class III or IV heart failure and acute decompensation were implanted with an investigational left atrial pressure monitor, and readings were acquired twice daily. For the first 3 months, patients and clinicians were blinded as to these readings, and treatment continued per usual clinical assessment. Thereafter, left atrial pressure and individualized therapy instructions guided by these pressures were disclosed to the patient. Event-free survival was determined over a median follow-up of 25 months (range 3 to 38 months). Survival without decompensation was 61% at 3 years, and events tended to be less frequent after the first 3 months (hazard ratio 0.16 [95% confidence interval 0.04 to 0.68],\n            <jats:italic>P<\/jats:italic>\n            =0.012). Mean daily left atrial pressure fell from 17.6 mm Hg (95% confidence interval 15.8 to 19.4 mm Hg) in the first 3 months to 14.8 mm Hg (95% confidence interval 13.0 to 16.6 mm Hg;\n            <jats:italic>P<\/jats:italic>\n            =0.003) during pressure-guided therapy. The frequency of elevated readings (&gt;25 mm Hg) was reduced by 67% (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). There were improvements in New York Heart Association class (\u22120.7\u00b10.8,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) and left ventricular ejection fraction (7\u00b110%,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). Doses of angiotensin-converting enzyme\/angiotensin-receptor blockers and \u03b2-blockers were uptitrated by 37% (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) and 40% (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001), respectively, whereas doses of loop diuretics fell by 27% (\n            <jats:italic>P<\/jats:italic>\n            =0.15).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Physician-directed patient self-management of left atrial pressure has the potential to improve hemodynamics, symptoms, and outcomes in advanced heart failure.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Clinical Trial Registration Information\u2014<\/jats:italic>\n            <\/jats:bold>\n            URL: http:\/\/www.clinicaltrials.gov. Unique identifier: NCT00547729.\n          <\/jats:p>","DOI":"10.1161\/circulationaha.108.800490","type":"journal-article","created":{"date-parts":[[2010,2,23]],"date-time":"2010-02-23T03:46:58Z","timestamp":1266896818000},"page":"1086-1095","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":276,"title":["Physician-Directed Patient Self-Management of Left Atrial Pressure in Advanced Chronic Heart Failure"],"prefix":"10.1161","volume":"121","author":[{"given":"Jay","family":"Ritzema","sequence":"first","affiliation":[{"name":"From the University of Otago (J.R., R.T., M.R., C.M.F.), Christchurch, New Zealand; Department of Cardiology (I.M., I.C.), Christchurch Hospital, Christchurch, New Zealand; Auckland City Hospital (R.D.), Auckland, New Zealand; The Alfred Hospital (H.K., A.W.), Melbourne, Australia; Oklahoma Cardiovascular Research Group (P.A.), Oklahoma City, Okla; Cedars-Sinai Medical Center (S.K., P.K.S., N.L.E., J.S.W.), Los Angeles, Calif; Scripps Clinic (J.T.H.), La Jolla, Calif; and The Ohio State University ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Troughton","sequence":"additional","affiliation":[{"name":"From the University of Otago (J.R., R.T., M.R., C.M.F.), Christchurch, New Zealand; Department of Cardiology (I.M., I.C.), Christchurch Hospital, Christchurch, New Zealand; Auckland City Hospital (R.D.), Auckland, New Zealand; The Alfred Hospital (H.K., A.W.), Melbourne, Australia; Oklahoma