{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:29:07Z","timestamp":1789810147523,"version":"4.0.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2009,7,7]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>Background\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    The management of patients with asymptomatic severe aortic stenosis remains controversial. We sought to develop a continuous risk score for predicting the midterm development of symptoms or adverse events in this setting.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods and Results\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    We prospectively followed 107 patients with asymptomatic aortic stenosis (aged 72 years [63 to 77]; 35 women; aortic-jet velocity, 4.1 m\/s [3.5 to 4.4]) at a single center in France. Predefined end points for assessing outcome were the occurrence within 24 months of death or aortic valve replacement necessitated by symptoms or by a positive exercise test. Variables independently associated with outcome were used to build a score that was validated in an independent cohort of 107 patients from Belgium. Independent predictors of outcome were female sex, peak aortic-jet velocity, and B-type natriuretic peptide at baseline. Accordingly, the score could be calculated as follows: Score=[peak velocity (m\/s)\u00d72]+(natural logarithm of B-type natriuretic peptide\u00d71.5)+1.5 (if female sex). Event-free survival after 20 months was 80% for patients within the first score quartile compared with only 7% for the fourth quartile. Areas under the receiver operating characteristic curve for the score were 0.90 and 0.89 in the development and validation cohorts, respectively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusions\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    If further validation is achieved, this score may be useful to predict outcome in individual patients with asymptomatic aortic stenosis to select those who might benefit from early surgery.\n                  <\/jats:p>","DOI":"10.1161\/circulationaha.108.808857","type":"journal-article","created":{"date-parts":[[2009,6,22]],"date-time":"2009-06-22T21:56:12Z","timestamp":1245707772000},"page":"69-75","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":167,"title":["Risk Score for Predicting Outcome in Patients With Asymptomatic Aortic Stenosis"],"prefix":"10.1161","volume":"120","author":[{"given":"Jean-Luc","family":"Monin","sequence":"first","affiliation":[{"name":"From Assistance Publique-Ho\u0302pitaux de Paris, Department of Cardiology, Henri Mondor University Hospital, Cre\u0301teil, France (J.-L.M., P.L., E.W., P.G.); Department of Intensive Care Medicine, Institut Jacques Cartier, Massy, France (M.M.); and Sart Tilman University Hospital, Lie\u0300ge, Belgium, (P.L., L.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizio","family":"Lancellotti","sequence":"additional","affiliation":[{"name":"From Assistance Publique-Ho\u0302pitaux de Paris, Department of Cardiology, Henri Mondor University Hospital, Cre\u0301teil, France (J.-L.M., P.L., E.W., P.G.); Department of Intensive Care Medicine, Institut Jacques Cartier, Massy, France (M.M.); and Sart Tilman University Hospital, Lie\u0300ge, Belgium, (P.L., L.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehran","family":"Monchi","sequence":"additional","affiliation":[{"name":"From Assistance Publique-Ho\u0302pitaux de Paris, Department of Cardiology, Henri Mondor University Hospital, Cre\u0301teil, France (J.-L.M., P.L., E.W., P.G.); Department of Intensive Care Medicine, Institut Jacques Cartier, Massy, France (M.M.); and Sart Tilman University Hospital, Lie\u0300ge, Belgium, (P.L., L.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Lim","sequence":"additional","affiliation":[{"name":"From Assistance Publique-Ho\u0302pitaux de Paris, Department of Cardiology, Henri Mondor University Hospital, Cre\u0301teil, France (J.-L.M., P.L., E.W., P.G.); Department of Intensive Care Medicine, Institut Jacques Cartier, Massy, France (M.M.); and Sart Tilman University Hospital, Lie\u0300ge, Belgium, (P.L., L.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Weiss","sequence":"additional","affiliation":[{"name":"From Assistance Publique-Ho\u0302pitaux de Paris, Department of Cardiology, Henri Mondor University Hospital, Cre\u0301teil, France (J.-L.M., P.L., E.W., P.G.); Department of Intensive Care Medicine, Institut Jacques Cartier, Massy, France (M.M.); and Sart Tilman University Hospital, Lie\u0300ge, Belgium, (P.L., L.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Pie\u0301rard","sequence":"additional","affiliation":[{"name":"From Assistance Publique-Ho\u0302pitaux de Paris, Department of Cardiology, Henri Mondor University Hospital, Cre\u0301teil, France (J.-L.M., P.L., E.W., P.G.); Department of Intensive Care Medicine, Institut Jacques Cartier, Massy, France (M.M.); and Sart Tilman University Hospital, Lie\u0300ge, Belgium, (P.L., L.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Gue\u0301ret","sequence":"additional","affiliation":[{"name":"From Assistance Publique-Ho\u0302pitaux de Paris, Department of Cardiology, Henri Mondor University Hospital, Cre\u0301teil, France (J.-L.M., P.L., E.W., P.G.); Department of Intensive Care Medicine, Institut Jacques Cartier, Massy, France (M.M.); and Sart Tilman University Hospital, Lie\u0300ge, Belgium, (P.L., L.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.176857"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm095"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.104.495903"},{"key":"e_1_3_2_4_2","first-page":"357","volume":"13","year":"2004","unstructured":"Lund O, Erlandsen M, Dorup I, Emmertsen K, Flo C, Jensen FT. 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Philadelphia: WB Saunders; 1997: 405\u2013432."}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.108.808857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:56:35Z","timestamp":1715565395000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.108.808857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,7]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7,7]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.108.808857"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.108.808857","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1163463.625190","asserted-by":"object"}]},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,7]]},"assertion":[{"value":"2009-06-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}