Cardiovascular Research Group (P.A.), Oklahoma City, Okla; Cedars-Sinai Medical Center (S.K., P.K.S., N.L.E., J.S.W.), Los Angeles, Calif; Scripps Clinic (J.T.H.), La Jolla, Calif; and The Ohio State University ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Melton","sequence":"additional","affiliation":[{"name":"From the University of Otago (J.R., R.T., M.R., C.M.F.), Christchurch, New Zealand; Department of Cardiology (I.M., I.C.), Christchurch Hospital, Christchurch, New Zealand; Auckland City Hospital (R.D.), Auckland, New Zealand; The Alfred Hospital (H.K., A.W.), Melbourne, Australia; Oklahoma Cardiovascular Research Group (P.A.), Oklahoma City, Okla; Cedars-Sinai Medical Center (S.K., P.K.S., N.L.E., J.S.W.), Los Angeles, Calif; Scripps Clinic (J.T.H.), La Jolla, Calif; and The Ohio State University ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Crozier","sequence":"additional","affiliation":[{"name":"From the University of Otago (J.R., R.T., M.R., C.M.F.), Christchurch, New Zealand; Department of Cardiology (I.M., I.C.), Christchurch Hospital, Christchurch, New Zealand; Auckland City Hospital (R.D.), Auckland, New Zealand; The Alfred Hospital (H.K., A.W.), Melbourne, Australia; Oklahoma Cardiovascular Research Group (P.A.), Oklahoma City, Okla; Cedars-Sinai Medical Center (S.K., P.K.S., N.L.E., J.S.W.), Los Angeles, Calif; Scripps Clinic (J.T.H.), La Jolla, Calif; and The Ohio State University ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Doughty","sequence":"additional","affiliation":[{"name":"From the University of Otago (J.R., R.T., M.R., C.M.F.), Christchurch, New Zealand; Department of Cardiology (I.M., I.C.), Christchurch Hospital, Christchurch, New Zealand; Auckland City Hospital (R.D.), Auckland, New Zealand; The Alfred Hospital (H.K., A.W.), Melbourne, Australia; Oklahoma Cardiovascular Research Group (P.A.), Oklahoma City, Okla; Cedars-Sinai Medical Center (S.K., P.K.S., N.L.E., J.S.W.), Los Angeles, Calif; Scripps Clinic (J.T.H.), La Jolla, Calif; and The Ohio State University ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Krum","sequence":"additional","affiliation":[{"name":"From the University of Otago (J.R., R.T., M.R., C.M.F.), Christchurch, New Zealand; Department of Cardiology (I.M., I.C.), Christchurch Hospital, Christchurch, New Zealand; Auckland City Hospital (R.D.), Auckland, New Zealand; The Alfred Hospital (H.K., A.W.), Melbourne, Australia; Oklahoma Cardiovascular Research Group (P.A.), Oklahoma City, Okla; Cedars-Sinai Medical Center (S.K., P.K.S., N.L.E., J.S.W.), Los Angeles, Calif; Scripps Clinic (J.T.H.), La Jolla, Calif; and The Ohio State University ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Walton","sequence":"additional","affiliation":[{"name":"From the University of Otago (J.R., R.T., M.R., C.M.F.), Christchurch, New Zealand; Department of Cardiology (I.M., I.C.), Christchurch Hospital, Christchurch, New Zealand; Auckland City Hospital (R.D.), Auckland, New Zealand; The Alfred Hospital (H.K., A.W.), Melbourne, Australia; Oklahoma Cardiovascular Research Group (P.A.), Oklahoma City, Okla; Cedars-Sinai Medical Center (S.K., P.K.S., N.L.E., J.S.W.), Los Angeles, Calif; Scripps Clinic (J.T.H.), La Jolla, Calif; and The Ohio State University ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Adamson","sequence":"additional","affiliation":[{"name":"From the University of Otago (J.R., R.T., M.R., C.M.F.), Christchurch, New Zealand; Department of Cardiology (I.M., I.C.), Christchurch Hospital, Christchurch, New Zealand; Auckland City Hospital (R.D.), Auckland, New Zealand; The Alfred Hospital (H.K., A.W.), Melbourne, Australia; Oklahoma Cardiovascular Research Group (P.A.), Oklahoma City, Okla; Cedars-Sinai Medical Center (S.K., P.K.S., N.L.E., J.S.W.), Los Angeles, Calif; Scripps Clinic (J.T.H.), La Jolla, Calif; and The Ohio State University ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saibal","family":"Kar","sequence":"additional","affiliation":[{"name":"From the University of Otago (J.R., R.T., M.R., C.M.F.), Christchurch, New Zealand; Department of Cardiology (I.M., I.C.), Christchurch Hospital, Christchurch, New Zealand; Auckland City Hospital (R.D.), Auckland, New Zealand; The Alfred Hospital (H.K., A.W.), Melbourne, Australia; Oklahoma Cardiovascular Research Group (P.A.), Oklahoma City, Okla; Cedars-Sinai Medical Center (S.K., P.K.S., N.L.E., J.S.W.), Los Angeles, Calif; Scripps Clinic (J.T.H.), La Jolla, Calif; and The Ohio State University ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prediman K.","family":"Shah","sequence":"additional","affiliation":[{"name":"From the University of Otago (J.R., R.T., M.R., C.M.F.), Christchurch, New Zealand; Department of Cardiology (I.M., I.C.), Christchurch Hospital, Christchurch, New Zealand; Auckland City Hospital (R.D.), Auckland, New Zealand; The Alfred Hospital (H.K., A.W.), Melbourne, Australia; Oklahoma Cardiovascular Research Group (P.A.), Oklahoma City, Okla; Cedars-Sinai Medical Center (S.K., P.K.S., N.L.E., J.S.W.), Los Angeles, Calif; Scripps Clinic (J.T.H.), La Jolla, Calif; and The Ohio State University ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Richards","sequence":"additional","affiliation":[{"name":"From the University of Otago (J.R., R.T., M.R., C.M.F.), Christchurch, New Zealand; Department of Cardiology (I.M., I.C.), Christchurch Hospital, Christchurch, New Zealand; Auckland City Hospital (R.D.), Auckland, New Zealand; The Alfred Hospital (H.K., A.W.), Melbourne, Australia; Oklahoma Cardiovascular Research Group (P.A.), Oklahoma City, Okla; Cedars-Sinai Medical Center (S.K., P.K.S., N.L.E., J.S.W.), Los Angeles, Calif; Scripps Clinic (J.T.H.), La Jolla, Calif; and The Ohio State University ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal L.","family":"Eigler","sequence":"additional","affiliation":[{"name":"From the University of Otago (J.R., R.T., M.R., C.M.F.), Christchurch, New Zealand; Department of Cardiology (I.M., I.C.), Christchurch Hospital, Christchurch, New Zealand; Auckland City Hospital (R.D.), Auckland, New Zealand; The Alfred Hospital (H.K., A.W.), Melbourne, Australia; Oklahoma Cardiovascular Research Group (P.A.), Oklahoma City, Okla; Cedars-Sinai Medical Center (S.K., P.K.S., N.L.E., J.S.W.), Los Angeles, Calif; Scripps Clinic (J.T.H.), La Jolla, Calif; and The Ohio State University ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Whiting","sequence":"additional","affiliation":[{"name":"From the University of Otago (J.R., R.T., M.R., C.M.F.), Christchurch, New Zealand; Department of Cardiology (I.M., I.C.), Christchurch Hospital, Christchurch, New Zealand; Auckland City Hospital (R.D.), Auckland, New Zealand; The Alfred Hospital (H.K., A.W.), Melbourne, Australia; Oklahoma Cardiovascular Research Group (P.A.), Oklahoma City, Okla; Cedars-Sinai Medical Center (S.K., P.K.S., N.L.E., J.S.W.), Los Angeles, Calif; Scripps Clinic (J.T.H.), La Jolla, Calif; and The Ohio State University ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrie J.","family":"Haas","sequence":"additional","affiliation":[{"name":"From the University of Otago (J.R., R.T., M.R., C.M.F.), Christchurch, New Zealand; Department of Cardiology (I.M., I.C.), Christchurch Hospital, Christchurch, New Zealand; Auckland City Hospital (R.D.), Auckland, New Zealand; The Alfred Hospital (H.K., A.W.), Melbourne, Australia; Oklahoma Cardiovascular Research Group (P.A.), Oklahoma City, Okla; Cedars-Sinai Medical Center (S.K., P.K.S., N.L.E., J.S.W.), Los Angeles, Calif; Scripps Clinic (J.T.H.), La Jolla, Calif; and The Ohio State University ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Thomas","family":"Heywood","sequence":"additional","affiliation":[{"name":"From the University of Otago (J.R., R.T., M.R., C.M.F.), Christchurch, New Zealand; Department of Cardiology (I.M., I.C.), Christchurch Hospital, Christchurch, New Zealand; Auckland City Hospital (R.D.), Auckland, New Zealand; The Alfred Hospital (H.K., A.W.), Melbourne, Australia; Oklahoma Cardiovascular Research Group (P.A.), Oklahoma City, Okla; Cedars-Sinai Medical Center (S.K., P.K.S., N.L.E., J.S.W.), Los Angeles, Calif; Scripps Clinic (J.T.H.), La Jolla, Calif; and The Ohio State University ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Frampton","sequence":"additional","affiliation":[{"name":"From the University of Otago (J.R., R.T., M.R., C.M.F.), Christchurch, New Zealand; Department of Cardiology (I.M., I.C.), Christchurch Hospital, Christchurch, New Zealand; Auckland City Hospital (R.D.), Auckland, New Zealand; The Alfred Hospital (H.K., A.W.), Melbourne, Australia; Oklahoma Cardiovascular Research Group (P.A.), Oklahoma City, Okla; Cedars-Sinai Medical Center (S.K., P.K.S., N.L.E., J.S.W.), Los Angeles, Calif; Scripps Clinic (J.T.H.), La Jolla, Calif; and The Ohio State University ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Abraham","sequence":"additional","affiliation":[{"name":"From the University of Otago (J.R., R.T., M.R., C.M.F.), Christchurch, New Zealand; Department of Cardiology (I.M., I.C.), Christchurch Hospital, Christchurch, New Zealand; Auckland City Hospital (R.D.), Auckland, New Zealand; The Alfred Hospital (H.K., A.W.), Melbourne, Australia; Oklahoma Cardiovascular Research Group (P.A.), Oklahoma City, Okla; Cedars-Sinai Medical Center (S.K., P.K.S., N.L.E., J.S.W.), Los Angeles, Calif; Scripps Clinic (J.T.H.), La Jolla, Calif; and The Ohio State University ..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.553370"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.02.004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.03.061"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.812172"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(02)00823-0"},{"key":"e_1_3_2_6_2","first-page":"963","volume":"291","year":"2004","unstructured":"Gheorghiade M, Gattis WA, O'Connor CM, Adams KF Jr, Elkayam U, Barbagelata A, Ghali JK, Benza RL, McGrew FA, Klapholz M, Ouyang J, Orlandi C. Effects of tolvaptan, a vasopressin antagonist, in patients hospitalized with worsening heart failure: a randomized controlled trial. JAMA. 2004; 291: 963\u20131971.","journal-title":"JAMA"},{"key":"e_1_3_2_7_2","first-page":"541","volume":"287","year":"2002","unstructured":"Cuffe MS, Califf RM, Adams KF Jr, Benza R, Bourge R, Colucci WS, Massie BM, O'Connor CM, Pina I, Quigg R, Silver MA, Gheorghiade M. Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial. JAMA. 2002; 287: 541\u20131547.","journal-title":"JAMA"},{"key":"e_1_3_2_8_2","first-page":"S21","volume":"4","year":"2003","unstructured":"Fonarow GC. The Acute Decompensated Heart Failure National Registry (ADHERE): opportunities to improve care of patients hospitalized with acute decompensated heart failure. 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